DEVELOPMENT OF BIO-ACTIVE ARTIFICIAL BONE WITH THE SIMILLAR MECHANICAL PROPERTIES TO NATURAL BONE

具有与天然骨相似机械性能的生物活性人工骨的开发

• 批准号: 07558250
• 负责人: YOSHIMURA Masahiro
• 金额: $ 0.7万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07558250/
• 关键词: Hydroxyapatite; Calcium Phosphate; Apatite Composite; Bio-Compatibility; Fracture Toughness; Whisker; Artificial Bone; 破壊靱性; 水熱合成; 複合材料; 生体活性セラミックス; リン酸三カルシウム

The maximum problem for the artificial bone in orthopaedic surgery is the loosening between materials and natural bones. The purpose of the present research was the devolopment of the artificial bone without the loosening. Here we prepared hydroxyapatite (Ca_<10> (PO_4)_6 (OH)_2 : HA) bio-compatible composites with the selilar mechanical properties to natural bones, then the composites were characterized.(1) Phase transition in hydroxyapatiteThe monoclinic*hexagonal phase transition in the pure and stoichiometric HA was detected at the temperatures from 473K to 483K by X-ray diffraction and thermal analysis.(2) Preparation of hydroxyapatite whiskersHA whiskers were prepared hydrothermally at 200ﾟC from the solution containing calcium and phosphate ions and lactic acid as a chelating agent. The diameter and length of the whiskers were in the range of 1-10 mum and 30-50 mum. The whiskers were slight calcium deficient HA,but the reaction with calcite at 600ﾟC allows the control of Ca/P ra … More tio of the whiskers up to the stoichiometric value of 1.67.(3) Preparation of hydroxyapatite/hydroxyapatite (whiskers) compositesFor the first time in the histry of HA ocmposites, HA reinforced with HA whiskers was prepared by hot-pressing and HIP'ing. This composite had about 100% higher toughness than the non-reinforced pure HA.(4) Preparation of hydroxyapatite/bioactive glass laminated compositesLaminated HA/bioactive glass composits was prepared by hot-pressing. beta-NaCaPO_4 was found as a weak interface belong to high toughness ceramic composites of HA.(5) In vivo reaction for microstructure designed porous ceramics of hydroxyapatite and calcium phosphates Microstructure controlled HA.beta-TCP and HA/beta-TCP porous composites were implanted into the femoral condyles of adult rabbits. New bone formation and bio-degradation of those materials were analyzed quantitatively. The rate of bone formation an bio-degradation depended on the pore size and its distribution and the ratio of HA and beta-TCP. Less

人工骨在骨科手术中最大的问题是材料与天然骨之间的松动。本研究的目的是研制无松动的人工骨。本文制备了<10>具有与天然骨相似力学性能的羟基磷灰石（Ca_（PO_4）_6（OH）_2：HA）生物相容性复合材料，并对其进行了表征。(1)通过X射线衍射和热分析，在473 - 483 K的温度范围内，检测到纯HA和化学计量HA的单斜 * 六方相变。(2)羟基磷灰石晶须的制备以乳酸为螯合剂，在200 ℃水热条件下，以钙离子和磷酸根离子为原料，制备了羟基磷灰石晶须。晶须的直径和长度在1-10 μ m和30-50 μ m的范围内。晶须是轻微缺钙的HA，但在600 ℃下与方解石反应可以控制Ca/P比。 ...更多信息 晶须的TiO达到1.67的化学计量值。(3)羟基磷灰石/羟基磷灰石（晶须）复合材料的制备在HA复合材料史上首次采用热压-热等静压法制备了羟基磷灰石（HA）晶须增强HA。该复合材料具有比未增强的纯HA高约100%的韧性。(4)羟基磷灰石/生物活性玻璃层状复合材料的制备采用热压法制备了羟基磷灰石/生物活性玻璃层状复合材料。β-NaCaPO_4是高韧性HA陶瓷复合材料的弱界面。(5)羟基磷灰石和磷酸钙多孔陶瓷微结构设计的体内反应将微结构可控的HA、β-TCP和HA/β-TCP多孔复合材料植入成年兔股骨髁内。定量分析了材料的新骨形成和生物降解情况。骨形成和生物降解的速率取决于孔径及其分布以及HA和β-TCP的比例。少

项目成果

Hiroyuki Takahashi, etc.: "Synthesis of Stoichiometric (Ca/P=1. 67)Hydroxyapatite by a “Gel" Route from the Aqueous Solution of Citric and Phosphonoacetic Acids" Eur. J. Solid State and Inorg. Chem. , “Advanced Materials". 32. 829-835 (1995)

Hiroyuki Takahashi 等：“通过柠檬酸和膦乙酸水溶液的化学计量（Ca/P=1. 67）羟基磷灰石的合成”，Eur.J.Solid State and Inorg。 32.829-835（1995）

Wojciech Suchanek: "Bioactive Glass Laminated Composite-Fracture Behavior and Phase Compositiion" Bioceramics. 9. 177-180 (1996)

Wojciech Suchanek：“生物活性玻璃层压复合材料断裂行为和相组成”生物陶瓷。

Wojiciech Suchanek, etc.: "Biocompatible Whiskers with Controlled Morphology and Stoichiometry" J.Material Research. 10. 521-529 (1995)

Wojiciech Suchanek 等：“具有受控形态和化学计量的生物相容性晶须”J.材料研究。