Studies on the difference in the circumstances and the diseases between Japanese and Chinese

日本人和中国人的环境和疾病差异研究

• 批准号: 05045047
• 负责人: OKADA Yoshio
• 金额: $ 1.28万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05045047/
• 关键词: Hypertension; Cardiac hypertrophy; Cine MRI; Echocardiography; Hemodynamics

Studies on the effects of various hypotensive drugs on left ventricular myocardial hypertrophy primarily by echocardiography have shown that calcium antagonists, angiotensin-converting enzyme inhibitors, alpha_2-blockers, and central sympatholytic drugs are effective for attenuating the condition, but that the effects of beta-blockers are unpredictable, and diuretics and direct vasodilators have no effects. However, the effects of hypotensive drugs have been suggested to vary among races, and there have been few studies in which the effects of hypotensive drugs on cardiac hypertrophy were compared internationally. Also, MRI has attracted attention as a method for measurement of the left ventricular weight, and comparison of the findings by MRI with those by conventional electrocardiography and echocardiography is interesting. This study is designed to evaluate anti-cardiac hypertrophy effects of various hypotensive drugs in Japanese and Chinese subjects by MRI as well as by echocaardio … More graphy and MRI.Objectives : Using cinemagnetic resonance imaging(MRI)and echocardiography(ECHO), we studied the effects of TCV-116, a specific antagonist for angiotensin II subtype 1 receptors, on hemodynamics and cardiac hypertrophy in patients with essential hypertension.Subjects and Methods : Twelve patients with essential hypertension received oral TCV-116 after a control period of placebo administration. Cine MRI images were acquired in the axial plane with a gradientecho technique, GRASS, with echo time of 13 msec, repetition time of 66 msec, and flip angle of 20 degrees. Simpson's rule was used forleft ventricular volume and mass measurements by MRI. Left ventricular volumes by ECHO were calculated using Teichholz's formula. Left ventricular mass(LVM)by ECHO was measured using American Society of Echocardiography measurements and the formula by Devereux et al. : LVM=0.8[1.04(IVS+LVID+PWT)^3-LVID^3)]+0.6g. (IVS : interventricularseptal thickness, PWT : posterior wall thickness, LVID : left ventricular internal dimension)Results : Final daily doses of TCV-116 were 8 mg in 7 patients, 4 mg in 3 patients and 2 mg in 2 patients. After TCV-116 administration, systolic BP decreased from 185*19(mean*SD)to 161*30 mmHg and diastolic BP from 108*10 to 96*13(n=12, p<0.005)while HR remained unchanged from 70*12 to 70*9 bpm(n=12, NS). Both MRI and ECHO revealed a significant decrease in LVM after TCV-116 administration(n=12, p<0.05). MRI revealed a significant decrease in TSR from 1888*473 to 1702*408 dynes-sec-cm^<-5>(n=11, p<0.05). No significant changes were observed in other hemodynamic parameters before and after TCV-116 administration.Conclusions : Inpatients with essential hypertension, TCV-116 administered orally at doses of 2-8 mg/day for 8-12 weeks reduced blood pressure and led to a regression of cardiac hypertrophy. No deficient changes were observed in other hemodynamic parameters.The above tests will be carried out and effects will be compared between Japanese and Chinese subjects in further studies. Less

Studies on the effects of various hypotensive drugs on left ventricular myocardial hypertrophy primary by echocardiography have shown that calcium antagonists, angiotensin-converting enzyme inhibitors, alpha_2-blockers, and central sympatholytic drugs are effective for attenuating the condition, but that the effects of beta-blockers are unpredictable, and diuretics and direct vasodilators have no effects.然而，已经提出降压药在种族之间有所不同，很少有研究在国际上比较了降压药对心脏肥大的影响。同样，MRI吸引了人们的注意，作为测量左心室重量的方法，并比较MRI与传统心电图和超声心动图的发现，很有趣。这项研究旨在评估MRI以及通过Echocaardio以及Echocaardio的日本和中国受试者的各种降压药的抗心肥力影响……更多的图形和MRI。目标：使用Cinemagnetic共鸣成像（MRI）和超声心动图（MRI）和超声心动图（ECHO）（echo），我们研究了TCV-116的特定敌人，一位特定的敌人，一位特定的敌人，是一位特定的敌人，，一名特定的敌人，是一种特定的敌人，是一种特定的敌人，启用了特定的敌人。基本高血压患者的血液动力学和心脏肥大。受试者和方法：在控制安慰剂后，十二例基本高血压患者接受了口服TCV-116。用梯形技术，草，回波时间为13毫秒，重复时间为66毫秒和20度的翻转角度，在轴向平面中获取了Cine MRI图像。 Simpson的规则被MRI使用了侧心体积和质量测量。使用Teichholz的公式计算出回声的左心室体积。通过美国超声心动图测量学会和Devereux等人的公式测量左心室质量（LVM）：LVM = 0.8 [1.04（IVS+LVID+PWT）^3-LVID^3）]+0.6G。 （IVS：介入的厚度，PWT：后壁厚度，LVID：左心室内部尺寸）结果：7例患者的最终每日TCV-116剂量为8 mg，3例患者为4毫克，2例患者为2毫克。 TCV-116给药后，收缩压从185*19（平均*SD）降低到161*30 mmHg，舒张压从108*10至96*13（n = 12，p <0.005），而HR保持不变从70*12至70*9 bpm（n = 12，n = 12，ns）。 MRI和ECHO均显示TCV-116给药后LVM显着降低（n = 12，p <0.05）。 MRI显示TSR从1888*473到1702*408 Dynes-Sec-Cm^<-5>（n = 11，p <0.05）显着下降。 TCV-116给药之前和之后的其他血液动力学参数未观察到显着变化。结论：具有必不可少的高血压的住院患者，以2-8 mg/天的剂量口服TCV-116，持续8-12周，降低了血压，导致了心脏肥大的回归。在其他血液动力学参数中未观察到不足的变化。将进行上述测试，并在进一步的研究中比较日本和中国受试者之间的影响。较少的

项目成果

I.Nakae,L.Quan,K.Hashimoto,Y.Sugimoto,T.Tsutamoto and M.Kinoshita: "Mechanism of the Vasodilatory Action of Nicorandil on Coronary Circulation in Dogs" Cardiovascular Drugs and Therapy. 8. 73-81 (1994)

I.Nakae，L.Quan，K.Hashimoto，Y.Sugimoto，T.Tsutamoto和M.Kinoshita：“尼可地尔对狗冠状动脉循环的血管舒张作用的机制”心血管药物和治疗。

I.Nakae, L.Quan, K.Hashimoto, Y.Sugimoto, T.Tsutamoto and M.Kinoshita: "Mechanism of the Vasodilatory Action of Nicorandil on Coronary Circulation in Dogs" Cardiovascular Drugs and Therapy. 8. 73-81 (1994)

I.Nakae、L.Quan、K.Hashimoto、Y.Sugimoto、T.Tsutamoto 和 M.Kinoshita：“尼可地尔对狗冠状动脉循环的血管舒张作用机制”心血管药物和治疗。