Biostatistics : Development of Bacic Theory and Ist Application

生物统计学:基础理论发展与应用

基本信息

批准号：
05302064
负责人：
YANAGAWA Takashi
金额：
$ 8万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

[Analysis of Toxicological Data]. "Statistical Analysis of Toxicological Data" is published (Yoshimura, Ohashi) . This is the first book of this kind written in Japanese. Also published is the "Biostatistics in the Study of Toxicology" (Sakuma, Yanagawa, Yoshimura eds.) which is the proceedings of the first International Biostatistics Conference in the Toxicology. A new method for the determination the of the no-observed-adverse-effect level is developed. Statistical analysis of data in mutageneity assays in the case of rodent micronucleus assay is also explored.[Methodologies in Epidemiology]. "Biostatistics in Human Cancer" (Yanagawa, Ohashi, Tango, Yanagimoto eds.) which is the proceedings of the fourth Japan-US Biostatistics Conference in the Study of Human Cancer is published : also published is the "Statistics for medical Science" (Tango). These two publications have given an inmense effect to researchers in the field of medical science. Mantel-Haenszel estimators are generalized … More for 2xJ table (J>2) . A statistical test for spaciai aggrigation of disease is developed. Meanings of interaction and standardization are syudied in depth and clarified from the point of view of causality. Estimators of summary hazard ratio are developed when there exist effect modification.[Statistical Methods for Clinical Data]. A set of new statistical methods are developed based on accumulated chi-squares. These methods are anticipated to replace the classical analysis of variance. Statistical testing procedures which adjust for the inbalance of background factors and to detect the equivalence or more than equivalence of two drugs is developed. A method is explored on the Meta Analysis so that it enables researchers to treat multicenter clinical trials.[Basic thory]. A new analysis of growth curves is explored by introducing linear models among parameters in growth-curve, algorithm of the method is developed and computer program is explored which can be used on parsonal computer. As is seen, for example, in the invited special lecture "Goodness of statistical estimator, from Pitagorian point of view" delivered at the Mathematical Society of Japan, basic theory of biostatistics is also very much advanced. Less

[毒理学分析]。发表了“毒理数据的统计分析”（Yoshimura，Ohashi）。这是用日语写的第一本书。还发表的是“毒理学研究中的生物统计学”（Sakuma，Yanagawa，Yoshimura eds。），这是毒理学第一次国际生物统计学会议的会议记录。开发了一种新方法来确定未观察到的不良效应水平。在啮齿动物微核测定法案的情况下，对诱变性测定中的数据进行了统计分析。[流行病学方法论]。 “人类癌症中的生物统计学”（Yanagawa，Ohashi，Tango，Yanagimoto eds。）是第四届Japan-US生物统计会议在人类癌症研究中的论文集：也出版了“医学科学统计学”（Tango）。这两个出版物对医学领域的研究人员产生了影响。壁炉架 - 哈森赛估计器已概括……更多的2xJ表（j> 2）。开发了疾病的统计检验。相互作用和标准化的含义从因果关系的角度进行了深入的深入和阐明。当存在效应修改时，就会开发出汇总危险比的估计值。[临床数据的统计方法]。一组新的统计方法是基于累积的卡方制定的。预计这些方法将取代经典的方差分析。为了调整背景因素的撞击并检测到两种药物的等效性的统计测试程序。在元分析上探索了一种方法，以使研究人员能够治疗多中心临床试验。[Basic Thory]。通过在生长曲线的参数之间引入线性模型，开发了该方法的算法，并探索了可以在Parsonal Computer上使用的计算机程序，从而探索了生长曲线的新分析。例如，例如，在受邀的特殊讲座中，“统计估计量的好处，从Pitagorian的角度来看”，在日本数学学会上传达了生物统计学的基本理论也非常先进。较少的