The Study for Improvement of Dental Titanium-based Materials with Sol-Gel Process

溶胶-凝胶法改进牙科钛基材料的研究

• 批准号: 07557272
• 负责人: WATARI Fumio
• 金额: $ 5.38万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557272/
• 关键词: Sol-gel method; Coating; Cell toxicity; Biocompatibility; チタン; 有機・無機複合体; 表面改質

In this study, we apply the sol-gel coating method with inorganic layr or organic-inorganic composite layr onto titanium alloys in order to improve the surface property.SEM observations and NSOM (Near-field Scanning Optical Microscope) observatons were carried in order to estimate the surface property of coated substrate. In these observation, oated layrs with sol-gel process were flat, no defect and translucent.The immobilization capacity of protains of coated specimens were estimated the enzymes such a alcohol dehydrogenase and dextranase. The coating with sol-gel method was effective to increase the capacity.The biocompatibility was estimated with in vitro test using the human osteoblast cells and hypodermic implantation into rats. The biocompatibility of nickel was improved with coating.

本研究采用溶胶-凝胶法在钛合金表面涂覆无机层或有机-无机复合层以改善钛合金的表面性能，并通过SEM和近场扫描光学显微镜（NSOM）观察涂层的表面性能。结果表明，溶胶-凝胶法制备的膜层平整、无缺陷、半透明，对乙醇脱氢酶和葡聚糖酶的固定化能力进行了评价。采用溶胶-凝胶法制备的涂层能有效地提高材料的容量，并通过体外实验和大鼠皮下植入实验评价了涂层材料的生物相容性。涂层改善了镍的生物相容性。

项目成果

UO,Motohiro: "Properties of Na_2O-CaO-SiO_2 glasses" J.J.Dent.Mater.Vol.14. 292-293 (1995)

UO，Motohiro：“Na_2O-CaO-SiO_2 玻璃的性能”J.J.Dent.Mater.Vol.14。

UO,Motohiro: "Coating of dental metals with sol-gel method" J.J.Dent.Mater.Vol.15. 340-341 (1996)

UO，Motohiro：“用溶胶-凝胶法涂覆牙科金属”J.J.Dent.Mater.Vol.15。

WATARI,Fumio: "Fabrication and Properties of Functionally Graded Dental Implant" Composite Part B. Vol.28. 5-11 (1997)

WATARI,Fumio：“功能分级牙种植体的制造和性能”复合材料 B 部分，第 28 卷。

宇尾基弘: "ゾル-ゲル法による歯科用金属のコーティング" 歯科材料・器械. 15巻・28号. 340-341 (1996)

Motohiro Uo：“通过溶胶-凝胶法涂覆牙科金属”《牙科材料和仪器》第 15 卷，第 28 期。340-341 (1996)