Creation of High Performance Biocompatible Surface by Surface modification agent which Constructs High Density Tethered Chains

通过构建高密度系链的表面改性剂创建高性能生物相容性表面

基本信息

  • 批准号:
    10558139
  • 负责人:
  • 金额:
    $ 4.48万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).
  • 财政年份:
    1998
  • 资助国家:
    日本
  • 起止时间:
    1998 至 2000
  • 项目状态:
    已结题

项目摘要

We have synthesized seceral types of hydrophilic-hydrophobia block copolymers which forms supramolecular nanostructure in aqueous media due to the self-assembly of the block copolymers. For example, poly(ethylene glycol)/poly(lactide) block copolymer forms spherical core-shell type polymeric micelle in aqueous media, the size of which was 20-40 nm. The shell of the micelle was constructed by tethered PEG chains, whose density was very high in principle because of the thermodynamic balance.The objective of our study was to construct polymer micelle covered surface. If the surface was covered by spherical polymer micelles densely, the density of tethered chains should be much higher that conventional brushed chain surface.We prepared two types of polymer micelle. One of them is poly(2-hydroxyethyl methacrylate)-b-poly(alkylsilylstyrene) (HA) block copolymer micelle. By casting this polymer micelle on the substrate surface, the micelle adsorbed on the surface densely. Platelet adhesion to the modified surface was investigated. The adhesion on the HA-micelle modified surface was mush suppressed than that of not only native substrate but also poly(HEMA) surface. Entropy elastic effect of dense tethered chain may be the reason for this phenomena.Alternately, PEG/PLA block copolymers possessing aldehyde group at PEG chain end and methacryloyl group at PLA chain end was prepared. The block copolymer in aqueous media forms core shell type polymer micelle possessing aldehyde groups on the surface. The methacryloyl group in the core could be polymerized radically to form non dissociative micelle. To a primary-amino containing substrate surface, the aldehyde-micelle was modified covalently via reductive amination reaction. The obtained surface was very dence in polymer micelle and extremely high non-fouling character.These types of highly tethered chain surface was anticipating as new biocompatible surface modification agents.
我们合成了几种类型的亲水-疏水嵌段共聚物,由于嵌段共聚物的自组装,它们在水介质中形成了超分子纳米结构。例如,聚乙二醇/聚丙交酯嵌段共聚物在水介质中形成球形的核壳型聚合物胶束,其尺寸为20-40 nm。胶束的壳层是由链状聚乙二醇链构成的,由于热力学平衡,聚乙二醇链的密度原则上很高,我们研究的目的是构建聚合物胶束覆盖表面。如果表面被致密的球形聚合物胶束覆盖,系链链的密度应该比传统的刷链表面高得多。其中之一是聚(甲基丙烯酸2-羟乙酯)-b-聚烷基硅基苯乙烯(HA)嵌段共聚胶束。通过将这种聚合物胶束浇注在衬底表面,胶束密集地吸附在表面上。对改性后的表面进行了血小板粘附性研究。羟基磷灰石胶束修饰表面的粘附性比天然基质和聚(HEMA)表面的粘附性都受到明显的抑制。另外,合成了聚乙二醇链末端含醛基团、聚乳酸链端含甲基丙烯酰基的聚乙二醇/聚乳酸嵌段共聚物。所述嵌段共聚物在水介质中形成表面带有醛基团的核壳型聚合物胶束。核中的甲基丙烯酰基可以自由基聚合形成不解离的胶束。在含有伯氨基的底物表面,通过还原胺化反应对醛-胶束进行共价修饰。所得表面具有极高的聚合物胶束密度和极高的无污垢特性,这些类型的高度系链表面有望成为新型生物相容性表面改性剂。

项目成果

期刊论文数量(85)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kazunori Emoto, Yukio Nagasaki, Kazunori Kataoka: "A Core-Shell Structured Hydrogel Thin Layer on Surfaces by Lamination of a Poly(ethylene glycol)-b-poly(d, l-lactide Micelleand Polyallylamine"Langmuir. Vol.16(13). 5738-5742 (2000)
Kazunori Emoto、Yukio Nagasaki、Kazunori Kataoka:“通过层压聚(乙二醇)-b-聚(d,l-丙交酯胶束和聚烯丙胺,在表面形成核壳结构水凝胶薄层”Langmuir。Vol.16(13)
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    0
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長崎幸夫: "Polyion Complex Micelles with Reactive Aldehyde Groups on Surface from Plamid DNA and End-Functionalized Charged Block Copolymers"Macromolecules,Communication to the Editor. 32. 6892-6894 (1999)
Yukio Nagasaki:“来自质粒 DNA 和末端官能化带电嵌段共聚物表面具有反应性醛基的聚离子复合胶束”,《高分子》,致编辑 32. 6892-6894 (1999)。
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    0
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Hirakawa, Takashi Tokuda, Hidetoshi Aoki, Yukio Nagasaki, Masao Kato: "Dry-Developable Electron Beam Resist -Synthesis and Resist Characteristic Evaluation of Amino-ended Poly(a-Methylstyrene)-"Journal of Photopolymer Science and Technology. Vol.13(2). 21
Hirakawa、Takashi Tokuda、Hidetoshi Aoki、Yukio Nagasaki、Masao Kato:“干式显影电子束抗蚀剂-氨基末端聚(α-甲基苯乙烯)的合成和抗蚀剂特性评价-”光聚合物科学与技术杂志。
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    0
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長崎幸夫: "Selective Synthesis of Heterobifunctional Poly(ethylene glycol) Derivatives Containing Both Mercapto and Acetal Terminals"Bioconjugate Chemistry. 11/6. 947-950 (2000)
Yukio Nagasaki:“含有巯基和乙缩醛末端的异双功能聚乙二醇衍生物的选择性合成”生物共轭化学 11/6 (2000)。
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    0
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Hidenori Otsuka, Yukio Nagasaki, Kazunori Kataoka: "SDynamic Wettability Study on the Functionalized PEGylated Layer on a Polylactide Surface Constructed by the Coating of Aldehyde-ended Poly(ethylene glycol) (PEG)/polylactide (PLA) Block Copolymer"Scienc
Hidenori Otsuka、Yukio Nagasaki、Kazunori Kataoka:“由醛端聚乙二醇(PEG)/聚丙交酯(PLA)嵌段共聚物涂层构建的聚丙交酯表面官能化聚乙二醇化层的动态润湿性研究”科学
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NAGASAKI Yukio其他文献

NAGASAKI Yukio的其他文献

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{{ truncateString('NAGASAKI Yukio', 18)}}的其他基金

Design of injectable gel with NO releasing properties and its application
具有NO释放性能的注射凝胶的设计及其应用
  • 批准号:
    16K15628
  • 财政年份:
    2016
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Design of Novel Biomaterials which Scavenge Reactive Oxygen Species and Their Applications
清除活性氧的新型生物材料的设计及其应用
  • 批准号:
    25220203
  • 财政年份:
    2013
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (S)
A Challenge to Cerebral Diseases by Nanomedicine
纳米医学对脑疾病的挑战
  • 批准号:
    22659008
  • 财政年份:
    2010
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Design of Biomaterials Platform which responds to Oxidative Stress
响应氧化应激的生物材料平台设计
  • 批准号:
    21240050
  • 财政年份:
    2009
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Bionanosensing based on Bio-frontier Surface
基于生物前沿表面的生物纳米传感
  • 批准号:
    18200033
  • 财政年份:
    2006
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Design for Novel Stimuli-Sensitive Hydrogel, Polysilamine, and its Materials Design
新型刺激敏感水凝胶聚硅胺的设计及其材料设计
  • 批准号:
    14350502
  • 财政年份:
    2002
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of novel membrane type artificial lung having controlled surface morphology
具有可控表面形态的新型膜式人工肺的开发
  • 批准号:
    07558131
  • 财政年份:
    1995
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

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Postdoctoral Fellowship: MPS-Ascend: Cyclodextrin-Poly(ethylene glycol)-Based Dynamic Covalent Networks
博士后奖学金:MPS-Ascend:基于环糊精聚乙二醇的动态共价网络
  • 批准号:
    2316707
  • 财政年份:
    2023
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Fellowship Award
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
聚乙二醇免疫原性对植入物生物相容性的影响
  • 批准号:
    10504301
  • 财政年份:
    2022
  • 资助金额:
    $ 4.48万
  • 项目类别:
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
聚乙二醇免疫原性对植入物生物相容性的影响
  • 批准号:
    10697334
  • 财政年份:
    2022
  • 资助金额:
    $ 4.48万
  • 项目类别:
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
聚乙二醇免疫原性对植入物生物相容性的影响
  • 批准号:
    10809875
  • 财政年份:
    2022
  • 资助金额:
    $ 4.48万
  • 项目类别:
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
聚乙二醇免疫原性对植入物生物相容性的影响
  • 批准号:
    10798522
  • 财政年份:
    2022
  • 资助金额:
    $ 4.48万
  • 项目类别:
Targeting Oncogenic KRAS with Brush-Architectured Poly(ethylene glycol)-DNA Conjugates
使用刷状结构的聚(乙二醇)-DNA 缀合物靶向致癌 KRAS
  • 批准号:
    10430047
  • 财政年份:
    2020
  • 资助金额:
    $ 4.48万
  • 项目类别:
Targeting Oncogenic KRAS with Brush-Architectured Poly(ethylene glycol)-DNA Conjugates
使用刷状结构的聚(乙二醇)-DNA 缀合物靶向致癌 KRAS
  • 批准号:
    10653706
  • 财政年份:
    2020
  • 资助金额:
    $ 4.48万
  • 项目类别:
Targeting Oncogenic KRAS with Brush-Architectured Poly(ethylene glycol)-DNA Conjugates
使用刷状结构的聚(乙二醇)-DNA 缀合物靶向致癌 KRAS
  • 批准号:
    10210369
  • 财政年份:
    2020
  • 资助金额:
    $ 4.48万
  • 项目类别:
Targeting Oncogenic KRAS with Brush-Architectured Poly(ethylene glycol)-DNA Conjugates
使用刷状结构的聚(乙二醇)-DNA 缀合物靶向致癌 KRAS
  • 批准号:
    10035113
  • 财政年份:
    2020
  • 资助金额:
    $ 4.48万
  • 项目类别:
Rational design of poly(ethylene glycol) derivatives for reduction of antibody responses against poly(ethylene glycol)
合理设计聚乙二醇衍生物以减少针对聚乙二醇的抗体反应
  • 批准号:
    17K01393
  • 财政年份:
    2017
  • 资助金额:
    $ 4.48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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