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Multi-energy autoradiography with solid state detector.

带固态探测器的多能量放射自显影。

基本信息

批准号：
08671004
负责人：
TAKEDA Tohoru
金额：
$ 1.6万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671004/
关键词：
Autoradiogram solid state detector multi energy spectrum imaging biologcal object Autoradiography Quantitative analysis Germanium detector SSD Radionuclide

项目摘要

Now various types of new radionuclide agents, which can reveal the patho-physiological informations of organ, has been developing. For example in the analysis of myocardial tissue, we can assess the various myocardial function ; regional myocardial perfusion using Tl-201 or Tc-99m TF,fatty metabolism using I-123 BMIPP,sympathetic nerve function using I-123 MIBG,and myocardial infarction using Tc-99m PYP.To understand the patho-physiological conditions in various myocardial diseases as ischemia, cardiomyopathy and heart failure, regional myocardial function mentioned above must be assessed. However, imaging of each agents must be performed separately because the present available detector such as x-ray film or imaging plate cannot separate energy spectrum.Highly purified germanium solid state (HPGe) detector can detect the energy spectrum of x-ray and gamma ray clearly with highly sensitivity. Multi-energy autoradiographic system was develope in this experiment. This system consisted of (HPGe) detector, collimator, scan table and computer system. Inthe phantom experiment, Tc-99m, I-123 and Tl-201 could clearly imaged. In the normal myocardium perfused by I-125 BMIPP and Tl-201, each agents could be separated clearly. The spatial resolution of this preliminary system was poor comparing to the imaging plate, but the different radionuclide agent colud be clearly separated simultaneously.Multi-energy autoradiography with solid state detector was thought to have great possibility to analyze patho-physiological condition at same time.

目前，各种能够揭示器官病理生理信息的新型放射性核素剂不断涌现。例如，在分析心肌组织时，我们可以评估各种心肌功能：使用TL-201或Tc-99m TF的局部心肌灌注，使用I-123 BMIPP的脂肪代谢，使用I-123 MIBG的交感神经功能，以及使用Tc-99m PYP的心肌梗死。要了解各种心肌疾病的病理生理状况，如缺血、心肌病和心力衰竭，必须评估上述局部心肌功能。然而，现有的X射线胶片或显像板等探测器不能分离能谱，因此必须单独进行各剂型的成像，高纯度的锗固态探测器可以高灵敏度、清晰地探测X射线和伽马射线的能谱。本实验研制了多能量放射自显影系统。该系统由(HPGe)探测器、准直器、扫描台和计算机系统组成。在体模实验中，~(99m)Tc、~(123)I和~(201)Tl均能清晰显示。在I-125BMIPP和TL-201灌流的正常心肌中，两种药物均能清晰地分离。该初步系统的空间分辨率不如显像板，但可以同时清晰地分离不同的放射性核素剂。固体探测器多能放射自显影被认为是同时分析病理生理状况的很大可能性。