Study of vasoconstrictire protein in renal artery

肾动脉缩血管蛋白的研究

• 批准号: 03670744
• 负责人: NAKADA Teruhiro
• 金额: $ 1.41万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670744/
• 关键词: SHR, SHRSP; non-collagen protein; collagen; renovascular hypertension; phenoxybenzamine; hypertension; norepinephrine; neural factor; pnenoxybenzamine; 非コラ-ジェン蛋白質; コラ-ジェン; エラスチン; 高血圧症; 腎動脈

Synthesis of vascular protein was investigated in renal arteries of stroke-prone and-resistant spontaneously hypertensive rats (SHR, SHRSP). The effect of POB and surgical or pharmacological denervation of the root of the renal and/or mesenteric arteries prevented the development of hypertension of these animals. Incorporation of tritiated proline into the vessels described above were also decreased following the antihypertensive treatments. Positive correlations of ^3H-proline incorporation into the renal or mesenteric artery and systolic blood pressure were remarkably noted.However, in chronic hypertensive stages, these relationship were not observed.Based on these findings, vasoconstractive protein, especially non-collagenous protein and collagen appear to possess a vasoconstractive capability. These connective tissue protein was probably mediated neural factors.In clinical patients, contents of non-collagenous protein and collagen revealed to be high in hypertensive patients.

研究了卒中易发和抵抗型自发性高血压大鼠肾动脉血管蛋白的合成。POB和肾和/或肠系膜动脉根的手术或药物去神经支配的作用阻止了这些动物高血压的发展。上述血管中氚化脯氨酸的掺入在抗高血压治疗后也有所减少。^ 3h -脯氨酸掺入肾动脉或肠系膜动脉与收缩压显著正相关。然而，在慢性高血压阶段，没有观察到这些关系。基于这些发现，血管收缩蛋白，特别是非胶原蛋白和胶原蛋白似乎具有血管收缩能力。这些结缔组织蛋白可能是介导的神经因子。在临床患者中，高血压患者的非胶原蛋白和胶原蛋白含量均较高。

项目成果

Nakada,T. et al.: "Adrenal Surgery (in Japanese)" Atlas of Endocrine Surgery. (1992)

中田，T.

Watanabe,H., Nakada,T.et al.:"Crossed ectopia of left vas deferens, leaving ipsilateral seminal vesicle in normal position." J.Urol.148. 886-888 (1992)

Watanabe,H., Nakada,T.et al.：“跨越左侧输精管异位，使同侧精囊处于正常位置。”

金子 尚嗣、中田 瑛浩: "ラットの2腎性腎血管性高血圧症の急性期における交感神経および血管蛋白質に関する研究" 腎移植血管外科. 3. 154-158 (1991)

Naotsu Kaneko、Eihiro Nakata：“大鼠双肾肾血管性高血压急性期交感神经和血管蛋白的研究”《肾移植和血管外科》，3. 154-158 (1991)。

Watanabe,M.,Nakada,T. et al.: "Crossed ectopia of left vas deferens,leaving ipsilateral seminal vesicle in normal position." J.Urol.148. 886-888 (1992)

渡边，M.，中田，T.

中田 瑛浩: "内分秘外科・標準手術アトラス" インターメルク社, 252 (1991)

Eihiro Nakata：“机密手术/标准手术图集” Intermerk，252 (1991)