Exercise prescription based on the circadian rhythm of adipocyte clock genes : The significance of chrono-exercise prescription

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The mRNA levels of both adipokines and metabolic genes were strongly correlated with those of clock genes. The mRNA expressions of adipokines and metabolic genes, which were obtained after the exercise performed at the peak of Bmal1 mRNA expression, differed from those obtained after the exercise performed at the bottom of Bmal1 mRNA expression. Melatonin affected the mRNA expressions of several genes regulating adipocyte metabolism and adipokines. The findings indicate that the circadian rhythm of adipokines genes and metabolic genes should be considered when the exercise is used for preventing and improving metabolic syndrome due to obesity.