"Development of system for diagnosis of early-stage arteriosclerosis using ultrasound"

“开发利用超声波诊断早期动脉硬化的系统”

• 批准号: 05555108
• 负责人: CHUBACHI Noriyoshi
• 金额: $ 6.98万
• 依托单位: Faculty of Engineering, Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05555108/
• 关键词: atherosclerosis; local elastic characteristics; ultrasonic measurements; non-invasive measurement; ultrasonic Doppler method; pulse wave velocity; small vibration measurements; early-stage diagnosis of arteriosclerosis; 脈波伝搬特性; 弾性特性; スペクトル解析; 早

In this research, we have developed a new method to measure local pulse wave velocity, which is an index of the hardness in the range of several millimeters on the aortic wall. In the standard method, the pulse wave velocity (PWV) is obtained from the difference in arrival time of pressure waves propagating from the carotid artery to the femoral artery. In this method, the measurable points are limited to those where the aorta exists near the skin surface and the distance between such points is considerable long, i.e., several hundred millimeters. It is important for early diagnosis, however, to measure the local hardness of the surface of the arterial wall. To increase the spatial resolution, it is necessary to measure vibrations due to pulse waves with frequency components up to about 50 Hz.Therefore, we have developed a new system to noninvasively measure small vibration signals on the heart wall or the aortic wall from the surface of the skin based on the ultrasonic Doppler effect. … More By this system, small vibrations with amplitudes of 10 - 100 mum on the motion due to heart beat with the large amplitude of 10 mm are successfully detected in the frequency range up to 1 kHz continuously for more than ten beat periods from the chest.This research also developed a new method for obtaining local PWV by simultaneously measuring small vibrations at two points on the surface of the tube wall and the aortic wall. By the developed method, high spatial resolution, which is necessary in the evaluation of local hardness, is attained. By comparing the static experiments and dynamic experiments using a silicon tube, it is confirmed that the local hardness (Young's modulus) of the vessel wall is also evaluated with high spatial resolution.By applying the developed system and the method to in vivo experiments, the PWV of the vibration wave transmitted between the two points on the aortic wall is obtained even for the aortic wall near the aortic valve. The distance between the two points is about several millimeters. The local elasticity (Young's modulus) is also evaluated for each measurement point. Thus, the developed system will be effective for local evaluation of the hardness on the aortic wall. Less

在这项研究中，我们开发了一种测量局部脉搏波速度的新方法，它是主动脉壁几毫米范围内的硬度指标。在标准方法中，脉搏波速度（PWV）是根据从颈动脉传播到股动脉的压力波的到达时间差获得的。在该方法中，可测量的点仅限于主动脉位于皮肤表面附近的点，并且这些点之间的距离相当长，即数百毫米。然而，测量动脉壁表面的局部硬度对于早期诊断很重要。为了提高空间分辨率，需要测量频率成分高达约50 Hz的脉搏波引起的振动。因此，我们开发了一种新系统，基于超声波多普勒效应，从皮肤表面无创地测量心壁或主动脉壁上的微小振动信号。 ... 更多 通过该系统，成功地在高达 1 kHz 的频率范围内连续检测胸部十多个搏动周期内由于 10 mm 大振幅的心跳而产生的 10 - 100 mum 的运动振幅小振动。该研究还开发了一种通过同时测量管壁和主动脉壁表面两点的小振动来获取局部 PWV 的新方法。通过所开发的方法，获得了评估局部硬度所需的高空间分辨率。通过比较静态实验和使用硅管的动态实验，证实血管壁的局部硬度（杨氏模量）也可以以高空间分辨率进行评估。通过将开发的系统和方法应用于体内实验，即使对于主动脉瓣附近的主动脉壁，也可以获得主动脉壁上两点之间传输的振动波的PWV。两点之间的距离约为几毫米。还评估每个测量点的局部弹性（杨氏模量）。因此，所开发的系统将有效地评估主动脉壁的硬度。较少的

项目成果

H.Kanai,T.Hori,N.Chubachi,T.Ono: "Delayed Block Transfer Function and its Application to Accurate Es-timation of Transfer Function" IEEE Transctions on Signal Processing. 41. 1669-1684 (1994)

H.Kanai、T.Hori、N.Chubachi、T.Ono：“延迟块传递函数及其在传递函数精确估计中的应用”IEEE 信号处理交易。

H.Kanai,H.Satoh,K.Hirose,N.Chubachi: "“A New Method for Measuring Small Local Vibrations in the Heart Using Ultrasound"" IEEE Transactions on Biomedical Engineering.40. 1233-1242 (1993)

H. Kanai、H. Satoh、K. Hirose、N. Chubachi：“使用超声波测量心脏局部小振动的新方法””IEEE 生物医学工程汇刊.40 (1993)。

高野正彦,金井 浩,中鉢憲賢,小岩喜郎,手塚文明,高橋光浩: "動脈硬化の局所診断のための血管壁上微小振動の計測と解析" 日本音響学会誌. 51. 174-181 (1995)

Masahiko Takano、Hiroshi Kanai、Kenken Chubachi、Yoshiro Koiwa、Fumiaki Tezuka、Mitsuhiro Takahashi：“用于动脉硬化局部诊断的血管壁微小振动的测量和分析”日本声学学会杂志 51. 174-181（1995 年）。 ) )

村田亮治,金井 浩,中鉢憲賢,小岩喜郎,竹内康人: "動脈硬化の非侵襲的診断を目指した超音波ビームの制御による動脈壁上2点での微小振動の計測" 日本超音波医学会誌. 21. 703-711 (1994)

Ryoji Murata、Hiroshi Kanai、Kenken Chubachi、Yoshiro Koiwa、Yasuto Takeuchi：“通过控制超声波束测量动脉壁上两点的微小振动，用于动脉硬化的无创诊断”《日本超声医学杂志》21. 703-711（ 1994）

佐藤宏明,金井 浩,中鉢憲賢,小岩喜郎: "心臓疾患の非侵襲的診断を目指した超音波ドプラによる心臓壁微小振動の解析" 日本超音波医学会誌. 22(印刷中). (1995)

Hiroaki Sato、Hiroshi Kanai、Kenken Chubachi、Yoshiro Koiwa：“使用多普勒超声对心脏壁的微小振动进行分析，用于心脏病的无创诊断”，日本医学超声学会杂志 22（出版中）。 1995)