Study of vasoconstrictire protein in renal artery

观察了易卒中和难卒中自发性高血压大鼠（SHR、SHRSP）肾动脉血管蛋白的合成。POB和肾动脉和/或肠系膜动脉根部的手术或药物去神经支配的作用阻止了这些动物高血压的发展。上述血管中的氚化脯氨酸掺入也在抗高血压治疗后减少。肾动脉或肠系膜动脉中的^3H-脯氨酸掺入量与收缩压显著正相关，但在慢性高血压阶段，这种关系并不明显，基于这些发现，血管舒张活性蛋白，特别是非胶原蛋白和胶原似乎具有血管舒张活性。在临床上，高血压患者的非胶原蛋白和胶原蛋白含量较高。

Synthesis of vascular protein was investigated in renal arteries of stroke-prone and-resistant spontaneously hypertensive rats (SHR, SHRSP). The effect of POB and surgical or pharmacological denervation of the root of the renal and/or mesenteric arteries prevented the development of hypertension of these animals. Incorporation of tritiated proline into the vessels described above were also decreased following the antihypertensive treatments. Positive correlations of ^3H-proline incorporation into the renal or mesenteric artery and systolic blood pressure were remarkably noted.However, in chronic hypertensive stages, these relationship were not observed.Based on these findings, vasoconstractive protein, especially non-collagenous protein and collagen appear to possess a vasoconstractive capability. These connective tissue protein was probably mediated neural factors.In clinical patients, contents of non-collagenous protein and collagen revealed to be high in hypertensive patients.