A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS
A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS
批准号:
04304052
负责人:
KASAI Noriyuki
金额:
$9.6万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Co-operative Research (A)
财政年份:
1992
资助国家:
日本
项目状态:
已结题
起止时间:
1992 至 1994
中文摘要
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英文摘要
EXTRAPOLATION MEANS TO PRESUME THE RESULTS ON HUMAN BEINGS FROM THE RESULTS OF EXPERIMENTATION USING LABORATORY ANIMALS.HOWEVER,AN ACCURATE EXTRAPOLATION IS PREVENTED BY THE SPECIES DIFFERENCES BETWEEN HUMAN BEINGS AND ANIMALS.WE INVESTIGATED THE WAY OF EXTRAPOLATION BY THE COMPARISON OF THE PHARMACOKINETICS AND THE GENETIC ANALYSIS BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS.THIS RESEARCH LASTED FOR THREE YEARS,AND WE DEVELOPED NEW FIELD FOR LABORATORY ANIMAL SCIENCE.BUT MORE RESEARCH IS NEEDED FOR ESTABLISHMENT OF THE NEW METHODS OF EXTRAPOLATION.WE HELD A SYMPOSIUM ON THE EXTRAPOLATION AT TOKYO,AND ABOUT 250 RESEARCERS PARTICIPATED IN THIS SYMPOSIUM.I THINK THIS IS FIRST SYMPOSIUMON THE EXTRAPOLATION IN JAPAN.
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"Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation" Am.J.Physiol. 35. 392-399 (1994)
“β-内酰胺抗生素通过脉络丛从脑脊液主动流出进入循环系统的动力学”Am.J.Physiol。
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Yamashita,T.,: "Evidence that alha-fetoprotein suppresses the immunological function in transgenic mice.," Biochem.Biophys.Res.Commun.201(3). 1154-1159 (1994)
Yamashita,T.,:“有证据表明甲胎蛋白抑制转基因小鼠的免疫功能。”Biochem.Biophys.Res.Commun.201(3)。
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杉山雄一: "Kinetics of active efflux via choroid plexus of β-lactam antibiotics from the CSF into the circulation.," Am.J.Physiol.35. 392-399 (1994)
Yuichi Sugiyama:“β-内酰胺抗生素通过脉络丛从脑脊液进入循环系统的主动流出动力学”,Am.J.Physiol.35(1994)。
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Osanai, T., Miyoshi, I., et al.: "Spontaneous urinary calculus in Young LEW rats caused by corynebacterium renale." J.Urology. 152. 1002-1004 (1994)
Osanai, T.、Miyoshi, I. 等人:“由肾棒杆菌引起的幼年 LEW 大鼠自发性尿路结石。”
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Hayashiazki, Y., Hirotsune, S., Okazaki, Y., et al.: "A Genetic linkage map of the mouse using Restriction Landmark Genomic Scanning(RLGS)." Genetics. in press. (1994)
Hayashiazki, Y.、Hirotsune, S.、Okazaki, Y. 等人:“使用限制性地标基因组扫描 (RLGS) 绘制的小鼠遗传连锁图。”
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共 30 条
The analyses of role of copper on the diabetes in the animal model with diabetes and copper metabolism deficiency
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批准号:18500324
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:KASAI Noriyuki
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依托单位:
Establishment of support network system for the technology of gene alternated mice production and embryonic manipulation by closer cooperation with academic and industrial fields
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批准号:12794020
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项目类别:Grant-in-Aid for University and Society Collaboration
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资助金额:$19.78万
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财政年份:2000
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负责人:KASAI Noriyuki
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依托单位:
Production and analyses of diverse models for human Wison's disease
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批准号:09480244
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:1997
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负责人:KASAI Noriyuki
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依托单位:
Production and Charactrerization of New Conjenic strain of LEC rats which is a Model for Spontaneous Hepatits and Hepatoma
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批准号:07558237
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$0.7万
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财政年份:1995
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负责人:KASAI Noriyuki
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依托单位:
The establishment of the standard method for rat embryo-cryopreservation method and for the network.
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批准号:04558012
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$3.46万
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财政年份:1992
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负责人:KASAI Noriyuki
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依托单位:
A Research for cryopreservation and transportation of embryos of small lsboratory animals.
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批准号:02558008
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$2.62万
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财政年份:1990
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负责人:KASAI Noriyuki
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依托单位:
海外基金