Development of small caliber artificial graft with high degree of antithrombogenicity

本研究的目的是开发具有合成抗凝剂控制释放的小口径合成移植物。这里开发的基质弹性体聚合物是由聚（乙二醇）作为软链段衍生的嵌段聚氨酯。聚合物的亲水性和吸水性随着用作起始材料的聚（乙二醇）的分子量的增加而增加。这里使用的抗凝剂是合成的蛋白酶抑制剂，命名为MD-801和FUT-175。这些药物的掺入是通过一步共铸工艺进行的，这比目前使用的以肝素化为代表的复杂工艺具有优势。在体外和体内短期实验中证明了已证实的抗凝作用。该系统的研制为小口径人工血管的开发提供了一种新的技术手段，其工艺简单，易于实现。

The present study aims to develop small caliber synthetic grafts with control release of synthetic anticoagulants. The matrix elastomeric polymer developed here is segmented polyurethanes derived from poly(ethylene glycol) as the soft segment. The hydrophilicity and water absorptivity of polymers increased with an increase in molecular weight of poly(ethylene glycol) used as a starting material. The anticoagulants used here were synthetic protease inhibitors named MD-801 and FUT-175. The incorporation of these drugs was via one-step co-casting process which provided advantage over the currently-used complicated processes typified as heparinization. The proven anticoagulation was demonstrated in in vitro and in vivo short-term experiments. The system developed here issues a new technology with easily-attainable process especially focusing to develop small caliber artificial graft.