Development of novel membrane type artificial lung having controlled surface morphology

具有可控表面形态的新型膜式人工肺的开发

• 批准号: 07558131
• 负责人: NAGASAKI Yukio
• 金额: $ 3.46万
• 依托单位: Science University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07558131/
• 关键词: Artificial lung; Antithrombogenicity; poly (2-hydroxyethyl methacrylate); block copolymer; Silicon-containing polymers; polymer brush; Gas permselective membrane; 含ケイ素ポリマー; ガス透過; 血液適合性; 多相系表面; ぬれ; 膨潤度

Organosilicon-containing polystirene/poly (2-hydroxyethyl methacrylate)block copolymers were prepared by an anionic living polymerization technique. The obtained block copolymer showed unique thermodynamic properties. Especially, the block copolymer which possess only 10 mol% of poly (Si-stirene) segment showed very low glass transition temperature (Tg=10ﾟC) though both segments exhibit the fairly high Tgs (150 and 70ﾟC). The high flexibility of the copolymer chain caused extremely high blood compatibility. The obtained block copolymers also shows high gas exchange ability not only dry but also wet conditions due to the introduction of two organosilicon groups in each monomer unit. By construction of this film using this block copolymer on PP microporous membrane, the high performance membrane which possess both blood compatibility and high gas permeability was obtained.

采用阴离子活性聚合技术制备了含有机硅的聚苯乙烯/聚(甲基丙烯酸羟乙酯)嵌段共聚物。所得嵌段共聚物具有独特的热力学性质。尤其是嵌段含量仅为10ﾟ%的嵌段共聚物具有很低的玻璃化转变温度(Tg=10ﾟC)，而两个链段的玻璃化转变温度都很高(150和70 kgC)。共聚物链的高柔韧性导致了极高的血液相容性。由于在每个单体单元中引入了两个有机硅基团，所获得的嵌段共聚物不仅在干条件下表现出高的气体交换能力，而且在湿条件下也表现出高的气体交换能力。用这种嵌段共聚物在PP微孔膜上构建了一种既具有血液相容性又具有高透气性的高性能膜。

项目成果

長崎幸夫: "A creation of an intelligent surface-The design of a reactive surface with stimuli-sensitivity toward temperature and pH-" Plenum(in press),

Yukio Nagasaki：“智能表面的创造 - 对温度和 pH 值具有刺激敏感性的反应表面的设计 -” Plenum（正在印刷中），

S.Cammas, A.Harada, Y.Nagasaki, K.Kataoka: "Poly (ethylene oxide-co-beta-benzyl-L-aspartate) block copolymers : Influence of the poly (ethylene oxide) block on the conformationof the poly (beta-benzyl-L-aspartat) segment in organic solvents" Macromolecule

S.Cammas、A.Harada、Y.Nagasaki、K.Kataoka：“聚（环氧乙烷-共-β-苄基-L-天冬氨酸）嵌段共聚物：聚（环氧乙烷）嵌段对聚（环氧乙烷）构象的影响”

長崎幸夫: "Rubber elasticity transition of poly(silamine) induced by ionic interactions" Macromolecular Rapid Communications. 17(1). 51-58 (1995)

Yukio Nagasaki：“离子相互作用诱导的聚（硅胺）橡胶弹性转变”《高分子快速通讯》17（1）（1995）。

Y.Nagasaki: "A creation of an intelligent surface" Trends in Polymer Science. 4(2). 59-64 (1996)

Y.Nagasaki：“智能表面的创造”聚合物科学趋势。

Y.Nagasaki, Y.Hashimoto, M.Kato, T.Kimijima: "Gas permeation properties of organosilicon-containing polystirenes." Journal of Memrane Science. 110 (1). 91-97 (1996)

Y.Nagasaki、Y.Hashimoto、M.Kato、T.Kimijima：“含有机硅的聚苯乙烯的气体渗透性能。”