Dynamic Biostatistics : Modeling, Development of Methodology and Theory

动态生物统计学：建模、方法和理论的发展

• 批准号: 13308014
• 负责人: YANAGAWA Takashi
• 金额: $ 7.49万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13308014/
• 关键词: observational chaos; risk assessment; in vitro toxicity study; radiation carcinogenesis; Dioxin compounds; cDNA microarray data; QTL analysis; standardized mortality rate; 超過変動; 非線形モデリング; 分子進化速度; 父性解析; 遺伝毒性試験; 発がん過程の数理モデル化; 2次制約付き相関係数最大化問題

1. Developed a method of estimating Lyapunov exponent to detect chaos in observational data and proved its consistency. 2. Developed a method of risk assessment for complex data and applied it for studying joint effects of environmental contaminants on thyroid hormone status of breast fed infants in Japan. 3. Developed a new procedure of data analysis for the mouse lymphoma assay and the cell transformation assay in vitro toxicity studies. 4. Developed a technique for constructing pattern recognition machine based on radial basis function network that can be easily applied to analyze the high-dimensional continuous and discontinuous data. 5. Developed a mathematical model of radiation carcinogenesis based on the genomic instability hypothesis. 6. Based on a generalized phamacokinetic theory that accounts for accumulated measurements of contaminants with rates of their inflow into and elimination out of a body, a random effects model for concentration of Dioxin compounds in peripheral blood of residents is developed. 7. Developed a mathematical model of cDNA microarray data for gene expressions, and proposed an efficient method for normalization of the data. ( applied two patents on the model and method.) 8. Extended our hierarchical model of change in rate of molecular evolution to accommodate multiple loci and proposed a procedure to test correlated evolution between loci. 9. Developed a genetic algorithm to do QTL analysis for outbreeding populations, taking uncertainty of linkage phase into account. 10. Modified weights in marginal structural models to estimate the standardized mortality ratio nonparametrically and showed general relationship between standardization methods and marginal structural models.

1。开发了一种估算Lyapunov指数来检测观察数据中混乱的方法，并证明了其一致性。 2。开发了一种用于复杂数据的风险评估方法，并将其应用于研究日本甲状腺激素状态的环境污染物对甲状腺激素状态的关节作用。 3。开发了针对小鼠淋巴瘤测定法和体外毒性研究细胞转化测定的新的数据分析程序。 4。开发了一种基于径向基础函数网络构建模式识别机的技术，可以轻松地应用于分析高维连续和不连续数据的技术。 5。基于基因组不稳定性假设开发了辐射癌变的数学模型。 6。基于一种广义的Phamacokinetic理论，该理论是对污染物的积累测量，其流入率从人体中消除并消除了，因此开发了居民外周血中二恶英化合物浓度的随机效应模型。 7。开发了一种用于基因表达的cDNA微阵列数据的数学模型，并提出了一种有效的数据标准化方法。 （在模型和方法上应用了两项专利。）8。扩展了我们分子进化速率变化的分层模型，以适应多个基因座，并提出了一种测试基因座之间相关演变的程序。 9。开发了一种遗传算法，以考虑链接阶段的不确定性进行QTL分析。 10。边缘结构模型中的修改权重以非参数估算标准化死亡率比率，并显示标准化方法与边缘结构模型之间的一般关系。

项目成果

Kawaguchi, A.: "Estimating correlation dimension in chaotic time series"Bulletin of Informatics and Cybernetics. (印刷中). (2002)

Kawaguchi, A.：“估计混沌时间序列中的相关维数”信息学和控制论公报（2002 年出版）。

安道知寛: "動径基底関数ネットワークに基づく非線形回帰モデルとその推定"応用統計学. 30. 19-35 (2001)

Tomohiro Ando：“基于径向基函数网络的非线性回归模型及其估计”应用统计30. 19-35 (2001)。

Hashimoto, A.: "Correlation maximization under linear and quadratic constraints"Bulletin of the International Statistical Institute, 53rd Session. 117-118 (2001)

Hashimoto, A.：“线性和二次约束下的相关性最大化”国际统计研究所公报，第 53 届会议。

Yamaguchi, T.: "Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator"Gene Therapy. (印刷中).

Yamaguchi, T.：“BimS（一种仅 BH3 的细胞死亡激活剂）增强胸苷激酶介导的恶性神经胶质瘤杀伤作用”基因治疗（正在出版）。

Ichikawa, M. and Konishi, S.: "Asymptotic expansions and bootstrap approximations in factor analysis"Journal of Multivariate Analysis. 81. 47-66 (2002)

Ichikawa, M. 和 Konishi, S.：“因子分析中的渐近展开和自举近似”多元分析杂志。