Multi-energy autoradiography with solid state detector.

带固态探测器的多能量放射自显影。

• 批准号: 08671004
• 负责人: TAKEDA Tohoru
• 金额: $ 1.6万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671004/
• 关键词: Autoradiogram; solid state detector; multi energy spectrum; imaging; biologcal object; Autoradiography; Quantitative analysis; Germanium detector; SSD; Radionuclide

Now various types of new radionuclide agents, which can reveal the patho-physiological informations of organ, has been developing. For example in the analysis of myocardial tissue, we can assess the various myocardial function ; regional myocardial perfusion using Tl-201 or Tc-99m TF,fatty metabolism using I-123 BMIPP,sympathetic nerve function using I-123 MIBG,and myocardial infarction using Tc-99m PYP.To understand the patho-physiological conditions in various myocardial diseases as ischemia, cardiomyopathy and heart failure, regional myocardial function mentioned above must be assessed. However, imaging of each agents must be performed separately because the present available detector such as x-ray film or imaging plate cannot separate energy spectrum.Highly purified germanium solid state (HPGe) detector can detect the energy spectrum of x-ray and gamma ray clearly with highly sensitivity. Multi-energy autoradiographic system was develope in this experiment. This system consisted of (HPGe) detector, collimator, scan table and computer system. Inthe phantom experiment, Tc-99m, I-123 and Tl-201 could clearly imaged. In the normal myocardium perfused by I-125 BMIPP and Tl-201, each agents could be separated clearly. The spatial resolution of this preliminary system was poor comparing to the imaging plate, but the different radionuclide agent colud be clearly separated simultaneously.Multi-energy autoradiography with solid state detector was thought to have great possibility to analyze patho-physiological condition at same time.

近年来，各种新型的放射性核素不断发展，能够揭示器官的病理生理信息。例如在心肌组织分析中，我们可以评估各种心肌功能;用Tl-201或Tc-99 m TF进行局部心肌灌注，用I-123 BMIPP进行脂肪代谢，用I-123 MIBG进行交感神经功能检查，用Tc-99 m PYP进行心肌梗死检查。必须评估上述局部心肌功能。但是，现有的探测器如X射线胶片或成像板不能分离能谱，必须分别对每种物质进行成像，高纯锗（HPGe）探测器可以清晰、高灵敏度地探测X射线和γ射线的能谱。本实验研制了多能放射自显影系统。该系统由HPGe探测器、准直器、扫描台和计算机系统组成。在体模实验中，Tc-99 m、I-123和Tl-201均能清晰成像。在I-125 BMIPP和Tl-201灌注的正常心肌中，各药物可清楚分离。与成像板相比，该系统的空间分辨率较差，但能同时清晰地分离不同核素，为多能固体探测器放射自显影同时分析病理生理状态提供了可能。

项目成果

星野充紀: "多核種同時計測オートラジオグラフィ" Medical Imaging Technology. 15. 455-456 (1997)

Mitsunori Hoshino：“同时多核素测量放射自显影”医学成像技术 15. 455-456 (1997)。