On the skin as an immunological organ

皮肤作为免疫器官

• 批准号: 08307009
• 负责人: TAMAKI Kunihiko
• 金额: $ 17.28万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08307009/
• 关键词: skin; immunological organ; T cells; Langerhans cells; keratinocytes; fibroblasts; hair; cytokine; 皮膚; ケロチノサイト; 繊維芽細胞; 共刺激分子; ハプテン; ヘルパーT細胞亜群; 樹状細胞; 情報伝達; 角層バリヤ-; 皮膚器官; αβTCR; γδTCR

In this research project, immunological aspect of the skin was studied from different viewpoints such as 1) T cells in the skin, 2) Langerhans cells (LC), 3) Keratinocytes (KC), 4) Fibroblasts (Fb) and 5)Hair. In this study the existence of T cells unique to the skin was proposed from clinical as well as basic mouse study. This would be very important in terms of the development of T cell mediated skin lesions such as cutaneous T cell lymphoma. LC was investigated as for their migration as well as maturation and/on activation by cytokines and haptens. The immunological regulation of KC was also studied with the relationship to the external stimuli such as bacteria, physical barrier destination. The participation of Fb and hair cycle in skin immunology was studied. Overall, this project revealed the importance of skin as an immunological organ and suggest more studies are necessary to reveal this.

在这个研究项目中，从不同的角度研究了皮肤的免疫学方面，例如1）皮肤中的T细胞，2）朗格汉斯细胞（LC），3）角质形成细胞（KC），4）成纤维细胞（Fb）和5）头发。在这项研究中，根据临床和基础小鼠研究，提出了皮肤特有的 T 细胞的存在。这对于 T 细胞介导的皮肤病变（例如皮肤 T 细胞淋巴瘤）的发展非常重要。研究了LC的迁移以及细胞因子和半抗原的成熟和/激活。还研究了 KC 的免疫调节与外部刺激（如细菌、物理屏障目的地）的关系。研究了Fb和毛发周期在皮肤免疫学中的参与。总体而言，该项目揭示了皮肤作为免疫器官的重要性，并表明需要更多的研究来揭示这一点。

项目成果

H.Yagi,M.Takigawa et al: "TCR V_β7^+Th_2 cells mediate UVB-induced suppresion of contact photosencitrity by relcasiy IL-10" J Immunol. 156. 1824-1831 (1996)

H. Yagi、M. Takikawa 等人：“TCR V_β7^+Th_2 细胞通过相关 IL-10 介导 UVB 诱导的接触光敏性抑制”J 免疫学杂志 156. 1824-1831 (1996)

Aiba S et.al.: "Phorbol 12-myuste 13 acetrle can transform monocyte-derived dendritic cells to different cell typessimilar to those found in dermatofilrona"J Cutan Pathrl. 25. 65-71 (1998)

Aiba S 等人：“佛波醇 12-myuste 13 acetrle 可以将单核细胞衍生的树突状细胞转化为与 dermatofilrona 中发现的细胞类似的不同细胞类型”J Cutan Pathrl。

Fusie M,Kato M,Tcovaki K: "Dysreyulated expression of transforming growth factor β and its type I and type II receptars in basal-cell carcinoma" Int J Cancer. 71. 505-509 (1997)

Fusie M、Kato M、Tcovaki K：“基底细胞癌中转化生长因子 β 及其 I 型和 II 型受体的表达异常”Int J Cancer 71. 505-509 (1997)。

Nishijima T,Tokura Y,Takigawa M: "Altered permeability and disordered cutaneous immunorejnlatary functids in mice with auk barried disruption" J Invest Dermatol. 109. 175-182 (1997)

Nishijima T、Tokura Y、Takikawa M：“auk 屏障破坏小鼠的渗透性改变和皮肤免疫功能紊乱”J Invest Dermatol。

Aiba S: "Maturation of Dendritic Cells Induced by Cytokines and Haptens"Tohoku J Exp Med. 184. 159-172 (1998)

Aiba S：“细胞因子和半抗原诱导的树突状细胞的成熟”Tohoku J Exp Med。