Development and Application of Graphical Modeling techniques for Assesshrg the Joint Risks of Contaminants
评估污染物联合风险的图形建模技术的开发和应用
基本信息
- 批准号:15300093
- 负责人:
- 金额:$ 4.61万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The graphical modeling techniques which have been proposed for the analysis of complex causal relationship are developed under the assumption of multivariate normal distribution. Thus they are limited for modeling only linear cause-effect relationships. 'lb remove this restriction we developed in this project graphical modeling techniques based on rank correlation matrix. The method was applied for studying joint risks of environmental contaminants such as Dioxin, PCB and pesticides measuring the amount of these chemicals in breast milks of 120 women and also measuring the thyroid and immune hormone status of infants from those mothers. It was discovered by the method that the odds ratios of thyroid function and Dioxin was 1.65 (p=0.29), but was 7.15 (p=0.02) when adjusted for PCB.We further developed a method of graphical modeling technique that used latent structure models, and also explored the method that may deal with time series data.Theoretical studies were conducted to develop those methods mentioned above ; namely(i)Developed estimation and testing method for comparing two negative binomial distributions by adjusting for confounding variables by stratification.(ii)Developed a method of nonparametric imputation.(iii) Developed a theory to extract information from high dimensional data by modeling the data using various base functions ; developed a Bayes Information criteria to select the models; applied it to not only the graphical modeling but also other statistical methods such as disiminant analysis for DNA data and others.(iv)Developed a theory of graphical modeling for repeated measurements data in one to K multiple comparison setting and developed an approximate confidence intervals for the parameters involved.(v)Developed theory for estimating unknown drift parameter and diffusion parameter of the diffusion process with small diffusion and proved their consisitency and asymptotic normality.
复杂因果关系的图形化建模技术是在多元正态分布的假设下发展起来的。因此,它们仅限于对线性因果关系进行建模。“为了消除这一限制,我们在这个项目中开发了基于等级相关矩阵的图形建模技术。该方法被用于研究二恶英、多氯联苯和杀虫剂等环境污染物的联合风险,测量了120名妇女母乳中这些化学物质的含量,并测量了这些母亲所生婴儿的甲状腺和免疫激素状况。该方法发现甲状腺功能与二恶英的比值比为1.65 (p=0.29),校正PCB后为7.15 (p=0.02)。我们进一步开发了一种使用潜在结构模型的图形化建模技术,并探索了处理时间序列数据的方法。对上述方法进行了理论研究;即(i)通过分层调整混杂变量,制定了比较两个负二项分布的估计和检验方法。发展了一种非参数归算方法。发展一种理论,利用各种基函数对数据建模,从高维数据中提取资料;建立了贝叶斯信息准则来选择模型;不仅将其应用于图形建模,还将其应用于其他统计方法,如DNA数据的判别分析等。为1至K倍比较设置中的重复测量数据制定了图形建模理论,并为所涉及的参数制定了近似置信区间。(v)提出了估计小扩散扩散过程的未知漂移参数和扩散参数的理论,并证明了它们的一致性和渐近正态性。
项目成果
期刊论文数量(239)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Small-diffusion asymptotics for discretely sampled stochastic differential equations
- DOI:10.3150/bj/1072215200
- 发表时间:2003-12
- 期刊:
- 影响因子:1.5
- 作者:Michael Sørensen;Masayuki Uchida
- 通讯作者:Michael Sørensen;Masayuki Uchida
正則化局所尤度法に基づく非線形回帰モデリング
基于正则化局部似然法的非线性回归建模
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:S.Ichioka S;Kudo;M.Shibata;J.Ando;N.Sekiya;T.Nakatsuka;野中 美佑
- 通讯作者:野中 美佑
Multiple comparisons in nonlinear repeated measurements
非线性重复测量中的多重比较
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Hyakutake;H.
- 通讯作者:H.
Effects of organochiorine compounds such as pesticides, PCBs and dioxins on thyroid hormone
农药、多氯联苯和二恶英等有机氯化合物对甲状腺激素的影响
- DOI:
- 发表时间:2002
- 期刊:
- 影响因子:0
- 作者:Nagayama J.
- 通讯作者:Nagayama J.
岸 玲子: "職業・環境がんの疾学"篠原出版新社. 151 (2004)
Reiko Kishi:“职业和环境癌症疾病”筱原出版社 151(2004)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
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YANAGAWA Takashi的其他文献
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{{ truncateString('YANAGAWA Takashi', 18)}}的其他基金
Analysis of interaction between autocrine motility factor and molecules related to bone formation in osteosarcoma cells.
骨肉瘤细胞自分泌运动因子与骨形成相关分子相互作用的分析。
- 批准号:
20791026 - 财政年份:2008
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of functional ANOVA models for multi-state survival data and its applications
多状态生存数据函数方差分析模型的开发及其应用
- 批准号:
20300099 - 财政年份:2008
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Roles and Efficiency of Vertical Separation in Railway Industry
垂直分离在铁路行业中的作用和效率
- 批准号:
20530198 - 财政年份:2008
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development and application of semi-parametric survival analysis for time dependent non-linear prognostic factors
时间依赖性非线性预后因素半参数生存分析的开发和应用
- 批准号:
17300091 - 财政年份:2005
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Vertical Integration and Separation of Firms for Regulation and Competition
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- 批准号:
17530177 - 财政年份:2005
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Dynamic Biostatistics : Modeling, Development of Methodology and Theory
动态生物统计学:建模、方法和理论的发展
- 批准号:
13308014 - 财政年份:2001
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Economic Policy of Horizontal Competition Restraint
限制同业竞争的经济政策
- 批准号:
13630060 - 财政年份:2001
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Biostatistics : Development of Bacic Theory and Ist Application
生物统计学:基础理论发展与应用
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05302064 - 财政年份:1993
- 资助金额:
$ 4.61万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
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