Development of small caliber artificial graft with high degree of antithrombogenicity

本研究旨在开发具有控制合成抗凝剂释放的小口径合成移植物。这里开发的基质弹性体聚合物是由聚乙二醇作为软段衍生的分段聚氨酯。聚合物的亲水性和吸水性随着原料聚乙二醇分子量的增加而增加。这里使用的抗凝血剂是合成蛋白酶抑制剂MD-801和FUT-175。这些药物的合并是通过一步共铸过程，提供了优势比目前使用的复杂的过程，典型的肝素化。在体外和体内短期实验中证实了已证实的抗凝作用。本系统提出了一种易于实现的工艺新技术，特别是聚焦于小口径人工移植物的研制。

The present study aims to develop small caliber synthetic grafts with control release of synthetic anticoagulants. The matrix elastomeric polymer developed here is segmented polyurethanes derived from poly(ethylene glycol) as the soft segment. The hydrophilicity and water absorptivity of polymers increased with an increase in molecular weight of poly(ethylene glycol) used as a starting material. The anticoagulants used here were synthetic protease inhibitors named MD-801 and FUT-175. The incorporation of these drugs was via one-step co-casting process which provided advantage over the currently-used complicated processes typified as heparinization. The proven anticoagulation was demonstrated in in vitro and in vivo short-term experiments. The system developed here issues a new technology with easily-attainable process especially focusing to develop small caliber artificial graft.