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Biostatistics : Development of Bacic Theory and Ist Application

生物统计学:基础理论发展与应用

基本信息

批准号：
05302064
负责人：
YANAGAWA Takashi
金额：
$ 8万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

[Analysis of Toxicological Data]. "Statistical Analysis of Toxicological Data" is published (Yoshimura, Ohashi) . This is the first book of this kind written in Japanese. Also published is the "Biostatistics in the Study of Toxicology" (Sakuma, Yanagawa, Yoshimura eds.) which is the proceedings of the first International Biostatistics Conference in the Toxicology. A new method for the determination the of the no-observed-adverse-effect level is developed. Statistical analysis of data in mutageneity assays in the case of rodent micronucleus assay is also explored.[Methodologies in Epidemiology]. "Biostatistics in Human Cancer" (Yanagawa, Ohashi, Tango, Yanagimoto eds.) which is the proceedings of the fourth Japan-US Biostatistics Conference in the Study of Human Cancer is published : also published is the "Statistics for medical Science" (Tango). These two publications have given an inmense effect to researchers in the field of medical science. Mantel-Haenszel estimators are generalized … More for 2xJ table (J>2) . A statistical test for spaciai aggrigation of disease is developed. Meanings of interaction and standardization are syudied in depth and clarified from the point of view of causality. Estimators of summary hazard ratio are developed when there exist effect modification.[Statistical Methods for Clinical Data]. A set of new statistical methods are developed based on accumulated chi-squares. These methods are anticipated to replace the classical analysis of variance. Statistical testing procedures which adjust for the inbalance of background factors and to detect the equivalence or more than equivalence of two drugs is developed. A method is explored on the Meta Analysis so that it enables researchers to treat multicenter clinical trials.[Basic thory]. A new analysis of growth curves is explored by introducing linear models among parameters in growth-curve, algorithm of the method is developed and computer program is explored which can be used on parsonal computer. As is seen, for example, in the invited special lecture "Goodness of statistical estimator, from Pitagorian point of view" delivered at the Mathematical Society of Japan, basic theory of biostatistics is also very much advanced. Less

[毒理学资料分析]发表《毒理学数据统计分析》（Yoshimura, Ohashi）。这是第一本用日文写的这类书。还出版了《毒理学研究中的生物统计学》（Sakuma, Yanagawa， Yoshimura主编），这是第一届国际毒理学生物统计学会议的会议记录。提出了一种确定未观察到的不良效应水平的新方法。在啮齿动物微核试验的情况下，诱变试验数据的统计分析也进行了探讨。[流行病学方法论]。《人类癌症的生物统计学》（Yanagawa, Ohashi, Tango， Yanagimoto主编）是第四届日美人类癌症研究生物统计学会议论文集，同时出版的还有《医学统计学》（Tango）。这两份出版物对医学领域的研究人员产生了巨大的影响。广义的Mantel-Haenszel估计。更多关于2xJ表（J bbbb2）。提出了疾病空间聚集的统计检验方法。从因果关系的角度，深入研究了互动和标准化的含义。在存在效应修正的情况下，提出了综合风险比的估计方法。【临床资料统计方法】。提出了一套基于累积卡方的统计方法。这些方法有望取代经典的方差分析。统计检验程序，调整不平衡的背景因素和检测等效或超过等效的两种药物被开发。在Meta分析上探索了一种方法，使研究人员能够处理多中心临床试验。(基本从)。通过在生长曲线中引入参数间的线性模型，探索了一种新的生长曲线分析方法，给出了该方法的算法，并开发了可在个人计算机上使用的计算机程序。例如在日本数学会的特邀讲座《从Pitagorian的角度看统计估计器的良善》中可以看到，生物统计学的基础理论也非常先进。少