Prospective study of rapid cycling affective disorder

快速循环情感障碍的前瞻性研究

• 批准号: 07671091
• 负责人: SAKAMOTO Kaoru
• 金额: $ 0.38万
• 依托单位: Tokyo Women's Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671091/
• 关键词: Rapid cycler; corisol; lithium; prognosis; 治療抵抗性

To our knowledge, there are only two prospective studies which have investigated the prognosis of rapid cycling affective disorder and their results vary quite considerably. Thus, the prognostic significance of rapid cycling remains an important question.We followed up 30 rapid cyclers who were treated aggressively with lithium, carbamazepine and sometimes in combination with other drugs. Of these 30, fourteen stopped cycling rapidly within the first year. On the other hand, the remaining sixteen comtinued to cycle rapidly. Their treatment responses differ accordingly to the duration of rapid cycling prior to intensive treatment.We also assessed hypothalamic-pituitary-adrenocortical axis function in patients with rapid cycling by measuring urinary free cortisol in the dexamethasone test. Our results show that rapid cycling patients have lower urinary free cortisol levels during hypomanic phases than during depressive phases. The present study confirmed the hypothesis that hypothalamic-pituitrary-adrenocortical axis function varies with the mood states of rapid cycling patients.

据我们所知，只有两项前瞻性研究调查了快速循环型情感障碍的预后，其结果差异很大。因此，快速循环的预后意义仍然是一个重要的question.We随访了30个快速循环谁是积极的治疗锂，卡马西平，有时与其他药物的组合。在这30人中，有14人在第一年内迅速停止骑自行车。另一方面，剩下的十六个继续快速循环。他们的治疗反应不同，相应的快速循环的持续时间之前，强化treatment.We还评估了下丘脑-垂体-肾上腺皮质轴功能的快速循环患者通过测量尿中游离皮质醇的地塞米松试验。我们的研究结果表明，快速循环患者有较低的尿游离皮质醇水平在轻躁狂阶段比在抑郁阶段。本研究证实了下丘脑-垂体-肾上腺皮质轴功能随快速自行车患者情绪状态而变化的假设。