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The effects of UVA irradiation on human neutrophil function

The effects of UVA irradiation on human neutrophil function
UVA照射对人体中性粒细胞功能的影响
批准号:
07407011
负责人:
SUGAWARA Kazuo
金额:
$10.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1997

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中文摘要
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英文摘要
We investigated the in vitro effects of ultraviolet light A (UVA) irradiation on human neutrophil function. For measurements of reactive oxygen species (ROS) and serum opsonic activity, chemiluminescence method was used. Chemotactic activity was determined by Boyden technique. UVA irradiation at low dose of UVA (0.2-0.4 J/cm^2) did not affect the generation of OC1^-, whereas high dose of UVA (0.6-1.0 J/cm^2) suppressed its production by inactivating the signalling cascade which induce ROS on the membrane surface of neutrophils. No significant difference was observed in the chemotactic activity. The serum opsonic activity was increased by UVA irradiation. These results suggest that low dose of UVA does not impair the neutrophil-related immune system, and that higher dose of UVA is required for UVA phototherapy.
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通讯作者:
Shiraishi M,Suzuki K,Satoh H,Nakaji S,Sugawara K,Abe T,Kikuchi T.: "Diurnal variation in neutrophil function" Environ Health Prev Med. 1. 65-70 (1996)
白石 M、铃木 K、佐藤 H、中路 S、菅原 K、阿部 T、菊池 T.:“中性粒细胞功能的昼夜变化”Environ Health Prev Med。
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通讯作者:
Suzuki K,Sato H,Kikuchi T,Abe T,Nakaji S,Sugawara K,Totsuka M,Sato K,Yamaya K.: "Capacity of circulating neutrophil to produce reactive oxygen species after exhaustive exercise." J Appl Physiol. 81 (3). 1213-1222 (1996)
Suzuki K、Sato H、Kikuchi T、Abe T、Nakaji S、Sukawara K、Totsuka M、Sato K、Yamaya K.:“力竭运动后循环中性粒细胞产生活性氧的能力。”
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通讯作者:
Liu Q,Sugita N,Suzuki K,Koie T,Nakaji S,Sugawara K.: "Effects of natural 9-CIS and synthetic all trans beta-carotenes on the chemiluminescenceresponses of human neutrophils." J Phys Fit Nutr Immunol. 7. 57-63 (1997)
Liu Q、Sugita N、Suzuki K、Koie T、Nakaji S、Sukawara K.:“天然 9-CIS 和合成全反式 β-胡萝卜素对人类中性粒细胞化学发光反应的影响。”
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21
    Community Structure analysis of arbuscular mycorrhizalfungi in grassland ecosystem using DNA analysis
    • 批准号:
      14360157
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.37万
    • 财政年份:
      2002
    • 负责人:
      SUGAWARA Kazuo
    • 依托单位:
    Antioxidant activities of natural 9-cis β-carotene of Donliella bardawil on human neutrophil ROS production
    • 批准号:
      11357004
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $9.91万
    • 财政年份:
      1999
    • 负责人:
      SUGAWARA Kazuo
    • 依托单位:
    Analyses of stress responses and thier adaptation mechanisms of the body in special references to formation and removal systems of reactive oxigen species.
    • 批准号:
      10307009
    • 项目类别:
      Grant-in-Aid for Scientific Research (A).
    • 资助金额:
      $16.38万
    • 财政年份:
      1998
    • 负责人:
      SUGAWARA Kazuo
    • 依托单位:
    Nitrogen flow in the legume forage plants-ruminant production system.
    • 批准号:
      08660325
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.34万
    • 财政年份:
      1996
    • 负责人:
      SUGAWARA Kazuo
    • 依托单位: