A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS

综合外推研究--人类与实验动物的基因同源性

• 批准号: 04304052
• 负责人: KASAI Noriyuki
• 金额: $ 9.6万
• 依托单位: TOHOKU UNIVERSITY (1994)Hokkaido University (1992-1993)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04304052/
• 关键词: EXTRAPOLATION; SPECIES DIFFERENCES; GENE; PHARMACOKINETICS; GENETIC HOMOLOGY; LABORAATORY ANIMALS; STRAIN DIFFERENCES; ANIMAL SCALE UP; 遺伝的相同性; 遺伝情報; 薬物代謝酵素; 薬物代謝能; 疾患遺伝子; 膜酵素; 肝臓薬物代謝酵素; 遺伝子地図; ジーンバンク; 動物脳シナプス膜脂質

EXTRAPOLATION MEANS TO PRESUME THE RESULTS ON HUMAN BEINGS FROM THE RESULTS OF EXPERIMENTATION USING LABORATORY ANIMALS.HOWEVER,AN ACCURATE EXTRAPOLATION IS PREVENTED BY THE SPECIES DIFFERENCES BETWEEN HUMAN BEINGS AND ANIMALS.WE INVESTIGATED THE WAY OF EXTRAPOLATION BY THE COMPARISON OF THE PHARMACOKINETICS AND THE GENETIC ANALYSIS BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS.THIS RESEARCH LASTED FOR THREE YEARS,AND WE DEVELOPED NEW FIELD FOR LABORATORY ANIMAL SCIENCE.BUT MORE RESEARCH IS NEEDED FOR ESTABLISHMENT OF THE NEW METHODS OF EXTRAPOLATION.WE HELD A SYMPOSIUM ON THE EXTRAPOLATION AT TOKYO,AND ABOUT 250 RESEARCERS PARTICIPATED IN THIS SYMPOSIUM.I THINK THIS IS FIRST SYMPOSIUMON THE EXTRAPOLATION IN JAPAN.

外推法是指根据实验动物的实验结果推测人体的结果，但由于人与动物的种属差异，难以准确外推。本文通过人与实验动物药代动力学比较和遗传分析，阐明了外推法的可行性。本研究历时三年，我们为实验室动物科学开辟了新的领域。但是需要更多的研究来建立新的外植方法。我们在东京举行了一个关于外植的研讨会，大约有250名研究人员参加了这次研讨会。我想这是日本第一次关于外植的研讨会。

项目成果

"Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation" Am.J.Physiol. 35. 392-399 (1994)

“β-内酰胺抗生素通过脉络丛从脑脊液主动流出进入循环系统的动力学”Am.J.Physiol。

Yamashita,T.,: "Evidence that alha-fetoprotein suppresses the immunological function in transgenic mice.," Biochem.Biophys.Res.Commun.201(3). 1154-1159 (1994)

Yamashita,T.，：“有证据表明甲胎蛋白抑制转基因小鼠的免疫功能。”Biochem.Biophys.Res.Commun.201(3)。

杉山雄一: "Kinetics of active efflux via choroid plexus of β-lactam antibiotics from the CSF into the circulation.," Am.J.Physiol.35. 392-399 (1994)

Yuichi Sugiyama：“β-内酰胺抗生素通过脉络丛从脑脊液进入循环系统的主动流出动力学”，Am.J.Physiol.35（1994）。

Osanai, T., Miyoshi, I., et al.: "Spontaneous urinary calculus in Young LEW rats caused by corynebacterium renale." J.Urology. 152. 1002-1004 (1994)

Osanai, T.、Miyoshi, I. 等人：“由肾棒杆菌引起的幼年 LEW 大鼠自发性尿路结石。”

Hayashiazki, Y., Hirotsune, S., Okazaki, Y., et al.: "A Genetic linkage map of the mouse using Restriction Landmark Genomic Scanning(RLGS)." Genetics. in press. (1994)

Hayashiazki, Y.、Hirotsune, S.、Okazaki, Y. 等人：“使用限制性地标基因组扫描 (RLGS) 绘制的小鼠遗传连锁图。”