On the skin as an immunological organ

在本研究项目中，从不同的角度研究了皮肤的免疫学方面，例如1）皮肤中的T细胞，2）朗格汉斯细胞（LC），3）角质形成细胞（KC），4）成纤维细胞（Fb）和5）毛发。在这项研究中，从临床和基础小鼠研究中提出了皮肤特有的T细胞的存在。这对于T细胞介导的皮肤病变如皮肤T细胞淋巴瘤的发展非常重要。研究了LC的迁移以及成熟和/或细胞因子和半抗原的活化。同时研究了KC的免疫调节作用与细菌、物理屏障等外界刺激的关系。研究了纤维蛋白原（Fb）和毛发周期（hair cycle）在皮肤免疫中的作用。总的来说，该项目揭示了皮肤作为免疫器官的重要性，并建议需要更多的研究来揭示这一点。

In this research project, immunological aspect of the skin was studied from different viewpoints such as 1) T cells in the skin, 2) Langerhans cells (LC), 3) Keratinocytes (KC), 4) Fibroblasts (Fb) and 5)Hair. In this study the existence of T cells unique to the skin was proposed from clinical as well as basic mouse study. This would be very important in terms of the development of T cell mediated skin lesions such as cutaneous T cell lymphoma. LC was investigated as for their migration as well as maturation and/on activation by cytokines and haptens. The immunological regulation of KC was also studied with the relationship to the external stimuli such as bacteria, physical barrier destination. The participation of Fb and hair cycle in skin immunology was studied. Overall, this project revealed the importance of skin as an immunological organ and suggest more studies are necessary to reveal this.