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Development of percutaneous right heart assist system by using axial flow pump

轴流泵经皮右心辅助系统的研制

基本信息

批准号：
06557074
负责人：
NAKATANI Takeshi
金额：
$ 4.99万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557074/
关键词：
axial flow pump right heart assist percutaneous venous insertion

项目摘要

Right ventricular (RV) function is a limiting facotr to maintain systemic circulation for circulatory assist. There is, however, no easy way to institute RV assist, such as an intraarterial axial flow pump (Hemopump) for left heart assist. In this reseatch, new RV assist system by intravenous use of an axial flow pump was developed and its feasibility and hemodynamic effect was examined. A pump system was developed with an outflow cannula and an impeller which were newly designed for intravenousm insertion with a driving system of Hemopump. The pump system characteristics using goat blood of hematocrit at 26% indicated that maximum flow at a pressure differential against 40 mmHg is 3.2 1/min at a pump speed of 28,000 rpm. The pump was tested in adult goats by intravenous insertion through a 14 mm low porosity graft anastomosed to the infrarenal inferior vena cava. The pump was advances unitil the tip of cannula was positioned at the main pulmonary artery by using a balloon catheter duidance under fluoroscopy. In animal experiments, pump insertion was performaed without complications. In chronic studies using adult goats for up to 48 hours, levels of plasma hemoglobin and platelet counts were acceptable and no prominent daamage was foung in heart tissues. Based on this study, an axial flow pump positioned in the right heart introduced through an intravenous approach is practicable and affords adequate assist for right heart.

右心室（RV）功能是维持循环辅助系统体循环的限制因素。然而，没有简单的方法来建立RV辅助，例如用于左心辅助的动脉内轴流泵（Hemopump）。本研究开发了一种新的静脉用轴流泵辅助右心室（RV）的系统，并对其可行性和血流动力学效果进行了研究。本文介绍了一种新型的血液泵系统，该系统包括一个流出套管和一个叶轮。使用血细胞比容为26%的山羊血的泵系统特性表明，在28，000 rpm的泵速下，压差为40 mmHg时的最大流量为3.2 l/min。在成年山羊中，通过静脉内插入14 mm低孔隙度移植物（与肾下下腔静脉相连）对泵进行了测试。在X线透视下，使用球囊导管引导，推进泵，直至插管头端定位在主肺动脉。在动物实验中，泵插入没有并发症。在使用成年山羊长达48小时的慢性研究中，血浆血红蛋白和血小板计数水平是可接受的，心脏组织中没有明显的损伤。基于本研究，通过静脉途径引入位于右心内的轴流泵是可行的，并为右心提供足够的辅助。