Relation between psychiatric function and immune function ; psychoneuroimmunological study on response to stress and psychiatric illness

精神功能与免疫功能的关系；

• 批准号: 03670562
• 负责人: KOMORI Teruhisa
• 金额: $ 1.34万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670562/
• 关键词: Psychiatric function; Immune function; Stress; Neuroendocrine function; Depression; Antidepressants; Thyroid hormone; Olfactory bulb; 甲状腺; 神経免疫調節; 嗅球摘除; イミプラミン; 視床下部下垂体ー甲状腺系; 精神神経免疫学; プラック形成細胞; リンパ球サブセット; リンパ球機能

In 1991, we studied the effects of stress on immune function and the results indicated the effects of stress on immune function depend on the kind and duration of stress. Using restraint stress at 16 hours/day, 1-day restraint enhanced, whereas 3-day restraint suppressed immune function. Olfactory bulbectomy in mice, which are consedered as a depression model caused an inhibition of immune function and further suppression in response to 1-day restraint.In 1992, we studied the effects of antidepressants on immune function. the administration of imipramine at 5mg/kg/day for 3 days suppressed immune function in normal mice, whereas ded not exert any effect on olfactory bulbectomized mice. The administration of imipramine for 10 days suppressed immune function in normal mice, whereas restored immune function in olfactory bulbectomized mice. Effects of antidepressents on immune function may depend on neuronal state. Among various interactions between neuroendocrine and immune system, we focused on the effects of thyroid function on immune function. because thyroid function is often relevant to depressive state. Results indecated that thyroid hormone may be importantin maintaining and stabilizing immune function in spite of immunosuppressive effect itself.In the end of 1992 and 1993, we studied immune function in relation to neuroendocrine function, treatments and clinical course in depressive patients We get officially the informed consent from all patients. Although abnormal values in various immunologicalindices including CD4/8 and NK activity were found, any correlation to neuroendocrine function, the subytpes of depression or age was not found. Appropriate treatments, hoewver, improved clinical condition with normalization of neuroendocrine and immune indices. We are further studying the relation between the immune function and psychiatric illness.

In 1991, we studied the effects of stress on immune function and the results indicated the effects of stress on immune function depend on the kind and duration of stress. Using restraint stress at 16 hours/day, 1-day restraint enhanced, whereas 3-day restraint suppressed immune function. Olfactory bulbectomy in mice, which are consedered as a depression model caused an inhibition of immune function and further suppression in response to 1-day restraint.In 1992, we studied the effects of antidepressants on immune function. the administration of imipramine at 5mg/kg/day for 3 days suppressed immune function in normal mice, whereas ded not exert any effect on olfactory bulbectomized mice. The administration of imipramine for 10 days suppressed immune function in normal mice, whereas restored immune function in olfactory bulbectomized mice. Effects of antidepressents on immune function may depend on neuronal state. Among various interactions between neuroendocrine and immune system, we focused on the effects of thyroid function on immune function. because thyroid function is often relevant to depressive state. Results indecated that thyroid hormone may be importantin maintaining and stabilizing immune function in spite of immunosuppressive effect itself.In the end of 1992 and 1993, we studied immune function in relation to neuroendocrine function, treatments and clinical course in depressive patients We get officially the informed consent from all patients. Although abnormal values in various immunologicalindices including CD4/8 and NK activity were found, any correlation to neuroendocrine function, the subytpes of depression or age was not found. Appropriate treatments, hoewver, improved clinical condition with normalization of neuroendocrine and immune indices. We are further studying the relation between the immune function and psychiatric illness.

项目成果

小森照久: "うつ病,および抗うつ薬の作用の精神神経免疫学的検討" 精神薬療基金研究年報. 23. 169-174 (1992)

Teruhisa Komori：“抑郁症的心理神经免疫学研究和抗抑郁药的作用”精神药理学治疗基金会年度报告 23. 169-174 (1992)。

小森 照久: "視床下部下垂体ー甲状腺系をめぐる精神神経免疫学的検討" 精神薬療基金研究年報. 24. (1993)

Teruhisa Komori：“下丘脑-垂体-甲状腺系统的心理神经免疫学研究”精神药理学治疗基金会研究年度报告24。（1993）

小森 照久: "うつ病,および抗うつ薬の作用の精神神経免疫学的検討" 精神薬療基金研究年報. 23. (1992)

Teruhisa Komori：“抑郁症的心理神经免疫学研究和抗抑郁药的作用”精神药理学治疗基金会年度报告23。（1992）。

小森照久: "視床下部下垂体一甲状腺系をめぐる精神神経免疫学的検討" 精神薬療基金研究年報. 24. 50-54 (1993)

Teruhisa Komori：“下丘脑-垂体-单甲状腺系统的心理神经免疫学研究”精神药理学治疗基金会年度报告 24. 50-54 (1993)。

Teruhisa Komori, Ryoichi Fujiwara, Masahiro Tanida and Junichi Nomura18GB04 : A new treatment for depression by fragrances : psychoneuroimmunological evaluation: Japanise Journal of Psychiatry and Neurology. 47. 717 (1993)

Teruhisa Komori、Ryoichi Fujiwara、Masahiro Tanida 和 Junichi Nomura18GB04：香水治疗抑郁症的新疗法：心理神经免疫学评估：日本精神病学和神经病学杂志。