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Hematological malignancies among Chernobyl Liquidators

切尔诺贝利清理者中的血液恶性肿瘤

基本信息

批准号：
09044311
负责人：
IMAMURA Nobutaka
金额：
$ 3.14万
依托单位：
HIROSSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

We had found high incidence of acute leukemias in liquidators in Vitebsk region (1,423,000 population) after Chernobyl accident. In Ukrainian Center of Radiation Medicine in Kiev (Director Bebeshko), Prof. Klimenko has been examining 120,000 liquidators in every year. They were set to be lower than 25 mSv irradiation dose, however, it was speculated that some of them were exposed more than 100 mSv . I co-investigated to diagnose those liquidators and found 141 patients with leukemia until 1993. Among them, 86 patients were diagnosed as acute leukemia. During from 1993 to 1995, we found 42 patients with hematological malignancies. They were 16 cases of acute myelogenous leukemia, which were classified as AML M1 (2 cases), AML M2 (2 cases), AML M3 (2 cases), AML M4 (5 cases), AML M5 (4 cases) according to FAB classification, respectively. We found 2 cases of acute lymphoblastic leukemia (ALL L2: FAB). We also found 8 patients with chronic myelogenous leukemia and 8 patients with chronic lymphocytic leukemia. We analysed DNA from cases of AML and found that deletion of exon 5 and exon 6 of p53 suppressor oncogene due to p53 gene mutation.We investigated the incidence of leukemias and malignant lymphomas among liquidators living in the regions, Dnepropetrovsk (21,906 person), Dnetsk (26,506), and Charkov (28,314). By sex-matched statistical analysis, we found that the relative risk was 0.02 and 0.05, for liquidators of 1986 and 1987, respectively.The relative risk for malignant lymphomas was 0.35 and 0.75, for 1986 and 1987 liquidators, respectively. On the bases of these findings, we suggest that the development of hematological malignancies is dependent on radiation dose. It is suggested that the incidence of leukemia including myelodysplastic syndrome among liquidators is increasing tendency, recently.

我们发现切尔诺贝利事故后维捷布斯克地区（1,423,000 人口）的清算人急性白血病发病率很高。在位于基辅的乌克兰放射医学中心（主任Bebeshko），Klimenko 教授每年都会检查 120,000 名清算人。它们的照射剂量被设置为低于25毫希沃特，但据推测其中一些辐射剂量超过了100毫希沃特。我和清算人共同调查诊断，到1993年为止，发现了141名白血病患者，其中86名患者被诊断为急性白血病。 1993年至1995年间，我们发现了42名血液系统恶性肿瘤患者。急性髓系白血病16例，按FAB分型分别为AML M1（2例）、AML M2（2例）、AML M3（2例）、AML M4（5例）、AML M5（4例）。我们发现 2 例急性淋巴细胞白血病（ALL L2：FAB）。我们还发现了8名慢性粒细胞白血病患者和8名慢性淋巴细胞白血病患者。我们分析了AML病例的DNA，发现由于p53基因突变，p53抑癌基因的外显子5和外显子6被删除。我们调查了居住在第聂伯罗彼得罗夫斯克（21,906人）、第涅茨克（26,506人）和查尔科夫（28,314人）地区的清算人中白血病和恶性淋巴瘤的发病率。通过性别匹配统计分析，我们发现1986年和1987年清算人的相对风险分别为0.02和0.05。1986年和1987年清算人的恶性淋巴瘤相对风险分别为0.35和0.75。根据这些发现，我们认为血液恶性肿瘤的发生依赖于辐射剂量。提示近年来清算人中包括骨髓增生异常综合征在内的白血病发病率呈上升趋势。