EPIDEMIOLOGICAL STUDY ON RESPIRATORY ALLERGIC DISEASE AND BRONCHIAL HYPERREACTIVITY

呼吸道过敏性疾病和支气管高反应性的流行病学研究

• 批准号: 03670266
• 负责人: KUSAKA Yukinori
• 金额: $ 0.96万
• 依托单位: Fukui Medical School (1992-1993)Jichi Medical University (1991)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670266/
• 关键词: ALLERGY; ASTHMA; ALLERGEN; METAL; COBALT; ATOPY; SMOKING; LIFE STYLE; 職業性アレルギー; IgE; リンパ球; FcεR; CD23; アレルギ-; 呼吸器; 疫学; 気道過敏性; アトピ-

In recent times, allergic diseases, including asthma, have become much more prevalent in Japan as well as in developed countries. The present study was aimed at elucidating multifactorial relationships between allergic bronchial asthma and risk factors involvin atopic status, exposure levels of inhalant allergens, individual lifestyles, and biological markers at the molecular level. In the worker cohort exposed to cobalt, a respiratory sensitizer, bronchial asthma was highlighted as an endpoint and data on the indices relating the endpoint were collected. The following were suggested from the results of the sutdy : exposure to a sensitizer increases risk of asthma ; risk for asthma also increases with exposure level of the sensitizer in a dose-dependent manner ; atopy is strongly positively correlated with onset of asthma ; the risk of smoking and exposure to the sensitizer combine additively in leading to asthma. These suggestions are helpful for prevention of allergic diseases.

最近，在日本和发达国家，包括哮喘在内的过敏性疾病已经变得更加普遍。本研究旨在阐明过敏性支气管哮喘与危险因素的多因素关系，涉及特征状态，吸入过敏原的暴露水平，个体生活方式和分子水平的生物标志物。在暴露于钴的工人队列中，呼吸敏化剂，将支气管哮喘作为终点强调，并收集了有关端点指数的数据。从Sutdy的结果中提出了以下内容：暴露于敏化剂会增加哮喘的风险；哮喘的风险也随着剂量依赖的方式随着敏化剂的暴露水平而增加。与哮喘的发作密切相关。吸烟和暴露于敏化剂的风险可加上哮喘。这些建议有助于预防过敏性疾病。

项目成果

Hagihara,A: "Health risk appraisal(HRA)and its educational effect on bank employees." Ind.Health.30. 61-64 (1992)

Hagihara，A：“健康风险评估（HRA）及其对银行员工的教育作用。”

Kumagai,S: "Autocorrelation of Short-Term and Daily Average Exposure Levels in Workplaces." Am.Ind.Hyg.Assoc.J.54. 341-350 (1993)

Kumagai,S：“工作场所短期和每日平均暴露水平的自相关。”

日下幸則: "職業性金属アレルギーを“保健予防する"" 労働の科学. 48. 13-16 (1993)

Yukinori Kusaka：“职业性金属过敏的健康预防”。 劳动科学 48. 13-16 (1993)。

日下 幸則 他.: "ライフスタイルはナチュラルキラ-細胞活性を変化させるか?" 日本衛生学雑誌. 46. 1035-1042 (1991)

Yukinori Kusaka 等人：“生活方式会改变自然杀伤细胞活性吗？”日本卫生杂志 46. 1035-1042 (1991)

日下 幸則: "有害物質暴露者の免疫学的特性 ーコバルト・ニッケルー" 公衆衛生. 56. 167-170 (1992)

Yukinori Kusaka：“接触有毒物质 - 钴镍 - 的人的免疫学特征 -”公共卫生 56. 167-170 (1992)。