The variety of concepts in mood disorders and pharmaco-image-Molecular approach

情绪障碍和药物图像分子方法的各种概念

• 批准号: 21591494
• 负责人: NAKAMURA Jun
• 金额: $ 3.33万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591494/
• 关键词: うつ病; MRI; DTI; 脳由来栄養因子(BDNF); 血漿中MHPG; 血漿中HVA; NOx濃度; γ-アミノ酪酸(GABA); NOx; γ-アミノ酪酸; 脳由来栄養因子; NO_X濃度; GABA

1.We investigated the molecular-pharmacological and neuroimaging study in depressed patients, and we found the following results.2.Brain NAA level in PO regions with depressed group is significantly lower than that with healthy control.3.No difference is observed in Glx level between depressed group and healthy control.4.Serum MHPG is significantly higher in depressed group than that in healthy control.5.A trend for increase is found in depressed group compared with healthy group.

1.我们对抑郁症患者进行了分子药理学和神经影像学研究，得到以下结果。2.抑郁组PO区脑NAA水平显着低于健康对照。3.抑郁组与健康对照之间Glx水平无差异。4.抑郁组血清MHPG显着高于健康对照。5.抑郁组与健康组相比有升高趋势。

项目成果

Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers.

健康志愿者单次摄入舍曲林后，葡萄柚汁会改变血浆舍曲林水平。

• 发表时间: 2009
• 期刊: World J Biol Psychiatry 10
• 作者: Ueda N;et al.
• 通讯作者: et al.

Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia : Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches.

利培酮治疗反应和精神分裂症易感性的新候选基因的鉴定：药物基因组学、小鼠表达和遗传病例对照关联方法之间的综合分析。

• 发表时间: 2010
• 期刊: Biol.Psychiatry 67
• 作者: Ikeda M;et.al.
• 通讯作者: et.al.

Introducing the concept of modern depression in Japan; an international case vignette survey

• DOI: 10.1016/j.jad.2011.06.030
• 发表时间: 2011-12-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Kato, Takahiro A.;Shinfuku, Naotaka;Kanba, Shigenobu
• 通讯作者: Kanba, Shigenobu

Type A behavior pattern hyperthymic temperament : Possible association with bipolar IV disorder

A 型行为模式情绪高涨气质：可能与双相情感障碍有关

• 发表时间: 2011
• 期刊: Journal of Affective Disorders
• 影响因子: 6.6
• 作者: Yumei Wang・Terao;T・Hoaki;N・Goto;S・Tsuchiyama;K・Iwata;N・Yoshimura;R.・Nakamura;J.
• 通讯作者: J.

抗うつ薬の潜在的有害事象-賦活症状を中心に-

抗抑郁药的潜在不良事件 - 关注激活症状 -

• 发表时间: 2011
• 期刊: 最新精神医学
• 作者: Yoshimura;R.・Kishi T・Suzuki A・Nakano;W.・Sugita;A.・Hori;H.・Otani K・Iwata N・Nakamura;J.;中村純
• 通讯作者: 中村純