Development of fluorescent x-ray detection technique in FXCT
Development of fluorescent x-ray detection technique in FXCT
批准号:
13470178
负责人:
TAKEDA Tohoru
金额:
$10.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002
中文摘要
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英文摘要
Fluorescent x-ray technique is used to evaluate very low contents of specific elements in the order of picograms, however the measurement must be performed in the surfade of object. Then for in biological sample, the specimen is required to be cut into thin slices and scanned with a beam perpendicular to its surface. Fluorescent x-ray computed tomography (FXCT) have being developed to reveal the distribution of specific element in living state. By positioning the x-ray detector at 90° to the beam, the linear polarization of synchrotron x-rays helps to significantly reduce the Compton scattering overlapping the K_α line of specific elements. However, Compton scattering has increased markedly in large object, and highly purified germanium detector cannot measure the huge amounts of photon. To improve this problem, three experiments such as filter method, parallel collimator method and Laue-mirror method, were done to examine the reduction of Compton scattering from object.Filter method, which is firstly thought most easy and highly effective method to reduce Compton scattering, is not useful because secondary fluorescent x-ray was generated by filter itself and this fluorescent x-ray overlaps on the iodine K_α line. Intense parallel collimator method, which reduces the efficacy of fluorescent x-ray detection, is most effective to reduce Compton scattering and to detect small amounts of fluorescent x-ray. Most ideal Laue-mirror method is difficult to set up the mirror system, so further improvement of x-ray mirror and its dedicate control is needed.For in vivo FXCT imaging, collimator or Laue-mirror method appear to be an useful technique to reduce the huge amounts of Compton scattering from large object.
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Tohoru Takeda: "Iodine imaging in thyroid by fluorescent x-ray CT with 0.05mm spatial resolution"Nuclear Instruments and Method in Physics Research. A467-468. 1318-1321 (2001)
Tohoru Takeda:“通过荧光 X 射线 CT 进行甲状腺碘成像,空间分辨率为 0.05 毫米”物理研究中的核仪器和方法。
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通讯作者:
D.V.Rao, Takeda T, Itai Y, Akatsuka T, Cesareo R, Brunetti A, Gigante GE: "Doppler broadening and its contribution to compton energy-absorption cross sections : An analysis of the compton component in terms of mass-energy absorption coefficient"J.Phys.Che
D.V.Rao、Takeda T、Itai Y、Akatsuka T、Cesareo R、Brunetti A、Gigante GE:“多普勒展宽及其对康普顿能量吸收截面的贡献:根据质能吸收系数对康普顿分量进行分析”
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Tsutomu Zeniya: "Integrated image presentation of transmission and fluorescent x-ray CT using synchrotron radiation"Nuclear Instruments and Method in Physics Research. A467-468. 1326-1328 (2001)
Tsutomu Zeniya:“使用同步加速器辐射的透射和荧光 X 射线 CT 的集成图像呈现”物理研究中的核仪器和方法。
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Tohoru Takeda: "Progress in Pathology Volume 5"Greenwich Medical Media Ltd. UK. 194 (2001)
Tohoru Takeda:“病理学进展第 5 卷”英国格林威治医学媒体有限公司。
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Takeda T, Yu Q, Yashiro T, Zeniya T, Wu J, Hasegawa Y, Thet-Thet-Lwin, Hyodo K, Yuasa T, Dilmanian FA, Akatsuka T, Itai Y: "Iodine imaging in thyroid by fluorescent x-ray CT with 0.05mm spatial resolution"Nuclear Instruments and Method in Physics Research
Takeda T、Yu Q、Yashiro T、Zeniya T、Wu J、Hasekawa Y、Thet-Thet-Lwin、Hyodo K、Yuasa T、Dilmanian FA、Akatsuka T、Itai Y:“通过荧光 X 射线 CT 进行甲状腺碘成像
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共 24 条
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Biological observation with fluorescent X-ray CT
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负责人:TAKEDA Tohoru
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依托单位:
海外基金