THE ESTIMATION OF A USEFUL LEVEL OF VITAMINE INTAKE AGAINST THE PREVENTION OF LUNG ADENOCARCINOMA

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The intake of vitmain E-supplemented diet which contained the vitamin about10-20 fold compared to control diet could significantly reduced the development of lung adenocarcinoma in mice. When this vitamin E-supplemented diet was provided, the increases of ornithine decarboxylase (ODC) activity, polyamine biosynthesis and proliferating cell nuclear antigen as markers of cell proliferation were almost suppressed. Immunohistochemical study using anti-ODC suppported viochemical results related to cell proliferation at the early stage of lung carcinogenesis. Vitamin E-dependent inhibition of prostaglandin E_2 production at an early stage of lung carcinogenesis contributed to a portion of the suppression of these events related to cell proliferation. Also, vitamin E reduced the frequency of K-ras mutation at the early stage of teh carcinogenesis which was a major event leading to the development of adenocarconoma. Overall, within the possible intake level in daily life, vitamin E could reduce the development of lung adenocarcinoma due to the regulation of cell proliferation during the carcinogenic process.