生体肝移植における移植肝容積量と自己肝温存同所性生体部分肝移植の開発に関する研究

活体肝移植移植肝体积研究及自体保肝原位部分肝移植的进展

• 批准号: 06404046
• 负责人: TANAKA Koichi
• 金额: $ 10.24万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06404046/
• 关键词: living related liver transplanttation; auxiliary partial orthotopic liver transplantation; portal vein; canine model; liver degeneration; liver volume; clinical; 移植肝サイズマッチング; 肝移植; 自己肝温存同所性部分肝移植; 肝組織酸素化; 門脈血流量; 生体肝移植分肝機能

We studied the relation between outcomes and graft volume in our living related liver transplantation series and found that the lower limit of the ratio of graft volume to the recipient body weight was 0.8%. In the setting of living related liver transplantation for children using partial liver grafts of parents, the volume of the partial grafts is usually enough for children. In the setting of adult recipients, however, the ratio is often lower than 0.8%, even though we use left lobe grafts including the middle hepatic vein. To solve this problem, we developed auxiliary partial orthotopic liver transplantation, in which the lateral segments or the left lobe of the native liver was removed from a recipient, a partial graft was trnasplanted, and the preserved native liver helped the graft liver until the graft gro** enough. In our experiment using a canine model, we focused on competition between the native liver and the graft liver regarding portal flow and studied the effects of diversion of the portal flow of the native liver. Our results demonstrated that the entire portal flow of the native liver can be diverted safely to the graft. Based on this result, we applied this technique to clinical transplantation and solved the problem of graft size mismatch in adult living related liver transplantation.

我们研究了活体相关肝移植的预后与移植物体积的关系，发现移植物体积与受体体重之比的下限为0.8%。在采用父母部分肝移植进行儿童活体亲缘肝移植的情况下，部分肝移植的体积通常足以满足儿童的需要。然而，在成人受体的情况下，即使我们使用包括肝中静脉在内的左叶移植物，这一比例也往往低于0.8%。为了解决这个问题，我们开发了辅助部分原位肝移植，即从受者身上切除天然肝脏的外侧节段或左叶，移植部分移植物，保留的天然肝脏帮助移植物生长，直到移植物生长足够。在犬模型实验中，我们关注了原生肝和移植肝在门静脉流动方面的竞争，并研究了原生肝门静脉流动转移的影响。我们的结果表明，整个天然肝脏的门静脉流动可以安全地转移到移植物上。在此基础上，我们将该技术应用于临床移植，解决了成人活体肝移植中移植物大小不匹配的问题。

项目成果

T.Morimoto,: "Analysis of functional abnormalities uncovered during preoperative evaluation of donor canditates for living-related liver transplantation" Clinical Transplantation. 9. 60-64 (1995)

T.Morimoto，：“活体相关肝移植供体候选者术前评估中发现的功能异常分析”临床移植。

M.Fujimoto,: "Evaluation of portal hemodynamics Doppler ultrasound in living related donor liver transplantation in child Implications for ligation of spontaneous portosystemic collateral pathways" Transplantation Proceedings. 27. 1174-1176 (1995)

M.Fujimoto，：“儿童活体相关供体肝移植中门静脉血流动力学多普勒超声的评估对自发门体侧支通路结扎的影响”移植论文集。

H.Terajima: "Timing of transplantation and donor selection in living related liver transplantation for fulminant Wilson's disease" Transplantation Proceedings. 27(1). 1177-1178 (1995)

H.Terajima：“暴发性威尔逊病活体相关肝移植中的移植时机和供者选择”移植论文集。

T Morimoto: "Donor safety in living related liver transplantation." JAMA. 27(1). (1995)

T Morimoto：“活体相关肝移植中供体的安全性。”

K.Tanaka: "Living-related liver transplantation for fulminant hepatic failure in children" Transpl Int.7 (Suppl). S108-S110 (1994)

K.Tanaka：“儿童暴发性肝衰竭的活体相关肝移植”Transpl Int.7（增刊）。