Long-term potentiation of the corticorubral synapse produced by cerebro-cerebellar communication

脑-小脑通讯产生的皮质红质突触的长期增强

• 批准号: 07680894
• 负责人: ODA Yoichi
• 金额: $ 1.47万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680894/
• 关键词: red nucleus; long-term potentiation; corticorubral synapse; interpositorubral synapse; excitatory postsynaptic potential; cat; guinea pig; シナプス可塑性; 運動制御; 小脳-赤核シナプス; 連合学習

The red nucleus (RN) is located at the key position in the cerebrocerebellar communication system in mammals. The RN in cat receives direct projection from both the interpositus nucleus of cerebellum and sensorimotor and association cortices. The former makes synapses on the soma or proximal dendrites and the latter on the peripheral dendrites of the RN.It was reported that tetanization of the corticorubral fibers produced posttetanic potentiation, which lasted a few minutes, of the excitatory postsynaptic potentials (EPSPs) mediated by the corticorubral synapses. However, a long-term potentiation (LTP) has not been found at the synapses. In the present study, we demonstrated that conjunction of the tetanic stimulation of the corticorubral fibers and interpositorubral fibers induces an LTP of the corticorubral EPSPs. The LTP likely occurs specifically at the corticorubral synapses, since there was no change in either the interpositorubral EPSPs or input resistance of the RN cells. Thus, it is suggested that the conjunctive activities of the cerebral and cerebellar outputs induce a long-lasting change in the efficacy of corticorubral transmission, which may underlie motor learning of the voluntary movement mediated by the RN.

哺乳动物红核(RN)位于脑小脑通讯系统的关键部位。猫的RN既接受小脑间位核的直接投射，也接受感觉运动皮质和联合皮质的直接投射。前者在RN的胞体或近端树突上形成突触，后者在RN的外周树突上形成突触。据报道，强直刺激皮质-鲁滨脑纤维可产生持续数分钟的兴奋性突触后电位(EPSP)的增强。然而，在突触上还没有发现长时程增强(LTP)。在本研究中，我们证明了强直刺激皮质和腰椎间纤维可诱发皮质-腰部EPSPS的LTP。LTP可能特异性地发生在皮质-黑质突触，因为RN细胞的EPSP或输入阻力都没有改变。因此，我们认为，大脑和小脑输出的结合活动导致了皮质-鲁巴马区传递效应的长期变化，这可能是RN介导的自主运动的运动学习的基础。

项目成果

Kawasaki,Keisuke: "Long-lasting habituation of Mauthner cell-initiated escape response of goldfish" Neunosci. Res.Suppl.20. S244 (1996)

川崎圭介：“毛特纳细胞引发的金鱼逃逸反应的长期习惯”Neunosci。

Oda,Yoichi: "Inhibitory long-term potentiation underlying long-lasting habituation of goldfish escape response" Neurosci. Res.Suppl.20. S244 (1996)

Oda，Yoichi：“金鱼逃逸反应的长期习惯化背后的抑制性长期增强”神经科学。

Morita,M.: "Quantal analysis of long-term potentiation at inhibitory synapse of the goldfish Mauttrner cell" Jpn.J.Physiol. 45. S134 (1995)

Morita,M.：“金鱼 Mauttrner 细胞抑制性突触长期增强的定量分析”Jpn.J.Physiol。

Kawasaki,K.: "Inhibitory long-term potentiation underlying halituation of goldfish escape responce." Jpa.J.Physiol. (in press). (1995)

Kawasaki,K.：“金鱼逃避反应的厌食的抑制性长期增强。”

Oda, Y.: "Inhibitory long-term patenfiation underlying long-lasting habituation of goldfish escape response." Neurosic.Res.S20. S244 (1996)

Oda, Y.：“抑制性长期专利化是金鱼逃避反应长期习惯化的基础。”