Studies on bioultrasonic micro-spectroscopy

生物超声显微光谱学（Bio-UMS）有望成为生物科学和医学应用研究领域的一种新方法。生物软组织和硬组织在微观尺度上的粘弹性可以通过Bio-UMS技术使用VHF和UHF范围内的体超声波和聚焦超声波进行研究。用于Bio-UMS的系统和方法已经开发如下：1.为了利用纵波获得软组织和液体的体声波特性，已经开发了一种在1 MHz到1GHz的频率范围内工作的生物超声光谱方法和系统。以水为参考介质，用超声透射比较法可以同时高精度地测定衰减、速度、阻抗和密度等频率特性。测定了蓖麻油、硅油和蓖麻油的衰减、速度、阻抗和密度等声学特性，并与透射比较法进行了比较。结果表明，超声透射比较法可以同时测定密度、衰减、速度、阻抗和密度等频率特性。 ...更多信息 在2到500 MHz的范围内由系统确定。在20 ~ 300 MHz范围内成功地测量了油的速度色散，首次在20 ~ 200 MHz范围内同时测量了牛肝、心肌和脂肪的四个参数。研究表明，肝脏和心肌组织声学特性的差异可以用它们的蛋白质含量来解释.已经开发了一种使用剪切波来确定声学特性的方法和系统。在5 ~ 300 MHz频率范围内获得了甘油和硅油的剪切波特性，并具有足够的精度.一种新的方法和系统已经开发出来，以获得在VHF和UHF范围内使用超声纵波的液体的非线性特性。首次在基频100 ~ 180 MHz范围内测定了糖水溶液的非线性参数.研制了一种具有成像和定量测量双重功能的高分辨率定向点聚焦声显微镜系统，用于牙齿和骨骼硬组织的研究。少

Bioultrasonic micro-spectroscopy (Bio-UMS) is expected to be developed as a new methodology in the research fields of biological science and medical applications. Viscoelastic properties of biological soft and hard tissues on a microscopic scale can be investigated by Bio-UMS technology using bulk and focused ultrasonic waves in the VHF and UHF ranges. Systems and methods for Bio-UMS have been developed as follows :1. A bioultrasonic spectroscopy method and system, operating in the frequency range from 1MHz to 1GHz, has been developed in order to obtain bulk acoustic properties of soft tissues and liquids using longitudinal waves. The frequency characteristics of attenuation, velocity, and impedance, and the density can be determined simultaneously with high accuracy by an ultrasonic transmission comparison method wherein the reference medium is water.The acoustic properties of attenuation, velocity, impedance, and density of castor oil, silicone oil, and conttonseed oil have been dete … More rmined in the range 2 to 500MHz by the system. Measurements of velocity dispersion have been demonstrated successfully for the oils in the range 20 to 300MHz.Four paramenters of bovine liver, heart muscle, and fat have been determined simultaneously for the first time in the range 20 to 200MHz. It has been shown that the differences between the acoustic properties of liver and heart muscle tissues can be explained by their protein contents.2. A method and system to determine acoustic properties using shear waves has been developed. The shear wave properties of glycerol and silicone oil have been obtained in the range 5 to 300MHz with sufficient accuracy.3. A new method and system has been developed to obtain nonlinear properties of liquids in the VHF and UHF ranges using ultrasonic longitudinal waves. Nonlinear parameters have been determined for aqueous solutions of sugars in the fundamental frequency range 100 to 180MHz for the first time.4. A high resolution directional point-focus-beam acoustic microscope system with two functions of imaging and quantitative measurements has been developed to in investigate hard tissues of teeth and bones. Less