Dynamic Biostatistics : Modeling, Development of Methodology and Theory

动态生物统计学：建模、方法和理论的发展

• 批准号: 13308014
• 负责人: YANAGAWA Takashi
• 金额: $ 7.49万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13308014/
• 关键词: observational chaos; risk assessment; in vitro toxicity study; radiation carcinogenesis; Dioxin compounds; cDNA microarray data; QTL analysis; standardized mortality rate; 超過変動; 非線形モデリング; 分子進化速度; 父性解析; 遺伝毒性試験; 発がん過程の数理モデル化; 2次制約付き相関係数最大化問題

1. Developed a method of estimating Lyapunov exponent to detect chaos in observational data and proved its consistency. 2. Developed a method of risk assessment for complex data and applied it for studying joint effects of environmental contaminants on thyroid hormone status of breast fed infants in Japan. 3. Developed a new procedure of data analysis for the mouse lymphoma assay and the cell transformation assay in vitro toxicity studies. 4. Developed a technique for constructing pattern recognition machine based on radial basis function network that can be easily applied to analyze the high-dimensional continuous and discontinuous data. 5. Developed a mathematical model of radiation carcinogenesis based on the genomic instability hypothesis. 6. Based on a generalized phamacokinetic theory that accounts for accumulated measurements of contaminants with rates of their inflow into and elimination out of a body, a random effects model for concentration of Dioxin compounds in peripheral blood of residents is developed. 7. Developed a mathematical model of cDNA microarray data for gene expressions, and proposed an efficient method for normalization of the data. ( applied two patents on the model and method.) 8. Extended our hierarchical model of change in rate of molecular evolution to accommodate multiple loci and proposed a procedure to test correlated evolution between loci. 9. Developed a genetic algorithm to do QTL analysis for outbreeding populations, taking uncertainty of linkage phase into account. 10. Modified weights in marginal structural models to estimate the standardized mortality ratio nonparametrically and showed general relationship between standardization methods and marginal structural models.

1. 提出了一种估计李雅普诺夫指数的方法来检测观测数据中的混沌现象，并证明了其一致性。2. 开发了一种复杂数据风险评估方法，并应用于日本环境污染物对母乳喂养婴儿甲状腺激素状况的联合影响研究。开发了一种新的数据分析程序，用于小鼠淋巴瘤试验和体外毒性研究中的细胞转化试验。4. 提出了一种基于径向基函数网络的模式识别机的构造方法，该方法可以方便地分析高维连续和不连续数据。5. 基于基因组不稳定性假说，建立了辐射致癌的数学模型。6. 基于一个广义的药代动力学理论，该理论考虑了污染物的流入和排出速率的累积测量，建立了居民外周血中二恶英化合物浓度的随机效应模型。7. 建立了基因表达的cDNA微阵列数据的数学模型，提出了一种有效的数据归一化方法。（对模型和方法申请了两项专利。）8. 扩展了分子进化速率变化的层次模型以适应多个位点，并提出了一种检测位点间相关进化的方法。9. 提出了一种考虑连锁阶段不确定性的遗传算法，对远交群体进行QTL分析。10. 修正了边际结构模型的权重，非参数地估计了标准化死亡率，并揭示了标准化方法与边际结构模型之间的一般关系。

项目成果

安道知寛: "動径基底関数ネットワークに基づく非線形回帰モデルとその推定"応用統計学. 30. 19-35 (2001)

Tomohiro Ando：“基于径向基函数网络的非线性回归模型及其估计”应用统计30. 19-35 (2001)。

Yanagawa, T.: "Assessing the joint effects of chlorinated dioxin, some pesticides and polychlorinated byphenyles on thyroid hormone status in Japanese breast fed infants"Environmetrics. (印刷中). (2003)

Yanakawa, T.：“评估氯化二恶英、某些农药和多氯联苯对日本母乳喂养婴儿甲状腺激素状态的联合影响”（出版中）。

寒水孝司: "「臨床試験のための統計的原則」における交互作用の扱い方についての考察"応用統計学. 30. 1-18 (2002)

Takashi Kansui：“关于如何处理‘临床试验统计原则’中交互的考虑”应用统计学，30. 1-18 (2002)。

Ohashi Y.: "Habitual Intake of Lactic Acid Bacteria and Risk Reduction of Bladder Cancer"Urologia Internationalis. 68. 273-280 (2002)

Ohashi Y.：“习惯性摄入乳酸菌与降低膀胱癌风险”Urologia Internationalis。

Yanagawa, T., Kobayashi, Y., and Nagayama, J.: "Assessing the joint effects of chlorinated dioxin, some pesticides and polychlorinated byphenyles on thyroid hormone status in Japanese breast fed infants"Environmetries. in press. (2003)

Yanakawa, T.、Kobayashi, Y. 和 Nagayama, J.：“评估氯化二恶英、某些农药和多氯联苯对日本母乳喂养婴儿甲状腺激素状态的联合影响”。