Physiological and Behavioral Studies on a Link between LTP and Learning

LTP 与学习之间联系的生理和行为研究

• 批准号: 10680743
• 负责人: ODA Yoichi
• 金额: $ 1.98万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680743/
• 关键词: Long Term Potentiation; Synaptic Transmission; Memory learning; Mauthner Cell; Inhikitory Synapse; Eocape Behavior; Reticulospinal Newrons; Goldfish; 記憶; 学習; LTP; シナプス; 迷避運動

Long-term potentiation (LTP) of synaptic transmission is often considered a cellular model for learning and memory. This hypothesis depends upon the assumptions that physiological stimuli can induce LTP in vivo and that the LTP correlates with behavioral changes. However, modifiable synapses are generally embedded deep in complex circuits. In contrast, the goldfish Mauthner (M)-cell is easily accessible and initates a fast escape behavior in response to sudden stimuli. Here I report that repeated sound stimuli induce LTP of the feedforward inhibition which controls M-cell excitability. Furthermore this enhanced inhibitory transmission, reminiscent of LTP evoked by afferent tetanization is paralleled by a prolonged decrease in the probability of triggering the adaptive escape response due to M-cell firing.

突触传递的长时程增强（LTP）通常被认为是学习和记忆的细胞模型。这一假说依赖于生理刺激可以在体内诱导LTP以及LTP与行为变化相关的假设。然而，可修改的突触通常深埋在复杂的电路中。相比之下，金鱼的Mauthner（M）细胞很容易接近，并在突然刺激时引发快速逃避行为。在这里，我报告说，重复的声音刺激诱导LTP的前馈抑制，控制M细胞的兴奋性。此外，这种增强的抑制性传输，让人想起传入强直诱发的LTP，是由于M细胞放电引起的适应性逃避反应的概率延长下降而引起的。

项目成果

Oda,Y.: "Inhibitory long-term potentiation underlies anditory conditioning of goldfish escape behavion" Nature. 394. 182-185 (1998)

Oda，Y.：“抑制性长时程增强是金鱼逃逸行为的基础和条件调节”自然。

小田洋一: "LTP解析法"脳の科学. 21. 743-749 (1999)

小田洋一：《LTP分析方法》《脑科学》21. 743-749 (1999)。

Oda, Y.: "Functional organization of segmentally homologous reticulospinal neurons in teleost hindbrain"Soc. Neurosci. Abstr.. 25. 116 (1999)

Oda，Y.：“硬骨鱼后脑中节段同源网状脊髓神经元的功能组织”Soc。

小田洋一: "LTP 解析法"脳の科学. 21. 743-749 (1999)

小田洋一：《LTP分析方法》《脑科学》21. 743-749 (1999)。

Oda, Y.: "LTP"Clinical Neuroscience. 17. 107 (1999)

Oda, Y.：“LTP”临床神经科学。