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The study of exercise treatment for cardiovascular diseases

运动治疗心血管疾病的研究

基本信息

批准号：
07680102
负责人：
IZAWA Tetsuya
金额：
$ 1.47万
依托单位：
TOKYO METROPOLITAN UNIVERSITY (1997)The University of Electro-Communications (1995-1996)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

The effects of chronic physical exercise (ET) on the sensitivity of thoracic aorta to norepinephrine and on adipocyte lipolysis were investigated in spontaneously hypertensive rats (SHR). After ET, the attenuated sensitivity of aorta to norepinephrine was observed in SHR rats as well as in normotensive rats. This attenuated sensitivity of aorta to norepinephrine after ET was still evident in endothelium-denuded aorta, but to a lesser extent than in endothelium-intact aorta. No significant difference in 60 mM KC1-induced tension between control and trained SHR rats was observed with or without endothelium after ET.The results suggest that levels of endothelium-dependent releasing factor may increase in response to norepinephrine after ET in SHR rats as well as in normotensive rats. In the separate experiments, adipocyte lipolysis was investigated in SHR rats after ET.Adipocyte lipolysis stimulated by various agonists, such as isoproterenol, dobutamine, salbutamol, BRL37344 and dibutyryl cyclic AMP, was blunted in non-trained SHR rats compared with normotensive rats. However, ET significantly increased adipocyte lipolysis stimulated by each agonist, although the maximal responses were less in SHR rats than in normotensive exercise-trained rats. Thus, ET significantly alter the responses of aorta to norepinephrine and those of adipocyte lipolysis to various agonists in SHR rats.

观察了慢性运动对自发性高血压大鼠（SHR）胸主动脉对去甲肾上腺素敏感性和脂肪细胞脂解的影响。ET后，SHR大鼠和正常血压大鼠主动脉对去甲肾上腺素的敏感性降低。内皮剥脱后主动脉对去甲肾上腺素的敏感性减弱，但程度低于内皮完整的主动脉。对照组和训练组SHR大鼠之间的60 mM KCl诱导的张力无显着差异，观察有或无内皮后ET。结果表明，内皮依赖性释放因子的水平可能会增加，在SHR大鼠以及血压正常的大鼠ET后去甲肾上腺素的反应。在单独的实验中，研究了ET后SHR大鼠脂肪细胞的脂解作用。与血压正常的大鼠相比，在非训练的SHR大鼠中，由各种激动剂，如异丙肾上腺素、多巴酚丁胺、沙丁胺醇、BRL 37344和二丁酰环腺苷酸刺激的脂肪细胞脂解作用减弱。然而，ET显着增加脂肪细胞脂解刺激的每一个激动剂，虽然最大的反应是在SHR大鼠低于血压正常的运动训练大鼠。因此，ET显著改变SHR大鼠主动脉对去甲肾上腺素的反应和脂肪细胞对各种激动剂的脂解反应。