STUDY OF ETIOLOGY AND TREATMENT ON DELIRIUM

谵妄的病因及治疗研究

基本信息

批准号：
07671094
负责人：
NAKAMURA Jun
金额：
$ 1.22万
依托单位：
KURUME UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671094/
关键词：
Delirium plasma free-MHPG plasma free-HVA Delirium Rating Scale せん妾せん妾の評価尺度 HVA MHPG 5-HIAA

项目摘要

The most frequent diagnosis of patients referred to the consultation liaison service (CLS) of Kurume University Hospital was delirium. The reason for this increase include in the number of delirious patients may have been due to the increased number of elderly patients who was hospitalized and increased need for hospitalization in emegency cases. We investigated the characteristics of patients with delirium who were identified and treated as part of the CLS to determine 60 patients. Delirium was diagosed in 34% in the CLS.Most patients with delirium were over 55 years of age and were postoperative patients ; findings inbcluded dehydration, disturbances of liver and renal, respiratory function, anemia, nutritional imbalnces, and setting of tube for IVH.The serum level of Na was significantly dectreased and urinary volume was increased during the delirious state compared with pre-delirious state. Undelying diseases of patients with delirium included in order of prevalence, malignancy, ce … More rebrovascular disease, digestive disorders, and other disorders.Until recently, neuroleptics such as haloperidol, oxypertine and tiapride were the principal drugs used in the treatment of derlirum in Japan. However, the use of neuroleptics sometimes caused oversedation, extrapyramidal symptoms, and other adverse side-effects. Therefore, we studied the effects of mianserin, (M) on delirium by assessing patients with Delirium Rating Scale as well as measurement of plasma concentration, free-MHPG and HVA concentraions. As a result, the plasma concentration of M reached a therapeutic level with 24 hr of the initiation of treatment. Based on the clinical results and on measurements of the plasma M concentrations, M can be considered effective in the treatment of delirium due to its rapid onset and few side-effects. M may offer an efficacy similar to that of haloperidol in the tretment of delirium while being safer. Although improvement in the delirious state and a decrease in the plasma free-MHPG concentration were observed after drug administration. The higher plasma free-MHPG concentration in the delirious state suggests the existence of a preparatory state whreby norepinephrine metabolism in involved in the appearance of abnormal behaviors associated with delirium. These data suggest that free-MHPG concentrations could potentially be used as a predictor of delirium. Less

最常见的诊断为参考库鲁姆大学医院咨询联络服务（CLS）的患者是Delirium。这种增加的原因包括狂热的患者数量可能是由于住院老年患者的数量增加，并且在emegency病例中增加了住院的需求。我们调查了del妄的患者的特征，这些患者被鉴定并被视为CLS的一部分，以确定60名患者。在CLS的34％中，del妄的大多数del妄患者的年龄超过55岁，患者为阳性。发现脱水的结果，肝和肾功能障碍，呼吸功能，贫血，营养失调以及IVH的管的设置。NA的血清水平显着降低，尿量在可爱状态期间的尿量增加，与预先疾病的疾病相比，多种疾病的疾病中的疾病相比，疾病中的疾病更具疾病，包括疾病的疾病，包括疾病的疾病。疾病和其他疾病。直到最近，诸如氟哌啶醇，氧化和tiapride之类的神经肽是日本derlirum治疗的主要药物。然而，神经疗法的使用有时会导致过度修饰，锥体外症状和其他不良副作用。因此，我们通过评估评估量表的评估患者以及血浆浓度，自由-MHPG和HVA浓度的评估患者研究了甲蛋白（M）对del妄的影响。结果，M的血浆浓度达到了治疗倡议24小时的治疗水平。根据临床结果和血浆浓度的测量，M可以被认为是由于其快速发作和副作用很少而有效治疗ir妄的治疗。在药物给药后观察到，M可能提供与氟哌啶醇相似的有效性，尽管脆弱状态的改善，但在脆弱状态的改善中也可以提供与血浆不含MHPG浓度的降低。在微妙的状态下，较高的血浆不含-MHPG浓度表明存在制剂状态呼吸比去甲肾上腺素的代谢，这与与del妄相关的异常行为的出现。这些数据表明，自由-MHPG浓度可能被用作del妄的预测指标。较少的