Establishment of Langerhans cell-cell line and its spplication for treatment
Establishment of Langerhans cell-cell line and its spplication for treatment
批准号:
11470179
负责人:
TAMAKI Kunihiko
金额:
$9.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1999
资助国家:
日本
项目状态:
已结题
起止时间:
1999 至 2001
中文摘要
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英文摘要
We succeeded in getting purified (over 95%) mouse Langerhans cello (LC) and analyzed their characteristics. Although we have not yet succeeded in establishment of LC-all line , we could get the following results.(1) Using purified LC we analyzed the maturing mechanism during LC culture, (2) We also found the effect of GM-CSF, M-CSF, TNF-α, corticasteroid, cyclosporine A and FK506 on LC, (3) The effect of GM-CSF and TGF-β on IL-12 production by LC was studied. (4) CD23 expression by mouse LC and its modulation by cytokines was studied, and (4) Prion related protein expression by LC was found. The induction by TGF-βtreated LC is now under in imoestigation.
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Sugaya M et al.: "Expression of cellular prion-related protein by murine Langerhans cells and Reractinocytes"J Derm Sci. (in press).
Sugaya M 等人:“鼠郎格汉斯细胞和 Reactin 细胞表达细胞朊病毒相关蛋白”J Derm Sci。
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通讯作者:
Tada Y, et al.: "TGF-β upregulates IL-12 production by mause Langerhans Cell"Eur J Immunol. 31. 294-300 (2001)
Tada Y 等人:“TGF-β 上调小鼠 Langerhans 细胞的 IL-12 产生”Eur J 免疫学杂志 31. 294-300 (2001)
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Tada Y,Asahina A,Nakanva K,Tomwa M,Fujiwa H,Tamaki K.: "Granulocyte/macrophage colony stimulating factor inhibits IL-12 production of mouse Langerhans cells"J Immunol. 164. 5113-5119 (2000)
Tada Y、Asahina A、Nakanva K、Tomwa M、Fujiwa H、Tamaki K.:“粒细胞/巨噬细胞集落刺激因子抑制小鼠朗格汉斯细胞的 IL-12 产生”J 免疫学杂志。
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通讯作者:
Tada Y,Asahina A,Nakanva K,Migook,Tomwa M,Fujiwa H,Tamaki K.: "Transforming growth factor β up regulates CD40-engaged IL-12 production of mouse langerhans cells"Eur J Immunol.. 31. 294-300 (2001)
Tada Y、Asahina A、Nakanva K、Migook、Tomwa M、Fujiwa H、Tamaki K.:“转化生长因子 β 上调小鼠朗格汉斯细胞 CD40 参与的 IL-12 产生”Eur J Nutrition.. 31. 294-300 (2001)
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通讯作者:
Claudio Solgals,Nakamura K,Asahina A,Tamaki,K: "Functional CD40 liganol is expressed on epidemal Langerhans cells"Journal of Lzukocyte Biology. 66. 281-285 (1999)
Claudio Solgals、Nakamura K、Asahina A、Tamaki、K:“功能性 CD40 木脂醇在表皮朗格汉斯细胞上表达”Lzuk 细胞生物学杂志。
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共 20 条
Investigation of Langerhans cell stimulatory molecule and its application in skin disease therapy
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批准号:17209039
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.7万
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财政年份:2005
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负责人:TAMAKI Kunihiko
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依托单位:
The rote of chemokine and dendritic cells in skin diseases
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批准号:14207038
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$26.87万
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财政年份:2002
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负责人:TAMAKI Kunihiko
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依托单位:
On the skin as an immunological organ
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批准号:08307009
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$17.28万
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财政年份:1996
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负责人:TAMAKI Kunihiko
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依托单位:
Ontogeny of T cells in skin : extrathymic development
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批准号:07407024
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$21.31万
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财政年份:1995
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负责人:TAMAKI Kunihiko
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依托单位:
Modulation of signal transduction of human epidermal immunocompetent cells
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批准号:03454272
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1991
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负责人:TAMAKI Kunihiko
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依托单位:
The role of Japositive denditc cells in organ graht rejection
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批准号:61480227
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.65万
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财政年份:1986
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负责人:TAMAKI Kunihiko
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依托单位:
海外基金