Effect of radiation to human health by Chernobyl accident

切尔诺贝利事故辐射对人体健康的影响

• 批准号: 07044269
• 负责人: IMAMURA Nobutaka
• 金额: $ 2.3万
• 依托单位: Research Institute for Radiation Biology and Medicine, Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044269/
• 关键词: Acute myelogenous leukemia; acute lymphoblastic; chronic myelogenous; chronic lymphocytic; myelodysplastic syndrome; liquidator (clean up workers); Kiev; malignant hematological disorders

In Ukrainian Center for Radiation Medicine in Kiev (Director Bebeshko), Prof.Klimenko has been examining 120,000 liquidators in every year. They were set to be lower than 25 mSv irradiation, however, it was suggested that some of them exposd more than 100 mSv irradiation. I co-investigated those liquidators and found 141 patients with leukemia until 1993. Among them, 86 patients were diagnosed as acute leukemia.During from 1993 to 1995, we found 42 patients with hematological malignancies. They were 16 cases of acute myelogenous leukemia, which were classified as AML M1 (2 cases), AML M2 (2 cases), AML M3 (2 cases), AML M4 (5 cases) according to FAB classification, AML M5 (4 cases), respectively. We found 2 cases of acute lymphoblastic leukemia (ALL L2 ; FAB). We found 8 patients with chronic myelogenous leukemia and 8 patients with chronic lymphocytic leukemia. We analyzed 2 cases of AML and found that deletion of exon 5 and exon 6 of p53 suppressor oncogene.On the bases of these finding, it is suggested that the incidence of leukemia among liquidators is increasing tendency, recently.

在基辅的乌克兰放射医学中心（主任别别什科），克利缅科教授每年都在检查12万名清算人。它们被设定为低于25 mSv辐照，然而，有人建议其中一些超过100 mSv辐照。我参与调查了这些清理者，直到1993年，我发现了141名白血病患者。其中急性白血病86例，1993 ~ 1995年共发现恶性血液病42例。急性髓系白血病16例，按FAB分型，M1 2例，M2 2例，M3 2例，M4 5例，M5 4例。我们发现2例急性淋巴细胞白血病（ALL L2 ; FAB）。发现慢性粒细胞白血病8例，慢性淋巴细胞白血病8例。本文分析了2例急性髓细胞白血病（AML）患者，发现p53抑癌基因第5、6外显子缺失，提示近年来清算者白血病的发病率有增高的趋势。

项目成果

Imamura N.: "Expression and point mutation of p53 suppressor oncogene in patients with myelodysplastic syndrome among atomic-bomb survivors and victims of the Chernobyl accident." Experimental Oncology. 18. 333-337 (1996)

Imamura N.：“原子弹幸存者和切尔诺贝利事故受害者中骨髓增生异常综合征患者 p53 抑癌基因的表达和点突变。”

今村展隆: "Natural killer細胞白血病の病態と治療 -第三リンパ球亜群由来の新臨床疾病概念-" 社保医誌. 35. 117-121 (1995)

Nobutaka Imamura：“自然杀伤细胞白血病的病理学和治疗 - 源自第三淋巴细胞亚群的新临床疾病概念”《社会保险杂志》35. 117-121 (1995)。

今村展隆: "被爆者及び非被爆者骨髄異形成症候群におけるp53癌抑制遺伝子の点突然変異" 広島医学. 49. 336-339 (1996)

Nobutaka Imamura：“原子弹幸存者和非原子弹幸存者的骨髓增生异常综合征中 p53 肿瘤抑制基因的点突变”广岛医学 49. 336-339 (1996)。

HANGAICHI A.: "Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle MTS1/p161^<NK4A> CDKN2, MTS2/p15^<1NK4B> p53, and Rb genes in primary lymphoid malignances." Blood. 87. 4949-4958 (1996)

HANGAICHI A.：“原发性淋巴恶性肿瘤中参与细胞周期 MTS1/p161^<NK4A> CDKN2、MTS2/p15^<1NK4B> p53 和 Rb 基因负调节的多个肿瘤抑制基因的失活。”

阿部和弘: "骨髄異形成症候群患者の重複癌の検討" 広島医学. 48. 1093-1095 (1995)

Kazuhiro Abe：“骨髓增生异常综合征患者的多种癌症检查”广岛医学 48. 1093-1095 (1995)