"Research on noninvasive and quantitative measurement of small vibration in myocardium for early stage diagnosis of heart diseases"

“无创定量测量心肌微小振动用于心脏病早期诊断的研究”

• 批准号: 08405031
• 负责人: CHUBACHI Noriyoshi
• 金额: $ 10.43万
• 依托单位: Tohoku Gakuin University (1997)Tohoku University (1996)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08405031/
• 关键词: myocardial elastic characterstics; cardiomyopathy; spectrum analysis; ultrasonic diagnosis; non-invasive diagnosis; ultrasonic Doppler method; small vibration measurements; diseases of circulatory system; 心臓疾患; 動脈硬化症; 心内圧; 早期診断; 振動計測; 微小振動

In this research, we have developed a new system to accurately measure small vibration signal on the heart wall. By this method, small vibrations of the heart wall with small amplitudes less than 100 mum on the motion resulting from a heartbeat with large amplitude of 10mm can be successfully detected with suflicient reproducibility in the frequency range up to several hundred Hertz continuously for periods of about ten heartbeats. The resultant small vibration is analyzed not only in the time domain but also in the frequency domain. As confirmed by the experiments herein reported, the new method offers pontential for research in acoustical diagnosis of heart diseases.In this research, the method is applied to multiple points preset in the left ventricular (LV) wall along the ultrasonic beam so that the spetial (depth) distributions of the velocity at these points are simultaneously obtained. The motion of the heart wall is divided into the following two components : parallel global motion of the heart wall and the change in myocardial layr thickening at each depth across the LV wall during myocardial contraction/relaxation. The latter component is superimposed on the M (motion) -mode image using a color cude to map contraction as red and expansion as blue. By preliminary human studies, the principle of the method proposed in this paper is verified and the frequency band of the components generated by thickening and/or thinning in the myocardium is identified. This new approach offers potential for research on noninvasive acoustical diagnosis of myocardial local motility, that is, the myocardial layr function at each depth in the ventricular wall.

在这项研究中，我们开发了一个新系统，可以准确测量心脏壁上的小振动信号。通过这种方法，可以成功检测到大约十个心脏的频率范围内，在频率范围内连续数百个赫尔兹，可以成功检测到大约10 hertz的心脏振幅，幅度大于10mm的心跳导致的运动幅度小于100妈妈的心脏壁的小振动。不仅在时域，而且在频域中分析了所得的小振动。正如本文报道的实验所证实的那样，新方法为心脏病的声学诊断研究提供了宽大的研究。在这项研究中，该方法沿超声梁沿左心室（LV）壁中的多个点预设，以便同时获得这些点的速度分布的孢子（深度（深度）分布）。心脏壁的运动分为以下两个组成部分：心脏壁的平行全局运动以及在心肌收缩/放松期间，在LV壁上每个深度的心肌层增厚。后一个组件使用颜色的cude叠加在M（运动）模式图像上，以将收缩和膨胀为蓝色。通过初步的人类研究，验证了本文提出的方法的原理，并确定了通过心肌中增厚和/或变薄产生的成分的频带。这种新方法提供了研究心肌局部运动的无创声学诊断的潜力，也就是说，在心室壁中的每个深度处的心肌外行功能。

项目成果

H. Kanai, M. Sato, Y. Koiwa, and N. Chubachi:""Transcutaneous Measurement and Spectrum Analysis of Heart Wall Vibrations,"" IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.43・5. 791-810 (1996)

H. Kanai、M. Sato、Y. Koiwa 和​​ N. Chubachi：“心壁振动的经皮测量和频谱分析”​​，IEEE Transactions on Ultrasonics、Ferroelectrics 和频率控制。43・5。 1996）

Hiroshi Kanai, Hideyuki Hasegawa, Noriyoshi Chubachi, Yoshiro Koiwa, and Motonao Tanaka: "Noninvasive Evaluation of Local Myocardial Thickening and Its Color-Coded Imaging" IEEE Transaction on Ultrasonics, Ferroelectrics, and Freguency Control.Vol.44, No.

Hiroshi Kanai、Hideyuki Hasekawa、Noriyoshi Chubachi、Yoshiro Koiwa 和​​ Motonao Tanaka：“局部心肌增厚及其颜色编码成像的无创评估”IEEE Transaction on Ultrasonics, Ferroelectrics, and Freguency Control.Vol.44，No.

Hideyuki Hasegawa, Hiroshi Kanai, Noriyoshi Chubachi, Yoshiro Koiwa: "Evaluation of local elastic characteristics by accurte nonin vasive measuurement of small vibrations on arterial wall" The Journal of Acoustical Societyof Japan. Vol.53, No.5(May). 346-

Hideyuki Hasekawa、Hiroshi Kanai、Noriyoshi Chubachi、Yoshiro Koiwa：“通过精确非侵入性测量动脉壁小振动来评估局部弹性特性”日本声学学会杂志。

中屋重光,金井浩,中鉢憲賢: "胸壁から計測した心臓壁微小振動の解析による拡張末期圧と心筋弾性値の非侵襲的計測" J.Medical Ultrasonics. 24・9. 1468- (1997)

Shigemitsu Nakaya、Hiroshi Kanai、Kenken Chubachi：“通过分析从胸壁测量的心壁的微小振动来无创测量舒张末期压力和心肌弹性”J.Medical Ultrasonics 24・9。 ）

長谷川英之,金井浩,中鉢憲賢,小岩喜朗: "動脈壁厚変化の非侵襲的高精度計測による動脈壁弾性率の評価" J.Medical Ultrasonics. 24・6. 851-860 (1997)

Hideyuki Hasekawa、Hiroshi Kanai、Kenken Chubachi 和 Yoshiro Koiwa：“通过非侵入性高精度测量动脉壁厚度变化来评估动脉壁弹性模量”J.Medical Ultrasonics 24・6。