Comparative study on lymphoid malignancy between Jap。 & China -A cytogenetic and molecular biological study -

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The incidence of non-Hodgkin's lymphoma (NHL) in Japan is one-half of that in the USA. The present study was under taken to understand the incidence of follicular lymphoma and chronic lymphocyte leukemia in Japan and India in comparison to the data from the western countries, and also to investigate the differences among these countries in cytogenetic and molecular genetic findings.1)Cytogenetic analysis of 73 Japanese NHL cases revealed a lower incidence of 14 ; 18 translocation among follicular lymphoma (40%), compared with the incidence in American cases (75-88%). Japanese CLL cases had almost the same incidence of karyotype abnormalities (45.8%, 51.5%, in USA) and types of abnormalities as American cases (trisomy 12, 14q and 13q abnormalities).However, a higher incidence of complex karyotype was found in Japanese cases than that of western countries (p<0.05).2)The incidence of BCL-2 rearrangement in Japanese/Indian follicular lymphoma was less than that of American cases (45.2% vs 90% USA cases in reports) by Southern blotting, 10.9% vs 53.4% USA cases by PCR. The incidence of BCL-2 rearrangement was not different between that of Japanese and American CLL cases (5.7% vs 6.8-9.3%).3)Detection of trisomy 12 and RB gene loss by means of FISH method in CLL cases revealed that American and Indian cases had a higher incidence of trisomy 12 than that of Japanese cases (30-42.9% vs 19%), whereas RB gene loss of Indian cases (39%) was not significantly different from Japanese cases (28.6%). In general, Indian cases showed almost the same biological characteristics of Japanese B-cell malignancies, although there exists some differences with the American and European cases.