NK CELL ACTIVITY REGARDING DELIRIUM

与谵妄相关的 NK 细胞活性

• 批准号: 10670925
• 负责人: NAKAMURA Jun
• 金额: $ 0.64万
• 依托单位: University of Occupational and Environmental Health(UOEH)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670925/
• 关键词: delirium; 3-methoxy-4-hydroxyphenylglycol(MHPG); Natural killer(NK)cell activity; Prospective study

We measured and comparaed levels of plasma free 3-methoxy-4-hydroxy-phenyl-(ethylene)glycol(pMHPG), a major metabolite of noradrenaline, and natural killer(NK)cell activity in 26 patients prior to undergoing operations for cardiovascular diseases 11 of whom expressed delirium and 15 of which did not. In conclusion, we found that pMHPG levels before the operations were higher in patients with post-operative delirium than in the patients without, while NK cell activity showed no difference between the two groups. It is possible that hyperactivity of noradrenargic neurons is connected with the development of post-operative delirium. Further, we considered that measurements of pMHPG level before operation might be a useful tool to predict the occurrence of post-operative delirium.

我们测定和比较了26例心血管疾病手术前患者血浆去甲肾上腺素主要代谢产物游离3-methoxy-4-hydroxy-phenyl-(ethylene)glycol(pMHPG)，水平和自然杀伤(NK)细胞活性，其中11例患者表现为妄想，15例患者没有。综上所述，我们发现有术后精神障碍的患者术前pMHPG水平高于无术后精神障碍的患者，而NK细胞活性在两组间无差异。去甲肾上腺素能神经元的过度活动可能与术后妄想的发生有关。此外，我们认为，术前测量pMHPG水平可能是预测术后精神错乱发生的有用工具。

项目成果

Yamada,S.: "Saliva level of 3-methoxy-4-hydroxyphenylglycal in psychiatric outpatients with anxiety"International Clinical Psychopharmacology. 13. 213-217 (1998)

Yamada, S.：“精神科门诊焦虑症患者唾液中 3-甲氧基-4-羟基苯基糖的水平”国际临床精神药理学。

中村 純: "精神医学レビューNo.26 せん妄"ライフ・サイエンス. 8 (1988)

Jun Nakamura：《精神病学评论第 26 期谵妄》生命科学 8 (1988)。

Nakamura, J., Yoshimura, R., Okuno, T., Ueda, N., Hachida, M., Yasumoto, K., Egami, H., Maeda, H., Nishi, M., Aoyagi, S.: "Association of plasma free-3-methoxy-4-hydoroxy-phenyl(ethylene)glycol, natural killer cell activity, and delirium in post-operative

Nakamura, J.、Yoshimura, R.、Okuno, T.、Ueda, N.、Hachida, M.、Yasumoto, K.、Egami, H.、Maeda, H.、Nishi, M.、Aoyagi, S.：

Terao, T., Ohmori, O., Shinkai, T.: "A puzzling case of seizures and visual hallucinations during clomipramine treatment with a high dose but causing a low serum concentration"Acta Psychiatrica Scandinavia. 99(5). 388-392 (1999)

Terao, T.、Ohmori, O.、Shinkai, T.：“高剂量氯米帕明治疗期间出现癫痫发作和视幻觉的令人费解的病例，但导致血清浓度低”《斯堪的纳维亚精神病学学报》。

Yukimasa, T., Nakamura, J.: "Medication of insomnia and delirium in psycho-oncology.(in Japanese)"Japanese Journal of Clinical Psychopharmacology. 3(7). 635-641 (2000)

Yukimasa, T., Nakamura, J.：“心理肿瘤学中失眠和谵妄的治疗。（日语）”日本临床精神药理学杂志。