An abnormal transcript of the heat shock protein 70 gene in patients with major depression

重度抑郁症患者热休克蛋白70基因的异常转录

• 批准号: 08671113
• 负责人: SAKAMOTO Kaoru
• 金额: $ 1.41万
• 依托单位: Tokyo Women's Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671113/
• 关键词: affective disorder; depression; biologival marker; heat shock protein; うつ病; 熱ショック蛋白質

The heat shock or stress genes are induced by a wide variety of stimuli including heat, oxidative stress, prolonged seizure, and certain toxins. It is suggested that heat shock proteins may play important roles in the process of mental stress. To our knowledge, there are no report which have investigated the heat shock protein expression in affective disorder.Thus, we investigated the hsp70 mRNA transcripton in human lymphocyte using RTPCR (reverse transcript polymerase chain reaction). Fourtenn of 15 patients with depression showed abnormal transcript of hsp70. In contrast, normal volunteers show no abnormal trascript. These result suggest Heat shock protein 70 may play an imortant role in the mechanism of depression.

热休克或应激基因由多种刺激诱导，包括热、氧化应激、长时间癫痫发作和某些毒素。提示热休克蛋白可能在心理应激过程中起重要作用。本研究采用逆转录聚合酶链反应（RTPCR）技术对人淋巴细胞热休克蛋白70（hsp70）mRNA的表达进行了研究。15例抑郁症患者中有4例hsp70转录异常。正常志愿者未见异常转录。提示热休克蛋白70可能在抑郁症发病机制中起重要作用。

项目成果

Shimizu Syoichi: "An Allel-specific abnormal transcript of the heat shock protein 70 gene in patients with major depression" Biochemical and Biophysical Research Communications. 219. 745-752 (1996)

Shimizu Syoichi：“重度抑郁症患者热休克蛋白 70 基因的等位基因特异性异常转录本”生物化学和生物物理研究通讯。

Tomitaka Shinichiro: "Regionally different effects of scopolamine on NMDA autageuist-incluced HSP 70" Brain Research. 763. 255-258 (1997)

Tomitaka Shinichiro：“东莨菪碱对包含 NMDA 自闭症的 HSP 70 的区域不同影响”脑研究。