Study of pathogenesis of adrenal-regeneration hypertension with special reference to vascular protein synthesis

1)肾上腺再生高血压（ARH）大鼠慢性期心脏胶原蛋白中^ 3h -脯氨酸的掺入显著增加。α 1受体阻滞剂的施用有效地抑制了这种蛋白的合成，同时降低了血压。^ 3h -脯氨酸与心脏弹性蛋白的结合保持不变。在高血压ARH大鼠的肠系膜动脉中也得到了类似的结果。盐负荷大鼠单侧肾切除和双侧肾上腺去核诱发高血压（ARH）。去氧皮质酮（DOCA）治疗可进一步增强ARH大鼠胶原蛋白和非胶原蛋白的掺入，并迅速发展为显著的高血压。受体阻滞剂的使用未能减少高血压血管蛋白的合成，而血管胶原蛋白和非胶原蛋白在高血压的发病机制中起着重要作用。2)测定人肾动脉和睾丸动脉中胶原蛋白、非胶原蛋白和弹性蛋白的含量。高血压患者睾丸动脉中存在大量非胶原蛋白。血压与非胶原蛋白含量呈线性正相关。这些结果表明，睾丸动脉合成的增加似乎会使人的血压升高。3)我们对原发性醛固酮增多症患者的随访研究表明，肿瘤未受累的肾上腺皮质在11个月后再生。除了内分泌分析外，该研究还通过CT或闪烁成像显示部分切除的腺体。

1) Increased incorporation of ^3H-proline into the collagen in the heart was remarkable in the chronic phase of adrenal-regeneration hypertensive (ARH) rats. Administration of alpha 1 blocker effectively suppressed such protein synthesis concomitant with reduction of blood pressure. Incorporation of ^3H-proline into the cardiac elastin remained unchanged. Similar results were also obtained in the mesenteric arteries in hypertensive ARH rats. Unilateral nephrectomy and bilateral adrenal enucleation in salt-loaded rats evoked hypertension (ARH). Treatment with desoxycorticosterone (DOCA) too ARH rats further enhanced incorporation into the collagen and non-collagenous protein in such DOCA-treated ARH rats with rapid development of remarkable hypertension. Administration of beta blocker failed to reduce such vascular protein synthesis and hypertension vascular collagen and non-collagenous protein play and important role for the pathogenesis hypertension.2) Collagen, non-collagenous protein and elastin were determinde in renal and testicular arteries in humons. High amount of non-collagenous protein was noted in the testicular arteries in hypertensive patients. Linear postine relationship was seen between blood pressure and the content of non-collatenous protein. These results indicate that increased synthesis of testicular arteries appears to raise the blood pressure in human beings.3) Our follow-up study of patients with primary aldosteronism showed that tumor-uninbolved adrenal cortex regenerated in 11monthes. Such study was done by visualization of the partiaally resected gland by CT or scintigraphy in addition to endocrine analysis.