The effects of UVA irradiation on human neutrophil function
The effects of UVA irradiation on human neutrophil function
批准号:
07407011
负责人:
SUGAWARA Kazuo
金额:
$10.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1997
中文摘要
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英文摘要
We investigated the in vitro effects of ultraviolet light A (UVA) irradiation on human neutrophil function. For measurements of reactive oxygen species (ROS) and serum opsonic activity, chemiluminescence method was used. Chemotactic activity was determined by Boyden technique. UVA irradiation at low dose of UVA (0.2-0.4 J/cm^2) did not affect the generation of OC1^-, whereas high dose of UVA (0.6-1.0 J/cm^2) suppressed its production by inactivating the signalling cascade which induce ROS on the membrane surface of neutrophils. No significant difference was observed in the chemotactic activity. The serum opsonic activity was increased by UVA irradiation. These results suggest that low dose of UVA does not impair the neutrophil-related immune system, and that higher dose of UVA is required for UVA phototherapy.
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作者:
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通讯作者:
Shiraishi M, et al.: "Diurnal variation in neutrophil function." Environ Health Prev Med. 1. 65-70 (1996)
Shiraishi M 等人:“中性粒细胞功能的昼夜变化。”
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