Development of high-speed fluorescent X-ray CT system

高速荧光X射线CT系统的研制

• 批准号: 17390326
• 负责人: TAKEDA Tohoru
• 金额: $ 9.92万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390326/
• 关键词: Fluorescent X-ray; Computed Tomography; Specific element; In vivo imaging; Functional imaging; Absorption-contrast X-ray CT; Morphological imaging; Fusion imaging; 形態画像

In recent biomedical research, the innovation of the new imaging techniques with high-contrast and high-spatial resolution is required for molecular imaging. Fluorescent x-ray technique used in the planar mode is one of the most sensitive methods for detecting trace elements of large atomic numbers in the order of picogram. However, the specimen must be cut into thin slices and be scanned with a beam perpendicular to its surface. Fluorescent x-ray CT (FXCT) method described here combines the sensitivity of fluorescence x-ray technique and the cross-sectional description of CT. Since FXCT can detect small amount of heavy atomic number element as iodine, our group has been developing FXCT system for molecular imaging. Here, we describe the development of high-speed FXCT system for in-vivo FXCT imaging.FXCT system consists of a silicon (220) double crystal monochromator, an x-ray slit system, a scanning table, highly purity germanium (HP-Ge) detector, and pin-diode detectors. To perform h … More igh-speed data detection, 3 channel-type HP-Ge detector was manufactured. The experiment was carried out at the bending-magnet beam line of the Tristan accumulation ring in Tsukuba, Japan. Monochromatic x-ray energy was set 37keV. The incident monochromatic x-ray was collimated into a pencil beam of 0.5 x 0.5mm^2 for the live objects, and less than 0.5 x 0.2 mm^2 for the phantom and pathological specimens, respectively. The data acquisition time was set 5 sec for each scanning step.In the fundamental phantom experiment, energy resolution of each channel was about 290-310 eV at the energy of 28keV. Using sheet beam exposure for phantom, energy spectrum of iodine was clearly separated from Compton scattering X-ray. 1-127 labeled IMP inside the brain of a live mouse was clearly imaged by FXCT at a 0.5 mm spatial resolution and a 0.5 mm slice thickness. Transmission x-ray CT that demonstrate geometrical structure of skull (skull bone, and surrounding soft tissue), can be simultaneously obtained with FXCT data. Then, the anatomical position corresponding functional changes can be understood easily. Now, this FXCT system is not sufficient to perform high speed FXCT imaging because high photon flux from object caused the significantly increased dead-time, and overflowed the electronics (ADC) of detector system. Less

在最近的生物医学研究中，分子成像需要创新高对比度和高空间分辨率的新成像技术。平面模式下的荧光X射线技术是探测皮格级大原子序数痕量元素最灵敏的方法之一。然而，样品必须被切割成薄片，并用垂直于其表面的光束进行扫描。本文介绍的荧光X射线CT(FXCT)方法结合了荧光X射线技术的敏感性和CT的横断面描述。由于FXCT可以探测到碘等少量重原子序数元素，我们小组一直在开发用于分子成像的FXCT系统。在此，我们描述了用于活体FXCT成像的高速FXCT系统的发展。FXCT系统由硅(220)双晶单色仪、X射线狭缝系统、扫描台、高纯锗(HP-Ge)探测器和PIN二极管探测器组成。要执行h…研制了更高速的数据检测、三通道型HP-GE探测器。这项实验是在日本筑波的特里斯坦聚集环的弯曲磁束线上进行的。单色X射线能量设置为37keV。将入射的单色X射线准直成铅笔光束，活体物体为0.5×0.5 mm^2，体模和病理标本分别小于0.5×0.2 mm^2。在基本体模实验中，在28keV能量下，每个通道的能量分辨率约为290-310 eV。通过对体模进行片束曝光，碘的能谱与康普顿散射X射线能谱明显分离。用FXCT以0.5 mm的空间分辨率和0.5 mm的层厚对活体小鼠脑内1-127标记的IMP进行了清晰的成像。透射式X光CT可以与FXCT数据同时获得显示颅骨(颅骨及其周围软组织)几何结构的CT。这样，就可以很容易地了解与功能变化相对应的解剖位置。目前，这种FXCT系统不足以进行高速FXCT成像，因为来自物体的高光子通量导致死区时间显著增加，并且溢出了探测器系统的电子(ADC)。较少

项目成果

Phase-contrast and fluorescent X-ray imaging for biomedical researches

• DOI: 10.1016/j.nima.2005.03.063
• 发表时间: 2005-08
• 期刊: Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment
• 影响因子: 1.4
• 作者: T. Takeda

Fusion imaging of fluorescent and phase-contrast x-ray computed tomography using synchrotron radiation in medical biology

• DOI: 10.1117/12.680133
• 发表时间: 2006-08
• 期刊: Nature
• 影响因子: 64.8
• 作者: Jin Wu;T. Takeda;T. Lwin;N. Sunaguchi;T. Fukami;T. Yuasa;M. Minami;T. Akatsuka

Progress in biomedical application of phase-contrast x-ray imaging and flurescent x-ray CT.

相衬X射线成像和荧光X射线CT在生物医学应用的进展。

• 发表时间: 2006
• 期刊: Proc. SPIE 6318
• 作者: Wu J;Takeda T;Tohoru Takeda
• 通讯作者: Tohoru Takeda

In-vivo imaging of tracer element with fluorescent X-ray computed tomography.

使用荧光 X 射线计算机断层扫描对示踪元素进行体内成像。

• 发表时间: 2005
• 期刊: Proc. 6^<th> Asian-Pacific Conference on Medical and Biological Engineering PA-3-33
• 作者: Wu J;Takeda T;Tohoru Takeda;Tohoru Takeda;Tohoru Takeda;Tohoru Takeda;Tohoru Takeda
• 通讯作者: Tohoru Takeda

Preliminary quantitative analysis of myocardial fatty acid metabolism from fluorescent X・ray CT image

从荧光X·射线CT图像初步定量分析心肌脂肪酸代谢

• 发表时间: 2007
• 期刊: J. Synchrotron Rad Vol. 14
• 作者: Thet Thet Lwin;T. Takeda;J. Wu;N. Sunaguchi;T. Murakami;S. Mouri;S. Nasukawa;Q. Hu0;T. Yuasa;K. Hyodo;T. Akatsuka
• 通讯作者: T. Akatsuka