Development of small caliber artificial graft with high degree of antithrombogenicity

具有高抗血栓形成能力的小口径人工移植物的研制

• 批准号: 60570612
• 负责人: IWATA Hiroo
• 金额: $ 1.15万
• 依托单位: National Cardiovascular Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570612/
• 关键词: Synthetic Graft; Polyurethane; ポリウレタン

The present study aims to develop small caliber synthetic grafts with control release of synthetic anticoagulants. The matrix elastomeric polymer developed here is segmented polyurethanes derived from poly(ethylene glycol) as the soft segment. The hydrophilicity and water absorptivity of polymers increased with an increase in molecular weight of poly(ethylene glycol) used as a starting material. The anticoagulants used here were synthetic protease inhibitors named MD-801 and FUT-175. The incorporation of these drugs was via one-step co-casting process which provided advantage over the currently-used complicated processes typified as heparinization. The proven anticoagulation was demonstrated in in vitro and in vivo short-term experiments. The system developed here issues a new technology with easily-attainable process especially focusing to develop small caliber artificial graft.

本研究旨在开发具有控制合成抗凝剂释放的小口径合成移植物。这里开发的基质弹性体聚合物是由聚乙二醇作为软段衍生的分段聚氨酯。聚合物的亲水性和吸水性随着原料聚乙二醇分子量的增加而增加。这里使用的抗凝血剂是合成蛋白酶抑制剂MD-801和FUT-175。这些药物的合并是通过一步共铸过程，提供了优势比目前使用的复杂的过程，典型的肝素化。在体外和体内短期实验中证实了已证实的抗凝作用。本系统提出了一种易于实现的工艺新技术，特别是聚焦于小口径人工移植物的研制。

项目成果

松田武久,他: 人工臓器. 14. 679-682 (1985)

Takehisa Matsuda 等人：人工器官。14. 679-682 (1985)

Takehisa Matsuda,et al.: Progress in Artificial Organs. 1029-1035 (1985)

Takehisa Matsuda 等人：人工器官的进展。

Takehisa Matsuda et al.: Trans.Amer.Soc.Int.Ogans.31. 151 (1985)

Takehisa Matsuda 等人：Trans.Amer.Soc.Int.Ogans.31。

野田裕幸,他: 人工臓器. 15. 282-285 (1986)

Hiroyuki Noda 等人：人工器官。15. 282-285 (1986)

Takehisa Matsuda et al.: "Novel Antithrombogenic Elastomers: Anticoagulant/Anticomplement Agent-Controlled Release Sytems" Trans. Amer. Soc. Int. Ogans. 31. 151 (1985)

Takehisa Matsuda 等人：“新型抗血栓形成弹性体：抗凝血/抗补体剂控制释放系统”Trans。