Characterising the innate immune response to decellularised extracellular matrix-based heart valve and aortic implants (C04*)

表征对基于脱细胞细胞外基质的心脏瓣膜和主动脉植入物的先天免疫反应（C04*）

• 批准号: 525462594
• 金额: --
• 依托单位: Institut für Experimentelle Hämatologie und Transfusionsmedizin (IHT)
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/525462594?language=en
• 关键词: Characterising; innate; immune; response; decellularised

Decellularised human heart valves (DHV) are a promising therapeutic approach for heart valve replacement in terms of biocompatibility and durability. Nonetheless, early and late degeneration of aortic DHVs has been observed in some patients, with several studies implicating the immune response to the decellularised extracellular matrix (dECM) in this process. In this project, we aim to characterise the immune response to dECM graft material and investigate how its modulation may affect host integration of dECM-based implants. Altogether, we hope to establish the molecular groundwork for targeted pharmacological therapies to improve integration, biocompatibility, and durability of DHVs.

就生物相容性和耐久性而言，脱细胞人心脏瓣膜（DHV）是一种很有前景的心脏瓣膜置换治疗方法。尽管如此，在一些患者中观察到了主动脉 DHV 的早期和晚期变性，一些研究表明在此过程中对脱细胞细胞外基质 (dECM) 的免疫反应。在这个项目中，我们的目标是表征对 dECM 移植材料的免疫反应，并研究其调节如何影响基于 dECM 的植入物的宿主整合。总而言之，我们希望为靶向药物治疗奠定分子基础，以提高 DHV 的整合性、生物相容性和耐久性。