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Preliminary study of monochromatic X-ray CT with synchrotron radiation

同步辐射单色X射线CT的初步研究

基本信息

批准号：
03670538
负责人：
TAKEDA Tohoru
金额：
$ 1.34万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670538/
关键词：
synchrotron radiation computed tomography monochromatic X-ray biomedical diagnosis high resolution functional analysis synchrotoron radiation computed tomography biomedical diagnosis cerebral blood flow nuclear medicine functional an

项目摘要

From 1990, a biomedical SR-CT to detect tracer material up to a few mug iodine/ml is being developed for functional evaluations of regional blood flow and metabolism of the organs corresponding to their anatomical structures. The feasibility test of our SR-CT system is performed on phantom and rats.[Methods and material] SR-CT system consists of a rotating X-ray shutter, a silicon (111) channel-cut monochromator, a sample rotating system, X-ray slits and a detector system. Energy of monochromatic X-rays is set at 33.28 keV.Exposure time of each projection is set at 25 msec. The number of projection is 90. Experiment beam line is BLNE 5A of Tristan Accumulation Ring in Tsukuba. Imaging plate(IP) is used as the X-ray detector. The IP data is read by laser beam and digitized by 10 bit analog-to-digital converter (BAS-2000). The spot size of laser is 100 mum^2 with a 10 bit depth. CT image is reconstructed by the post-processing computer(HP 9000). Objects are small rod and brain phantom filled with an iodine, and rats.[Results] The image of above iodine K-edge shows the hole and ditch of phantom filled with iodine clearly. The 44.8 mum/ml iodine can be detected faintly. This concentration corresponds well to the theoretical value (59.7 mug/ml iodine). But this detectable dose of iodine is about 10 times larger than that of our purpose (5 mug/ml iodine). Main reason is poor dynamic range of laser reading system of IP.So to improve the system for detecting very low contrast agent, the sensor with wide dynamic range(50000) is needed.CT image of rat skull with 100 mum spatial resolution showed fine structures of nose, mandibular bone and skull. Final goal of this SR-CT is to detect 5 mug/ml iodine and to obtain less than 5 mm spatial resolution of the brain image like a PET study.

从 1990 年开始，人们正在开发一种生物医学 SR-CT，可检测高达几杯碘/毫升的示踪物质，用于对与其解剖结构相对应的器官的局部血流和代谢进行功能评估。我们的SR-CT系统在体模和大鼠上进行了可行性测试。 [方法和材料] SR-CT系统由旋转X射线快门、硅（111）通道切割单色仪、样品旋转系统、X射线狭缝和探测器系统组成。单色X射线的能量设置为33.28keV。每次投影的曝光时间设置为25毫秒。投影数量为90。实验光束线为筑波特里斯坦聚能环BLNE 5A。使用成像板（IP）作为X射线探测器。 IP数据通过激光束读取并通过10位模数转换器（BAS-2000）进行数字化。激光光斑尺寸为100μm^2，深度为10位。 CT图像由后处理计算机(HP 9000)重建。对象为小棒、充满碘的脑模体、大鼠。[结果]上方碘K边缘图像清晰地显示了充满碘的模体的孔洞和沟渠。微弱地检测到44.8μm/ml的碘。该浓度与理论值（59.7 微克/毫升碘）相符。但这个可检测的碘剂量大约比我们的目的（5 微克/毫升碘）大 10 倍。主要原因是IP激光读取系统的动态范围较差。因此，为了改进检测极低造影剂的系统，需要宽动态范围（50000）的传感器。空间分辨率为100μm的大鼠颅骨CT图像显示了鼻子、下颌骨和颅骨的精细结构。该 SR-CT 的最终目标是检测 5 微克/毫升的碘，并像 PET 研究一样获得小于 5 毫米的大脑图像空间分辨率。