Analysis of cerebral functions stimulated by mastication on malocclusions by using PET

PET分析咬合不正咀嚼刺激脑功能

• 批准号: 07838003
• 负责人: MITANI Hideo
• 金额: $ 1.47万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07838003/
• 关键词: mastication; cerebral blood flow; positron emission tomography; malocclusions; skeletal pattern; Rolandic area; rCBF; normal occlusions; 不正咬合

The aim of this study was to obtain basic data regarding the relationships between cerebral functions stimulated by mastication and morphological features of occlusion.Six normal male volunteers, aged 21 to 32 years were included in this study. Occlusal and skeletal features of all subjects were examined by study models and cephalograms. Cerebral blood flow at rest and chewing gum base were measured with ^<15>O-labeled water by using Positron emission tomography. The regions of interest on cerebral blood flow image were drawn referring brain atlas. The change of blood flow at each regions were calculated.Changes of regional cerebral blood flow (rCBF) by chewing gum were widely varied. In normal occlusions with harmonious relationship of jaws, rCBF increasing were generally demonstrated on Rolandic area, insula and cerebellum. On the other hand, in malocclusions with any dental or skeletal problems, region and volume of increasing cerebral blood flow were different from that in normal occlusions, and rCBF were not almost increased by chewing gum on Rolandic area and insula in anyone with malocclusons.Results may be indicated that cerebral function stimulated by mastication are related with features of occlusion and skeletal pattern.

本研究的目的是获得咀嚼刺激的大脑功能与咬合形态学特征之间关系的基本数据。6名年龄在21至32岁之间的正常男性志愿者参与了这项研究。通过研究模型和脑电图检查所有受试者的咬合和骨骼特征。采用正电子发射断层扫描，用^<15> 0标记水测量静息时脑血流量和口香糖基底。参照脑图谱绘制脑血流图像感兴趣区域。计算各部位血流变化。咀嚼口香糖对局部脑血流量（rCBF）的影响差异很大。下颌关系和谐的正常咬合者，rCBF普遍在罗兰区、岛区和小脑区增加。另一方面，在任何牙齿或骨骼问题的错咬合中，脑血流增加的区域和体积与正常咬合不同，并且在任何错咬合患者中，咀嚼罗兰区和岛叶的口香糖几乎没有增加rCBF。结果提示咀嚼刺激的脑功能与咬合特征和骨骼形态有关。

项目成果

佐藤亨至、三谷英夫、マルコAメヒア、伊藤正敏: "ポジトロンCTによる咀嚼時脳血流動態と咬合との関連" 日本矯正歯科学会雑誌. 55. 300-310 (1996)

Toruji Sato、Hideo Mitani、Marco A. Mejia、Masatoshi Ito：“使用正电子 CT 观察咀嚼过程中脑血流动力学与咬合之间的关系”日本正畸学会杂志 55. 300-310 (1996)。

佐藤 亨至、三谷 英夫、マルコAメヒア、伊藤 正敏: "ポジトロンCTによる咀嚼時脳血流動態と咬合との関連" 日本矯正歯科学会雑誌. 55巻・4号. 300-310 (1996)

Toruji Sato、Hideo Mitani、Marco A. Mejia、Masatoshi Ito：“使用正电子 CT 观察咀嚼过程中脑血流动力学与咬合之间的关系”，日本正畸学会杂志，第 55 卷，第 4. 300-310 期（1996 年）。

Sato K., Mitani, H., Mejia M.A.and Ito M.: "Relationship between regional cerebral bllod flow during mastication and morphological features of occlusion" J.Jpn.Orthod.Soc.55. 300-310 (1996)

Sato K.、Mitani, H.、Mejia M.A. 和 Ito M.：“咀嚼过程中局部脑血流与咬合形态特征之间的关系”J.Jpn.Orthod.Soc.55。