Development of novel membrane type artificial lung having controlled surface morphology

具有可控表面形态的新型膜式人工肺的开发

• 批准号: 07558131
• 负责人: NAGASAKI Yukio
• 金额: $ 3.46万
• 依托单位: Science University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07558131/
• 关键词: Artificial lung; Antithrombogenicity; poly (2-hydroxyethyl methacrylate); block copolymer; Silicon-containing polymers; polymer brush; Gas permselective membrane; 含ケイ素ポリマー; ガス透過; 血液適合性; 多相系表面; ぬれ; 膨潤度

Organosilicon-containing polystirene/poly (2-hydroxyethyl methacrylate)block copolymers were prepared by an anionic living polymerization technique. The obtained block copolymer showed unique thermodynamic properties. Especially, the block copolymer which possess only 10 mol% of poly (Si-stirene) segment showed very low glass transition temperature (Tg=10ﾟC) though both segments exhibit the fairly high Tgs (150 and 70ﾟC). The high flexibility of the copolymer chain caused extremely high blood compatibility. The obtained block copolymers also shows high gas exchange ability not only dry but also wet conditions due to the introduction of two organosilicon groups in each monomer unit. By construction of this film using this block copolymer on PP microporous membrane, the high performance membrane which possess both blood compatibility and high gas permeability was obtained.

采用阴离子活性聚合法制备了有机硅聚苯乙烯/聚甲基丙烯酸2-羟乙酯嵌段共聚物。所得嵌段共聚物表现出独特的热力学性质。其中，嵌段共聚物的玻璃化转变温度较低（Tg=10 C），但两段共聚物的玻璃化转变温度均较高（150 C和70 C）。共聚物链的高柔韧性使其具有极高的血液相容性。由于在每个单体单元中引入两个有机硅基团，所制得的嵌段共聚物无论在干燥条件下还是在潮湿条件下都表现出较高的气体交换能力。利用嵌段共聚物在PP微孔膜上构建该膜，获得了兼具血液相容性和高透气性的高性能膜。

项目成果

長崎幸夫: "A creation of an intelligent surface-The design of a reactive surface with stimuli-sensitivity toward temperature and pH-" Plenum(in press),

Yukio Nagasaki：“智能表面的创造 - 对温度和 pH 值具有刺激敏感性的反应表面的设计 -” Plenum（正在印刷中），

S.Cammas, A.Harada, Y.Nagasaki, K.Kataoka: "Poly (ethylene oxide-co-beta-benzyl-L-aspartate) block copolymers : Influence of the poly (ethylene oxide) block on the conformationof the poly (beta-benzyl-L-aspartat) segment in organic solvents" Macromolecule

S.Cammas、A.Harada、Y.Nagasaki、K.Kataoka：“聚（环氧乙烷-共-β-苄基-L-天冬氨酸）嵌段共聚物：聚（环氧乙烷）嵌段对聚（环氧乙烷）构象的影响”

長崎幸夫: "Rubber elasticity transition of poly(silamine) induced by ionic interactions" Macromolecular Rapid Communications. 17(1). 51-58 (1995)

Yukio Nagasaki：“离子相互作用诱导的聚（硅胺）橡胶弹性转变”《高分子快速通讯》17（1）（1995）。

Y.Nagasaki: "A creation of an intelligent surface" Trends in Polymer Science. 4(2). 59-64 (1996)

Y.Nagasaki：“智能表面的创造”聚合物科学趋势。

Y.Nagasaki, Y.Hashimoto, M.Kato, T.Kimijima: "Gas permeation properties of organosilicon-containing polystirenes." Journal of Memrane Science. 110 (1). 91-97 (1996)

Y.Nagasaki、Y.Hashimoto、M.Kato、T.Kimijima：“含有机硅的聚苯乙烯的气体渗透性能。”