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Development of fluorescent x-ray CT with synchrotron radiation

同步辐射荧光X射线CT的发展

基本信息

批准号：
10557084
负责人：
TAKEDA Tohoru
金额：
$ 8.7万
依托单位：
Institute of Clinical Medicine, University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

Fluorescent x-ray technique is usually used to evaluate very low contents of specific elements in the order of picograms, however the measurement must be performed in the surface of object. Then for biological sample, the specimen is required to be cut into thin slices and scanned with a beam perpendicular to its surface. The fluorescent x-ray computed tomography (FXCT), which can reveal the distribution of inner element of object and do not require the specific preparation, have being developed. Especially by positioning the x-ray detector at 90゜ to the beam, the linear polarization of synchrotron x-rays (SR) helps to significantly reduce the Compton scattering overlapping the KィイD2αィエD2 line and thus improving the minimal detectability of elements. Using a detector with high efficiency and high count-rate capability and highly precise x-ray collimator system, we implemented FXCT with high spatial resolution in the order of tens of micrometers.FXCT was applied to depict the cross sectional distribution of iodine in the thyroid gland, in vitro, at the spatial resolution of 0.1 mm x 0.1 mm with 0.1-mm slice thickness or of 0.025 mm x 0.025 mm with 0.025 mm slice thickness. FXCT with SR could clearly visualize the 0.005 mg/ml iodine solution in the 10-mm diameter 3-hole phantom at 0.1 x 0.1 mmィイD12ィエD1 spatial resolution with 0.1 mm slice thickness. Observation of the 0.005 mg/ml iodine solution indicated that the excited iodine content in the measured voxel is about 5 pg (0.005 mg/ml x 1.0 x 10ィイD1-6ィエD1 ml). In the thyroid cancer, FXCT revealed that a part of cancer had high content of iodine, whereas another part had low content of iodine. It varied wide ranges from 0.09 mg/g to 0.005mg/g.FXCT can obtain the image of specific elements by selecting the KィイD2αィエD2 fluorescent x-ray line, so many other elements such as zinc and cupper for enzyme function of tumor, and platinum for the cancer therapy will be imaged quantitatively.

荧光X射线技术通常用来评估皮克级的极低含量的特定元素，但测量必须在物体的表面进行。然后对于生物样品，需要将样品切割成薄片，并用垂直于其表面的光束进行扫描。荧光X射线计算机层析成像(FXCT)是一种不需要特殊准备，能显示物体内部元素分布的成像技术。特别是通过将X射线探测器定位在与光束90゜的位置，同步加速器X射线(SR)的线偏振有助于显著减少与KィイD2αィエD2线重叠的康普顿散射，从而提高元素的最小可探测性。使用高效率、高计数能力的探测器和高精度的X射线准直仪系统，实现了数十微米量级的高空间分辨率的FXCT，分别以0.1mmx0.1 mm和0.025 mm x0.025 mm的空间分辨率和0.025 mm的层厚在体外描绘了碘在甲状腺中的横截面分布。0.005 mg/ml3孔体模，空间分辨率为0.1x0.1 mm，ィイD12，ィエd1，层厚0.1 mm。对0.005 mg/ml碘溶液的观察表明，被测体素中的激发态碘含量约为5pg(0.005 mg/mlx1.0x10ィイd1-6ィエd1ml)。在甲状腺癌中，FXCT显示部分癌组织碘含量较高，而另一部分癌组织碘含量较低。FXCT可以通过选择KィイD2αィエD2荧光x线获得特定元素的图像，从而对肿瘤酶功能的锌、铜以及用于癌症治疗的铂等其他元素进行定量成像。