Investigation for brain mechanisms of tinnitus using positron emission tomography(PET).

使用正电子发射断层扫描（PET）研究耳鸣的脑机制。

• 批准号: 15390518
• 负责人: KUBO Takeshi
• 金额: $ 2.88万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390518/
• 关键词: Cochlear implant; tinnitus; PET; H_2O_<15>; residual inhibition; ^<11>C-flumazenil; 盲聾患者

Residual inhibition is a transient suppression of tinnitus after auditory stimulation has stopped. We used positron emission tomography to study brain regions underlying residual inhibition in three tinnitus patients with cochlear implants and six normal hearing controls. Regional cerebral blood flow was measured and compared under two conditions : with tinnitus and during the residual inhibition of tinnitus. The right anterior middle and superior temporal gyri (Brodmann areas 21 and 38) were activated during residual inhibition, while the right cerebellum was activated during tinnitus perception in the tinnitus patients. No significant activation was observed in the normal controls. Our results suggest that tinnitus and residual inhibition are related to cortical networks of auditory higher-order processing, memory and attention.

残留抑制是听觉刺激停止后对耳鸣的短暂抑制。我们使用正电子发射断层扫描研究三个耳鸣患者的人工耳蜗植入和六个正常的听力控制的残留抑制的大脑区域。局部脑血流量的测量和比较两种情况下：耳鸣和耳鸣残留抑制期间。耳鸣患者在残余抑制时激活右侧前中回和上级颞回（Brodmann区21和38），而在耳鸣感知时激活右侧小脑。在正常对照中未观察到显著激活。我们的研究结果表明，耳鸣和残余抑制与听觉高阶处理，记忆和注意的皮层网络。

项目成果

N1m recovery from decline after exposure to noise with strong spectral contrasts

• DOI: 10.1016/j.heares.2004.04.017
• 发表时间: 2004-10-01
• 期刊: HEARING RESEARCH
• 影响因子: 2.8
• 作者: Okamoto, H;Ross, B;Pantev, C
• 通讯作者: Pantev, C

Osaki, Y., et al.: "Cortical processing of tactile language in a postlingually deaf-blind subject"Neuroreport. 15(2). 287-291 (2004)

Osaki, Y. 等人：“语后聋盲受试者触觉语言的皮层处理”神经报告。

Cortical processing of tactile language in a postlingually deaf-blind subject

• DOI: 10.1097/00001756-200402090-00015
• 发表时间: 2004-02-09
• 期刊: NEUROREPORT
• 影响因子: 1.7
• 作者: Osaki, Y;Doi, K;Kubo, T
• 通讯作者: Kubo, T