The rote of chemokine and dendritic cells in skin diseases
The rote of chemokine and dendritic cells in skin diseases
批准号:
14207038
负责人:
TAMAKI Kunihiko
金额:
$26.87万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2004
中文摘要
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英文摘要
With regards to chemokines we extended our previous study TARC in atopic diseases and reported that TARC important in the pathophysiology of Bullous pemphigoid and mycosis fungoides. Since TARC is produced by keratinocytes(KC), we studied the regulatory mechanisums of chemokines from KC, using Hacla T cells, such as TARC,CTACK,MEC, Eotaxin3/.Furthermore we made transgenic mice over expressed TARC or CTACK in the epidermis.With regands to dendritic cells(DC), we studied purified Langerhans cells(LC) and splevic DC and reported various characteristics of LC,We are now trying to analyze in vivo data on these subjects using trans genie mice.
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High levels of TARC in blister fluid and sera of patients with bullous pemphigoid
大疱性类天疱疮患者水疱液和血清中 TARC 含量高
DOI:
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发表时间:
2003
期刊:
Br J Dermatol 148
影响因子:
--
作者:
[Kakinuma T, Tamaki K et al.]
通讯作者:
Tamaki K et al.
DOI:
10.1016/j.bbrc.2004.05.059
发表时间:
2004-07-02
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Fujita, H, Asahina, A, Tamaki, K]
通讯作者:
Tamaki, K
Mitsui H, Tamaki K et al.: "Differential expression and function of Toll-like receptors in Langerhans cells : comparison with splenic dendritic cells"J Invest Dermatol. 122. 95-102 (2004)
Mitsui H、Tamaki K 等人:“朗格汉斯细胞中 Toll 样受体的差异表达和功能:与脾树突状细胞的比较”J Invest Dermatol。
DOI:
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发表时间:
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影响因子:
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作者:
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通讯作者:
Kakinuma T, et al.: "Thymus and activation-regulated chemokine (TARC/CCL17) in mycosis fungoides : serum TARC levels reflect the disease activity of mycosis fungoides"J Am Acad Dermatol. 48. 23-30 (2003)
Kakinuma T 等人:“蕈样肉芽肿中的胸腺和活化调节趋化因子 (TARC/CCL17):血清 TARC 水平反映了蕈样肉芽肿的疾病活动性”J Am Acad Dermatol。
DOI:
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发表时间:
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作者:
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通讯作者:
Xiao T, Tamaki K et al.: "Both IL-4 and IL-13 inhibit the TNF-α and IFN-γ enhanced MDC production in a human keratinocyte cell line, HaCaT cells"J Dermatol Sci. 31. 111-117 (2003)
Xiao T、Tamaki K 等人:“IL-4 和 IL-13 均抑制人角质形成细胞系 HaCaT 细胞中 TNF-α 和 IFN-γ 增强的 MDC 产生”J Dermatol Sci. 31. 111-117 ( 2003)
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作者:
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共 8 条
Investigation of Langerhans cell stimulatory molecule and its application in skin disease therapy
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批准号:17209039
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.7万
-
财政年份:2005
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负责人:TAMAKI Kunihiko
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依托单位:
Establishment of Langerhans cell-cell line and its spplication for treatment
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批准号:11470179
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:1999
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负责人:TAMAKI Kunihiko
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依托单位:
On the skin as an immunological organ
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批准号:08307009
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$17.28万
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财政年份:1996
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负责人:TAMAKI Kunihiko
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依托单位:
Ontogeny of T cells in skin : extrathymic development
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批准号:07407024
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$21.31万
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财政年份:1995
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负责人:TAMAKI Kunihiko
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依托单位:
Modulation of signal transduction of human epidermal immunocompetent cells
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批准号:03454272
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1991
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负责人:TAMAKI Kunihiko
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依托单位:
The role of Japositive denditc cells in organ graht rejection
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批准号:61480227
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.65万
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财政年份:1986
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负责人:TAMAKI Kunihiko
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依托单位:
国内基金
海外基金
树突状细胞(Dendritic cells,DCs)介导的黏膜免疫对猪轮状病毒(PRV)感染的分子作用机制研究
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批准号:31272541
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项目类别:面上项目
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资助金额:82.0万元
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批准年份:2012
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负责人:王春凤
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依托单位: