权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study of pathogenesis of adrenal-regeneration hypertension with special reference to vascular protein synthesis

肾上腺再生性高血压发病机制的研究，特别涉及血管蛋白合成

基本信息

批准号：
08457420
负责人：
NAKADA Teruhiro
金额：
$ 4.22万
依托单位：
Yamagata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457420/
关键词：
adrenal hypertension collagen elastin

项目摘要

1) Increased incorporation of ^3H-proline into the collagen in the heart was remarkable in the chronic phase of adrenal-regeneration hypertensive (ARH) rats. Administration of alpha 1 blocker effectively suppressed such protein synthesis concomitant with reduction of blood pressure. Incorporation of ^3H-proline into the cardiac elastin remained unchanged. Similar results were also obtained in the mesenteric arteries in hypertensive ARH rats. Unilateral nephrectomy and bilateral adrenal enucleation in salt-loaded rats evoked hypertension (ARH). Treatment with desoxycorticosterone (DOCA) too ARH rats further enhanced incorporation into the collagen and non-collagenous protein in such DOCA-treated ARH rats with rapid development of remarkable hypertension. Administration of beta blocker failed to reduce such vascular protein synthesis and hypertension vascular collagen and non-collagenous protein play and important role for the pathogenesis hypertension.2) Collagen, non-collagenous protein and elastin were determinde in renal and testicular arteries in humons. High amount of non-collagenous protein was noted in the testicular arteries in hypertensive patients. Linear postine relationship was seen between blood pressure and the content of non-collatenous protein. These results indicate that increased synthesis of testicular arteries appears to raise the blood pressure in human beings.3) Our follow-up study of patients with primary aldosteronism showed that tumor-uninbolved adrenal cortex regenerated in 11monthes. Such study was done by visualization of the partiaally resected gland by CT or scintigraphy in addition to endocrine analysis.

1)肾上腺再生性高血压(ARH)大鼠慢性期心脏胶原~(3 H)-Pro掺入显著增加。服用α1阻滞剂有效地抑制了这种蛋白质合成，同时伴随着血压的降低。~(3 H)-Pro掺入心脏弹性蛋白未见变化。高血压ARH大鼠肠系膜动脉也有类似的结果。盐负荷大鼠单侧肾切除双侧肾上腺摘除诱发高血压(ARH)。经脱氧皮质酮(DOCA)治疗的ARH大鼠高血压迅速发展，经DOCA治疗后，ARH大鼠的胶原和非胶原蛋白的掺入进一步增加。应用β受体阻滞剂不能减少这种血管蛋白的合成，血管胶原和非胶原蛋白在高血压的发病机制中起着重要作用。2)测定人肾动脉和睾丸动脉中的胶原、非胶原蛋白和弹性蛋白。高血压病患者睾丸动脉中非胶原蛋白含量较高。血压与非胶原蛋白含量呈直线正相关。这些结果表明，睾丸动脉合成的增加似乎提高了人类的血压。3)我们对原发性醛固酮增多症患者的随访研究显示，肿瘤未闭塞的肾上腺皮质在11个月内再生。除了内分泌分析外，这种研究还通过CT或闪烁成像对部分切除的腺体进行可视化。