Study on the adaptation of the colon after bowel transplantation

肠移植后结肠适应的研究

• 批准号: 07671374
• 负责人: HASHIMOTO Tetsuo
• 金额: $ 1.41万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671374/
• 关键词: colon transplantation; adaptation; 小腸移植; 結腸移植; 絨毛

The present study examined the change of colon graft in LEW to LEW rats with orthotopic small bowel and colon transplantation. There is no villi in the colon mucosa in the rats receiving with total small bowel and colon transplant at the time of three month after transplantation. Thirty percent of the rats receiving with half of the small bowel and colon graft had villi formation in the colon mucosa. Functional study such as maltose and glucose absorption test showed no evidence of absorption ability of the colon graft. These data suggest that the villi formation after bowel transplantation may be relation with intestinal graft length and that the villi of the colon is immature.

本研究观察了LEW大鼠原位小肠和结肠移植后移植物的变化。全小肠和结肠移植组大鼠移植后3个月结肠黏膜内无绒毛。接受一半小肠和结肠移植物的大鼠中有30%的结肠粘膜中有绒毛形成。麦芽糖和葡萄糖吸收试验等功能研究表明，结肠移植物无吸收能力。提示肠移植后绒毛的形成可能与移植肠的长度有关，结肠绒毛发育不成熟。

项目成果

Yamamoto S,Hashimoto T., Yagi M et al.: "Genistein suppresses cellular injury following hepatic ischemia /reperfusion" Transplant Proc.28 (2). 1111-1115 (1996)

Yamamoto S、Hashimoto T.、Yagi M 等人：“金雀异黄素抑制肝缺血/再灌注后的细胞损伤”移植 Proc.28 (2)。

橋本 哲夫 他8名: "消化器外科領域における経管栄養の評価と今後の問題点" 消化と吸収. 18. 44-46 (1995)

Tetsuo Hashimoto 等 8 人：“胃肠外科领域管饲的评估和未来问​​题”《消化与吸收》18. 44-46 (1995)。

T. Hashimoto: "Treatment with FK506 prevents rejection of rat colon allografts." Transplantation. 57. 1548-1554 (1994)

T. Hashimoto：“FK506 治疗可防止大鼠同种异体结肠移植物的排斥反应。”

M. YAGI. T. HASHIMOTO et al.: "Four couse of Selenium Deficienay in Postoperative Long-Torm ENteral Nutrition" Natrition. 12. 40-43 (1996)

M.八木。

Yagi M., Tani T., Hashimoto T et al.: "Four cases of selenium deficiency in postoperative long-term enteral nutrition." Nutrition. 12 (1). 40-43 (1996)

Yagi M.，Tani T.，Hashimoto T等：“术后长期肠内营养缺硒四例”。