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Serum melatonin rhythm in demented patients

痴呆患者血清褪黑素节律

基本信息

批准号：
07670081
负责人：
MORITA Yukitomo
金额：
$ 1.47万
依托单位：
Hamamatsu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670081/
关键词：
Melatonin aging dementia biological rhythm Alzheimer's disease sleep-activity rhythm radioimmunoassay light therapy 活動リズム

项目摘要

The daily rhythm of serum melatonin levels in patients with Alzheimer's disease was measured, in order to see whether patients with a history of the daily rhythm disorders show a pattern of melatonin rhythm different from that of normal subjects.Sixteen hospitalized patients with Alzheimer's disease were studied. The degrees of abnormality were moderate or severe. The mean age of these patients was 69 years. As control groups, 13 age-matched healthy people and 10 healthy young adults were measured. Blood samples were collected every 3h over a period of 24h. Serum melatonin was measured by radioimmunoassay procedure.Demented patients are inclined to suffer rhythm disorders. However, nearly 63% of the Alzheimer patients showed melatonin rhythm. The data suggest that the oscillators of these patients are functioning. Although the precise mechanism and pathogeneses of Alzheimer's disease are not identified at present, the rhythm disorder appears more often in the advanced stage of dementia. The sensitivity of the clock to the Zeitgebers decreases with aging. So, the sensitivity to the Zeitgebers, not only the disorder of the SCN and the related nervous pathways, must have an important role for the occurrence of the rhythm disorder in demented patients. Improving the Zeitgebers for the less-sensitive biological clock system may help to recover from the rhythm disorders.

通过测定阿尔茨海默病患者血清褪黑素的日节律，以了解有日节律紊乱史的患者是否表现出与正常人不同的褪黑素节律模式。异常程度为中、重度。这些患者的平均年龄为69岁。13名年龄匹配的健康人和10名健康青年作为对照组进行测量。在24小时内每隔3小时采集一次血样。血清褪黑素的测定采用放射免疫法。痴呆患者容易出现节律紊乱。然而，近63%的阿尔茨海默病患者表现出褪黑素节律。数据表明，这些患者的振荡器正在发挥作用。虽然阿尔茨海默病的确切发病机制和发病机制目前尚不清楚，但节律紊乱更多出现在痴呆的晚期。时钟对计时器的灵敏度随着年龄的增长而降低。因此，对时针的敏感性，不仅是SCN及其相关神经通路的紊乱，而且在痴呆患者节律紊乱的发生中起着重要作用。为不太敏感的生物钟系统改进计时器可能有助于从节律紊乱中恢复。