Assessment-System of Early Senility in Down Syndrome

建立了唐氏综合征早期衰老评估系统。评估系统中有5个诊断工具。我们开发了（1）&lt;<Appearance-based Aging Scale>&gt;用于评估衰老的外观迹象，（2）&lt;<Multidimensional Checklist for the Regression>&gt;用于评估基于行为和态度的退化程度，（3）&lt;<Mental Status Examination>&gt;用于诊断精神/认知功能的退化程度，（4）&lt;<Dementia Scale>&gt;用于诊断痴呆，（5）&lt;<Motor Behavior Checklists>&gt;用于诊断运动功能的退化程度。此外，这些诊断工具的适用性得到了证实，与成年唐氏综合症。结果表明，老化的迹象和心理/身体能力的下降开始出现在40岁左右。被诊断为痴呆症的平均年龄为49.6岁。50岁及以上的受试者中有13人（18.8%）被诊断为痴呆症。成年唐氏综合症患者被分为健康老年型、阿尔茨海默病型和快速消退型。需要进一步修改任务，使其适合唐氏综合症早期衰老的评估。

Assessment system for early senility in Down syndrome was developed. There are 5 diagnostic tools in the assessment system. We developed (1) <<Appearance-based Aging Scale>> which is designed to assesses appearance signs of aging, (2) <<Multidimensional Checklist for the Regression>> which assesses the degree of regression based on behaviours and attitudes, (3) <<Mental Status Examination>> which is designed to diagnose the degree of the deterioration of mental/cognitive functions, (4) <<Dementia Scale>> which is designed to diagnose the dementia, (5) <<Motor Behavior Checklists>> which is designed to diagnose the degree of the deterioration of motor functions. Furthermore, the applicability of those diagnostic tools were confirmed with adults with Down syndrome.Results showed that both signs of aging and a decline in mental/physical abilities begin to appear at around 40 years of age. The mean age at which the diagnosis of dementia is given is 49.6. 13 (18.8%) of subjects aged 50 years and above were diagnosed as dementia.Adults with Down syndrome were categorized as the healthy senior type, s the Alzheimer's type, and the rapid regression type.A Further revision of the tasks would be needed to make it suitable for the assessment of early senility in Down syndrome.