权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

聴覚の発達段階における内耳電気刺激の影響と可塑性

听觉发育阶段内耳电刺激的影响和可塑性

基本信息

批准号：
07457400
负责人：
KUBO Takeshi
金额：
$ 2.75万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457400/
关键词：
auditory plasticity basic FGF NCAM-H regeneration of hair cell neural network gicerin cochlear implant congenital deafness 誘導因子人工内耳動物モデル聴覚可塑性鳥反発因子

项目摘要

Auditory hair cell regeneration after acoustic trauma and development of neural network were studied in chick for understanding auditory plasticity mechanism. It was found that the supporting cells devided and deferentiated into new hair cells immediately after the destruction of hair cells caused by the intense noise exposure (Umemoto et al, Cell & Tissue Res 1995). The basic FGF was related to the proliferation of the supporting cells. The role of cell adhesion molecules such as NCAM-H and gicerine on the process of auditory nerual development were then studied in the chick. It was suggested that NCAM-H specifically regurated the afferent nerve fiber's growth and synaptogenesis with hair cells during inner ear development (Kajikawa et al, Hearing Res 1997). The gicerin was associated with cell proliferation in the auditory epithelium, and playd a role in neurite extension of the acousitc ganglion cells in conjunction with neurite outgrowth factor (Kajikawa et al, J Neurocytol 1997). Auditory plasticity was also studied in human subjects who received the cochlear implant. Congenitally deafned or pre-lingualistically deafned children demonstrated an excellent auditory ability after two to three years auditory-verbal habilitation (Kubo and Iwaki, Pediatric Otolaryngol 1997).

为了了解听觉可塑性的机制，对雏鸡听觉损伤后的毛细胞再生和神经网络的发育进行了研究。研究发现，在强噪声暴露造成毛细胞破坏后，支持细胞立即分裂并分化为新的毛细胞(Uemoto等人，细胞与组织资源1995)。碱性成纤维细胞生长因子与支持细胞的增殖有关。然后研究了NCAM-H和gicerine等细胞黏附分子在雏鸡听神经发育过程中的作用。有人提出，在内耳发育过程中，NCAM-H特异性地恢复了传入神经纤维的生长和与毛细胞的突触发生(Kajikawa等人，听力资源1997)。Gicerin与听觉上皮细胞的增殖有关，并与轴突生长因子一起在听神经节细胞的轴突延伸中发挥作用(Kajikawa等，J Neurocell l 1997)。还研究了接受人工耳蜗术的受试者的听觉可塑性。先天聋或先天语言聋的儿童在两到三年的听觉-语言康复后表现出极好的听觉能力(Kubo和Iwaki，1997年儿科耳鼻喉科)。