Regulation of Gene Expression

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(1) ImmunologyUpon the agreement with CNRS,France in 1989, a joint research program in the field of immunology was first undertaken in 1994. In this fiscal year 1996 the research was focused on the following 4 points : a) Molecular basis for T cell differentiation, T cell tolerance, and pathogenesis of autoimmune disease ; b) Regulation of signal transducing cascade and gene expression during B cell development ; c) Molecular basis underlying signal transduction via antigen receptor complexes ; and d) Development and pathogenesis of immune system. Several remarkable achievements were established by using mouse transgenic techniques and they greatly contributed the establishment of new region of transgenics.(2) Embryologya) Functions of mammalian Polycomb group gene products were investigated. Genetic analysis using mel-18 and bmi-1 deficient mice revealed that these gene products were synergically required for the establishment of anterior-posterior axis. b) Enhancer elements required for the tissue specific expression of BETAB1-crystallin were identified by using cell culture and transgenic system.(3) Molecvlar RecognitionThe chemical compound, Thiosrepton, activated transcriptional activity of Thiosrepton-binding protein. Derivatives of Thiosrepton also possessed the same biological activity which was strongly correlated with the length of Deala-side chain.(4) BiosensorThe highly sensitive biosensor to detect the trace of an insecticide containing organic phosphorus was developed by using Acetylcholine esterace (AChE).