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"Development of ultrasonic diagnosis system for early-stage arteriosclerosis using impulsive actuator"

“利用脉冲执行器开发早期动脉硬化超声诊断系统”

基本信息

批准号：
07555124
负责人：
CHUBACHI Noriyoshi
金额：
$ 6.27万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

In this research, we have developed a new method to measure local pulse wave velocity, which is an index of the hardness in the range of several millimeters on the aortic wall. In the standard method, the pulse wave velocity (PWV) is obtained from the difference in arrival time of pressure waves propagating from the carotid artery to the femoral artery. In this method, the measurable points are limited to those where the aorta exists near the skin surface and the distance between such points is considerable long, i. e., several hundred millimeters. It is important for early diagnosis, however, to measure the local hardness of the surface of the arterial wall. To increase the spatial resolution, it is necessary to measure vibrations due to pulse waves with frequency components up to about 50 Hz.Therefore, we have developed a new system to noninvasively measure small vibration signals on the heart wall or the aortic wall from the surface of the skin based on the ultrasonic Doppler effect. By this system, small vibrations with amplitudes of 10-100mum on the motion due to heart beat with the large amplitude of 10 mm are successfully detected in the frequency range up to 1 kHz continuously for more than ten beat periods from the chest.To improve the spatial resolution in the local velocity measurement of vibration propagating on the arterial wall, this research also developed a new method to actuate impulsive wave with higher frequency components until 1 kHz from the backbone and transcutaneously measure the transit delay time of the impulsive wave propagating two proximate points on the aortic wall. The method offers potential for research in acoustical diagnosis of arteriosclerosis.

在这项研究中，我们开发了一种新的方法来测量局部脉搏波速度，这是一个指数的硬度范围内的几毫米的主动脉壁。在标准方法中，根据从颈动脉传播到股动脉的压力波的到达时间差获得脉搏波速度（PWV）。在该方法中，可测量点仅限于主动脉存在于皮肤表面附近的那些点，并且这些点之间的距离相当长，即。例如，几百毫米然而，测量动脉壁表面的局部硬度对于早期诊断是重要的。为了提高空间分辨率，需要测量频率成分高达约50 Hz的脉搏波引起的振动，因此，我们开发了一种新的系统，该系统基于超声多普勒效应从皮肤表面无创地测量心脏壁或主动脉壁上的微小振动信号。通过该系统，成功地检测了在高达1 kHz的频率范围内从胸部连续超过10个搏动周期的由具有10 mm的大幅度的心脏搏动引起的运动中的具有10- 100 μ m幅度的小振动。本研究还开发了一种新的方法，激励具有更高频率分量的脉冲波，直到主动脉主干的1 kHz，并transmitted测量脉冲波在主动脉壁上传播的两个邻近点的传播延迟时间。该方法为动脉硬化声学诊断的研究提供了可能。